The in vitro antimycotic activity of the leaf extract of Catharanthus roseus, Lantana camara, Nerium indicum, Sida cordifolia, and Ziziphus mauritiana was studied against M. circinelloides. This fungal species causes mucormycosis (black fungus). Presently, mucormycosis is affecting COVID patients due to prolonged use of steroids. So, it is needed to require development of more effective and less toxic antimycotic agents for the treatment of mucormycosis. Plants and their extraction preparations have been used as medicine against infectious disease. In this research, aqueous, ethanol, and DMSO (dimethyl sulfoxide) leaf extracts were used for antimycotic activity. All leaf extracts of selected medicinal plants recorded significant activity against M. circinelloides. Ethanol leaf extract of C. roseus showed the highest antimycotic activity followed by N. indicum and L. camara. Z. mauritiana which showed moderate activity against M. circinelloides.

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Plant products have been used as medicines against fungal infectious diseases. In this research antimycotic activity of the leaf extracts of five medicinal plants (Nerium indicum, Catheranthus roseus, Lantana camera, Ziziphus mauritiana) were tested against three dermatophytes (Trichophyton mentagrophytes, Trichophyton rubrum and Microsporum. gypseum). Development of more effective and less toxic antimycotic agents is required for the treatment of dermatophytosis. The plant materials were extracted with methanol, ethanol and diethyl ether solvent to investigate their antimycotic activities in Vitro. Ethanol and methanol extracts of all selected medicinal plants were showed the positive activity against all tested dermatophytes. Diethyl ether extract was showed lowest activity against T. mentagrophytes and T. rubrum and showed moderate activity against M. gypseum. The three dermatophytes differed with regard to their susceptibility to plant extracts.

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Medicinal plants represent a rich source of antimycotic agents. Plant extract has been used traditionally to treat a number of infectious diseases. Medicinal plant Nerium indicum belongs to the family Apocynaceae. The leaf extracts of Nerium indicum exhibited significant antifungal activity against pathogenic fungi (A. niger, A. flavus and A. fumigatus).Aspergillus species were isolated from soil samples. The soil samples collected from Ajmer, Rajasthan (India). Antifungal activities of the different leaf extracts were compared with the zones of inhibition produced by the standard antibiotic (Gresiofulvin). The ethanol, aqueous and DMSO extracts of Nerium indicum showed high antifungal activity against Aspergillus species except ethanol extract show lowest activity against A. niger. These results support the leaf extract of Nerium indicum can be used to cure fungal infections in both plant and human beings.