Evaluation of Antimicrobial Activity of Sida cordifolia Leaf Extract

Abstract

Objective: The objective of the study was to evaluate in-vitro efficacy of antibacterial, and antifungal activities of chloroform extract of leaf of Sida cordifolia L. against some human pathogenic bacterial and fungal strains. S. cordifolia (Malvaceae) is used as anti-rheumatic, analgesic, antipyretic, anti-asthmatic, nasal decongestant, antiviral, laxative, diuretic, aphrodisiac, hypoglycemic, hepatoprotective and in the treatment of Parkinson disease.
 Methodology: Chloroform extract of S.cordifolia was used for antimicrobial screening. Antibacterial activity was tested against pathogenic bacterial strains Eschericha coli and Staphylococcus aureus. Also antifungal activity was tested against one human pathogenic fungal strain i.e. Candida albicans. Antibacterial and antifungal activities of S. cordifolia extract was carried out by using disc diffusion method.
 Results: Chloroform extract of S. cordifolia showed the largest zone of inhibition (10mm) against S. aureus at 50µgm/mL and no zone of inhibition against E.coli at 50µgm/ml. Chloroform extract has shown more potent antibacterial activity against S.aureus. Chloroform extract was found to be more effective against human pathogenic fungus C. albicuns. The zone of inhibition of chloroform extract was 10mm.The phytochemical screening demonstrated the presence of different types of compounds like alkaloids, tannins and phenolic compounds which may contribute for the anti-microbial action of this plant. 
 Conclusions: The results concludes that chloroform extract of S. cordifolia leaf possess antimicrobial activity.

Antimycotic Activity of Some Medicinal Plants against Mucor circinelloides

“…The ethanol extract of N. indicum leaves showed antifungal activity against Aspergillus niger and Candida albicans with zone of inhibition of 10 mm and 13 mm, respectively [15]. The phytochemical screening and in vitro efficacy of antimicrobial activities of chloroform leaf extract of Sida cordifolia L. were studied against some human pathogenic bacterial and fungal strains [16]. The extracts of some Cassia, Detarium, and Ziziphus species showed antifungal activity against dermatophytes [17].…”

Anti-Candida Properties of Gossypium hirsutum L.: Enhancement of Fungal Growth, Biofilm Production and Antifungal Resistance

“…The authors have identified the presence of catechin, chlorogenic acid, rutin, and quercetin [29,30] compounds also identified in the extracts of G. hirsutum L., indicating a possible relation between the chemical content and biological activity of these species. Accordingly, a chloroformic extract obtained from Sida cordifolia (Malvaceae) showed antifungal activity against C. albicans, possibly due to the presence of flavonoids [31,32].…”

Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats

“…In its phytochemistry, there are compounds such as asparagine, tryptophan, alkaloids (ephedrine -sympathomimetics, hypaphoforine, vasicine, vasicinone, vasicinolbronchodilator), phytosterols, mucin, rutin and potassium nitrate [7,8] . Analgesic, anti-bacterial, antiinflammatory, hypoglycemic and hepatoprotective effects have also been reported in several studies [9,10] . In Brazil, it is used mainly as a natural anti-inflamatory [11] .…”