Evaluation of antimicrobial activity of the hydrolate of Coridothymus capitatus (L.) Reichenb. fil. (Lamiaceae) alone and in combination with antimicrobial agents

Marino, Andreana; Nostro, Antonia; Mandras, Narcisa; Roana, Janira; Ginestra, Giovanna; Miceli, Natalizia; Taviano, Maria Fernanda; Gelmini, Fabrizio; Beretta, Giordano Domenico; Tullio, Viviana Cristina

doi:10.1186/s12906-020-2877-x

Cited by 26 publications

(21 citation statements)

References 50 publications

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“…In addition, in vitro inhibition of hyphal growth of B. cinerea by HYSs has also been assessed. It is well known that, unlike essential oils, hydrolates are water-miscible phases in which a complex mixture of oxygenated compounds, such as alcohols, ketones, ethers, aldehydes, and esters, and very low percentages of terpenes are dissolved [ 46 ]. Therefore, HYS-induced inhibition is due to low concentrations of active compounds having enhanced diffusion in the aqueous medium.…”

Section: Resultsmentioning

confidence: 99%

Assessing the Control of Postharvest Gray Mold Disease on Tomato Fruit Using Mixtures of Essential Oils and Their Respective Hydrolates

Brito

Hansen

Espinoza

et al. 2021

Plants

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Gray mold disease, which is caused by Botrytis cinerea Pers ex. Fr., results in serious economic losses to Lycopersicum esculentum (tomato) crop productivity. In this study, we explored the possibility that mixtures of essential oils (EOs) and their respective hydrolates (HYSs) could be used to control this disease. Thus, EOs and HYSs were obtained from Origanum vulgare, Thymus vulgaris, Citrus limon, and Citrus sinensis by hydrodistillation. In vitro antifungal activities were evaluated, and EC50 values of 15.9 and 19.8 µg/mL were obtained for EOs of thyme and oregano, respectively. These activities are due mainly to volatile compounds, thymol and carvacrol. Results from in vivo assays show that although most tomatoes were infested five days after inoculation, the damage was considerably reduced by the application of an EO/HYS mixture of thyme. The disease incidence indexes of B. cinerea tomato rot, percentage and severity, measured four days after inoculation, were reduced by 70% and 76%, respectively, as compared with the inoculum control. These results suggest that a combination of HYSs and EOs enhances antifungal activity, and that optimization of relative concentrations, volumes, and the nature of the compounds, could design a formulation able to control B. cinerea inoculum on tomato fruits.

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Section: Resultsmentioning

confidence: 99%

Assessing the Control of Postharvest Gray Mold Disease on Tomato Fruit Using Mixtures of Essential Oils and Their Respective Hydrolates

Brito

Hansen

Espinoza

et al. 2021

Plants

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“…Apart from this, it is established that hydrolate exhibited considerable antibacterial activities against the Gram-positive bacteria, while Gram negative bacteria were found to be resistant. This is most probably due to its outer membrane [43,52]. Furthermore, only L. intermedia hydrolate formulated in nanoemulsion exhibited activity against E. coli (MIC value was 0.75%) and B. cereus (MIC value 0.60%), whereas pure hydrolate was inactive on both bacteria strains [28].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…It can also be used as such for disinfection and cosmetic applications [5]. Furthermore, T. capitatus belongs to carvacrol chemotype [42,43], while T. vulgaris belongs to thymol chemotype [29], it is visible in the essential oil, as well as in the hydrolate composition. This confirmed the possibility of using thyme and oregano hydrolates as antimicrobial agents similarly to their essential oils [45].…”

Section: Introductionmentioning

confidence: 99%

Hydrolates: By-products of essential oil distillation: Chemical composition, biological activity and potential uses

Aćimović¹,

Tešević²,

Smiljanić³

et al. 2020

Adv Techol

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Hydrolates, also referred to as hydrosols, floral or distillate waters, as well as aromatic waters, are produced in the same isolation process with essential oils by steam distillation. A small amount of essential oil constituents is dissolved in hydrolates providing specific organoleptic properties and flavor, as well as biological activity which makes them useful as raw material in many industries. Their popularity is still on the rise, especially in aromatherapy. The objective in this review is to analyze the chemical compositions of hydrolates and their corresponding essential oils, as well as biological activity of hydrolates (antimicrobial, antioxidant and antiinflamatory) and potential uses, not only in food industry for flavoring, and preservation of fresh-cut fruits and vegetables, but also as functional (soft) drinks. However, hydrolates can be used in aromatherapy and cosmetics, as well as in organic agriculture and aquaculture.

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“…Coridothymus capitatus differentially interacted with itraconazole, depending on the targeted Candida spp. ; of clinical relevance is the synergistic effect of the EO with itraconazole against C. krusei, which is intrinsically resistant to fluconazole [ 74 ]. The combinatorial interaction of Mentha x piperita with commercial antifungal drugs (several azoles and amphotericin B) was investigated on different reference and clinical strains of Candida spp.…”

Section: Synergistic Interaction With Commercial Antifungal Drugsmentioning

confidence: 99%

Anti-Candida Activity of Essential Oils from Lamiaceae Plants from the Mediterranean Area and the Middle East

et al. 2020

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Extensive documentation is available on plant essential oils as a potential source of antimicrobials, including natural drugs against Candida spp. Yeasts of the genus Candida are responsible for various clinical manifestations, from mucocutaneous overgrowth to bloodstream infections, whose incidence and mortality rates are increasing because of the expanding population of immunocompromised patients. In the last decade, although C. albicans is still regarded as the most common species, epidemiological data reveal that the global distribution of Candida spp. has changed, and non-albicans species of Candida are being increasingly isolated worldwide. The present study aimed to review the anti-Candida activity of essential oils collected from 100 species of the Lamiaceae family growing in the Mediterranean area and the Middle East. An overview is given on the most promising essential oils and constituents inhibiting Candida spp. growth, with a particular focus for those natural products able to reduce the expression of virulence factors, such as yeast-hyphal transition and biofilm formation. Based on current knowledge on members of the Lamiaceae family, future recommendations to strengthen the value of these essential oils as antimicrobial agents include pathogen selection, with an extension towards the new emerging Candida spp. and toxicological screening, as it cannot be taken for granted that plant-derived products are void of potential toxic and/or carcinogenic properties.

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Evaluation of antimicrobial activity of the hydrolate of Coridothymus capitatus (L.) Reichenb. fil. (Lamiaceae) alone and in combination with antimicrobial agents

Cited by 26 publications

References 50 publications

Assessing the Control of Postharvest Gray Mold Disease on Tomato Fruit Using Mixtures of Essential Oils and Their Respective Hydrolates

Assessing the Control of Postharvest Gray Mold Disease on Tomato Fruit Using Mixtures of Essential Oils and Their Respective Hydrolates

Hydrolates: By-products of essential oil distillation: Chemical composition, biological activity and potential uses

Anti-Candida Activity of Essential Oils from Lamiaceae Plants from the Mediterranean Area and the Middle East

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