Evaluation of Antioxidant, Analgesic and Antidiarrheal Activities of Methanolic Extract of Litsea monopetala (roxb.) Leaves

Ferdous, Md. Razowanul; Ashrafudoulla,; Hossain, Md. Shohel; Bellah, Sm Faysal

doi:10.4172/2167-065x.1000185

Cited by 6 publications

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“…In comparison, the methanolic extract of the leaves, at the doses of 100, 200 and 500 mg/kg b.w., produced 33.89%, 38.98% and 68.75% writhing inhibition, respectively, following acetic-acid stimulation [23,81]. By comparison, the bark of L. monopetela was more effective at alleviating peripheral nociception compared to the leaves, as the bark extract showed a higher inhibitory activity than the leaf extract at the same concentration of 100 mg/kg b.w.…”

Section: Litsea Liyuyingi Liou Homentioning

confidence: 94%

“…Litsea monopetala Roxb., synonymous to Litsea polyantha Juss., is a small to mediumsized evergreen tree that grows up to 18 m in height and 60 cm in diameter [81,163]. It is predominantly distributed in Nepal, Bangladesh and Northeast India, but can also be found in Yucatan, Southern Mexico, West Indies, the Bahamas, Bermuda, Florida, Philippine, Sri Lanka, Palestine, South and Central America, China, Burma, West Malaysia, Thailand and Myanmar [23,164]. The plant is characterized by its leaves that are elliptically oblong with rounded tips and pubescent on the underside, ovoid black fruits and flowers that are small and pale yellow, usually occurring in fives or sixes in rounded umbellate heads [81].…”

Section: Litsea Liyuyingi Liou Homentioning

confidence: 99%

“…Investigations on other compounds such as Conus venom peptides (MrIA, Contulakin G, Vc1.1, conantokin G), capsaicinoids, capsinoids and their synthetic analogues are also underway for development into new analgesics [19]. Despite these advances, progressive pharmacological investigations have continued to prospect other plant species as potential new sources of analgesic compounds including Litsea genus from the Lauraceae family [20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

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The Analgesic Potential of Litsea Species: A Systematic Review

Goh,

Samsul,

Mohaimin

et al. 2024

Molecules

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Various plant species from the Litsea genus have been claimed to be beneficial for pain relief. The PRISMA approach was adopted to identify studies that reported analgesic properties of plants from the Litsea genus. Out of 450 records returned, 19 primary studies revealed the analgesic potential of nine Litsea species including (1) Litsea cubeba, (2) Litsea elliptibacea, (3) Litsea japonica, (4) Litsea glutinosa, (5) Litsea glaucescens, (6) Litsea guatemalensis, (7) Litsea lancifolia, (8) Litsea liyuyingi and (9) Litsea monopetala. Six of the species, 1, 3, 4, 7, 8 and 9, demonstrated peripheral antinociceptive properties as they inhibited acetic-acid-induced writhing in animal models. Species 1, 3, 4, 8 and 9 further showed effects via the central analgesic route at the spinal level by increasing the latencies of heat stimulated-nocifensive responses in the tail flick assay. The hot plate assay also revealed the efficacies of 4 and 9 at the supraspinal level. Species 6 was reported to ameliorate hyperalgesia induced via partial sciatic nerve ligation (PSNL). The antinociceptive effects of 1 and 3 were attributed to the regulatory effects of their bioactive compounds on inflammatory mediators. As for 2 and 5, their analgesic effect may be a result of their activity with the 5-hydroxytryptamine 1A receptor (5-HT1AR) which disrupted the pain-stimulating actions of 5-HT. Antinociceptive activities were documented for various major compounds of the Litsea plants. Overall, the findings suggested Litsea species as good sources of antinociceptive compounds that can be further developed to complement or substitute prescription drugs for pain management.

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Section: Litsea Liyuyingi Liou Homentioning

confidence: 94%

Section: Litsea Liyuyingi Liou Homentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Analgesic Potential of Litsea Species: A Systematic Review

Goh,

Samsul,

Mohaimin

et al. 2024

Molecules

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“…Scavenging of DPPH free radical indicates the antioxidants potential of the extract which is effective in prevention, interception, and repair mechanism against injury in the biological system. The following formula was used to calculate the percentage of radical scavenging activity (Ferdous et al, 2018), as given in equation (1).(…”

Section: Antioxidant Activitymentioning

confidence: 99%

Study on Biological Activity of Litsea monopetala From Panchthar District of Nepal

Khanal

Bhatt

2020

J. Inst. Sci. Tech.

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The Panchthar, a hilly district of Eastern Nepal, has several medicinal plants which are used by indegenous people for the treatments of different diseases. In the present work, phytochemical and biological activities of hexane, ethyl acetate, acetone, and methanol extracts of Litsea monopetala leaves from the Pachthar district were analyzed. The phytochemical screening demonstrated the presence of major secondary metabolites like flavonoids, alkaloids, terpenoids, polyphenols, glycosides, and proteins. The antibacterial activity was estimated by the disc diffusion method against Bacillus substilus and Escherichia coli. The result showed that ethyl acetate extract exhibit the highest zone of inhibition (ZOI) value of 18 mm/disc. Acetone extract also showed significant antibacterial activity at the concentration of 100 mg/mL. Antioxidant activity from DPPH radical scavenging assay displayed the inhibitory concentration (IC50) values of dried methanol and acetone extracts were 30.74 μg/mL and 202.86 μg/mL, respectively. The methanol extract has the highest total phenolic content of 360.14 mg GAE/g extract and the highest total flavonoid content of 27.13 mg QE/g extract. The present study revealed that Litsea monopetala plant from the Panchthar district is a source of several bioactive substances and can be used in several drugs formulation.

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“…is used in cattle diarrhea, stomach ache, gastric ulcers, and bone fractures. 29 , 30 Lyonia ovalifolia (Wall.) Drude is traditionally used for scabies, wound healing, allergy, and parasitic infection, and as an insecticidal agent.…”

Section: Introductionmentioning

confidence: 99%

Screening of Antioxidant, Antibacterial, Anti-Adipogenic, and Anti-Inflammatory Activities of Five Selected Medicinal Plants of Nepal

Lamichhane¹,

Sharma²,

Sapkota³

et al. 2023

JEP

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Introduction Herbal products have been widely used for the treatment of diseases throughout the ages. In this research, we investigated antioxidant, antibacterial, anti-adipogenic, and anti-inflammatory activities of methanolic extracts of five ethnomedicinally important plants; namely, Alnus nepalensis , Dryopteris sparsa , Artocarpus lacucha , Litsea monopetala , and Lyonia ovalifolia . Methods We investigated the DPPH free radical scavenging potential, sensitivity of selected bacterial strains towards the extracts using a disc diffusion assay, anti-inflammatory activity in RAW-264.7 cells, and anti-adipogenic activity by the ORO assay in 3T3-L1 preadipocytes. Results and discussion The extract of A. nepalensis showed significant antioxidant activity (IC 50 =4.838 µ g/mL), followed by A. lacucha , L. monopetala , and L. ovalifolia , exhibiting comparable IC 50 values to that of ascorbic acid (IC 50 =5.063 µ g/mL). Alnus nepalensis also showed good antibacterial activity in disc diffusion methods, with remarkable zones of inhibition in A. baumannii (14.66 mm) and P. mirabilis (15.50 mm) bacterial species. In addition, A. nepalensis was found to increase adipogenesis in 3T3-L1 cells, evidenced by increased lipid deposition in differentiated 3T3-L1 cells. A similar pattern of increased adipogenesis was observed on treatment with L. ovalifolia extracts. On the other hand, A. lacucha effectively reduced lipid deposition in 3T3-L1 cells at 100 µ g/mL (75.18±6.42%) by inhibiting adipogenesis, showing its potential use in the management of obesity. Furthermore, A. lacucha 100 µg/mL (15.91±0.277 µ M) and L. monopetala 75 µ g/mL (12.52±0.05 µ M) and 100 µg/mL (11.77±0.33 µ M) significantly inhibited LPS-induced nitric oxide production in RAW 264.7 cells. Also, A. nepalensis and L. ovalifolia inhibited NO production significantly, endorsing their anti-inflammatory potential. Conclusion The findings from these in-vitro studies suggest that the selected five plants possess remarkable antioxidant, antibacterial, anti-adipogenic, and anti-inflammatory activities. This study opens the door to conduct further advanced in-vivo experiments to find possible le...

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Evaluation of Antioxidant, Analgesic and Antidiarrheal Activities of Methanolic Extract of Litsea monopetala (roxb.) Leaves

Cited by 6 publications

References 0 publications

The Analgesic Potential of Litsea Species: A Systematic Review

The Analgesic Potential of Litsea Species: A Systematic Review

Study on Biological Activity of Litsea monopetala From Panchthar District of Nepal

Screening of Antioxidant, Antibacterial, Anti-Adipogenic, and Anti-Inflammatory Activities of Five Selected Medicinal Plants of Nepal

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