Evaluation of antioxidant and anti-ulcerogenic effects of Eremurus persicus (Jaub &amp; Spach) Boiss leaf hydroalcoholic extract on ethanol-induced gastric ulcer in rats

Beiranvand, Mohammad; Bahramikia, Seifollah; Dezfoulian, Omid

doi:10.1007/s10787-021-00868-x

Cited by 25 publications

(11 citation statements)

References 64 publications

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“…Ranitidine is a first-line drug for gastric ulcers, which reduces gastric acid and gastric enzyme activity and decreases the degree of oxidative stress in gastric tissues after hydrochloric acid-ethanol ingestion. 39 The MDA content shows that WJSS significantly attenuates lipid peroxidation in gastric tissues and reduces oxidative stress in gastric tissues. The MDA content of the ranitidine group was the lowest, and the antioxidant effect was the best.…”

Section: Discussionmentioning

confidence: 95%

Effect of white jade snail secretion on antioxidant capacity and intestinal microbial diversity in mouse model of acute gastric ulcer

Cheng,

Wang,

et al. 2023

J Sci Food Agric

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BackgroundIn the present work, acute gastric ulcer models were constructed by administering hydrochloric acid/ethanol. The mice ingested WJSS through gastric infusion. Ulcer areas in gastric tissue were recorded, and malondialdehyde (MDA) and superoxide dismutase (SOD) were also measured. Notably, high‐throughput 16s rDNA analysis of intestinal flora and determination of amino acid composition in feces were performed to understand the effect of WJSS on model mice.ResultsCompared with the control group, the ulcer area in the WJSS low, middle and high‐concentration groups declined by 28.02%, 39.57% and 77.85%. The MDA content decreased by 24.71%, 49.58% and 64.25%, and the SOD relative enzyme activity fell by 28.19%, 43.37% and 9.60%. The amounts of amino acids in the low, middle and high‐concentration groups were slightly lower, and probiotic bacteria such as Bacteroidetes and Lactobacillales increased in different concentration WJSS groups. Adding WJSS contributes to the establishment of beneficial intestinal flora and the absorption of amino acids.ConclusionOur results showed that WJSS has a good effect on inhibiting the hydrochloric acid‐ethanolic gastric ulcer, suggesting that WJSS has excellent potential as a novel anti‐ulcer agent. Combined with ulcer area, MDA content, SOD content, gut probiotics and other indicators, a high concentration of WJSS had the best protective effect on acute gastric.This article is protected by copyright. All rights reserved.

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Section: Discussionmentioning

confidence: 95%

Effect of white jade snail secretion on antioxidant capacity and intestinal microbial diversity in mouse model of acute gastric ulcer

Cheng,

Wang,

et al. 2023

J Sci Food Agric

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“…Our findings were in line with those of previous studies indicating that 80% ethanol induces gastric ulcers by increasing ROS levels. The generation of high levels of ROS in gastric tissue plays a vital role in the formation of lipid peroxides, such as MDA, and is accompanied by antioxidative enzyme activity impairment in cells [ 42 , 43 ]. The results of the present study demonstrated that rats exposed to ethanol showed severe gastric lesions, increased free radical levels, and decreased levels of both antioxidative enzymes and non-enzymatic antioxidants.…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective and Antioxidative Effects of the Traditional Thai Polyherbal Formula Phy-Blica-D against Ethanol-Induced Gastric Ulcers in Rats

et al. 2021

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Phy-Blica-D is a traditional Thai polyherbal formula that has reduced oxidative stress in non-communicable diseases. However, evidence supporting the gastroprotective effects of Phy-Blica-D has not been previously reported. Therefore, this study aimed to evaluate the gastroprotective effects of Phy-Blica-D against gastric ulcers in rats and investigate the potential underlying mechanism. To estimate the possible mechanisms of action, we examined the levels of oxidative stress markers, such as reactive oxygen species (ROS) and malondialdehyde (MDA), as well as antioxidant enzymes, including catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH). According to our results, rats treated with only 80% ethanol (vehicle group) exhibited significant increases in their ulcer area and ulcer index (UI). Moreover, the levels of ROS and MDA markedly increased in the vehicle group compared with the normal control group. Daily oral administration of Phy-Blica-D (500 and 1000 mg/kg) for 7 days not only significantly decreased the ulcer area and UI, but also remarkably decreased the ROS and MDA levels in gastric tissue. Gastric ulcers induced by ethanol had significantly decreased antioxidant enzyme activities (CAT and SOD) and non-enzymatic antioxidant (GSH), whereas pretreatment with Phy-Blica-D significantly improved the activities of CAT, SOD, and GSH. Moreover, after exposure to ethanol, the rats exhibited a significantly increased level of inducible nitric oxide synthase (iNOS), which was reduced after treatment with Phy-Blica-D. These findings suggest that Phy-Blica-D potentially exerts its gastroprotective effects by suppressing oxidative stress and stimulating antioxidant enzymes, which is one of the causes of destruction of cell membranes, and it is involved in the pathogenesis of acute gastric ulcers induced by ethanol.

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“…To eliminate oxidative stress and prevent gastric ulcer formation, Malaysian medicinal plants rich in antioxidant compounds are widely used for gastroprotection and gastric ulcer healing as a traditional remedy. The high antioxidant activity of medicinal plants is mainly due to the presence of phenolic compounds [45,46] and other plant-derived compounds [47].…”

Section: Antioxidant Mechanismmentioning

confidence: 99%

Potential Effect of Medicinal Plants on the Prevention of Gastric Ulcer: Mechanism of Actions

Qader¹,

Chua

Fournier

et al. 2022

J. Pharm. Nutr. Sci.

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Medicinal plants have been widely studied to identify plant-based anti-gastric ulcer medicines. The mechanism of gastroprotective action is important to discover the potential lead compounds for drug development. All relevant articles between 2011 and 2021 focusing on Malaysian plants were collected and analyzed to understand the underlying pathways. Keywords include peptic ulcer, gastric ulcer, NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), Helicobacterpylori, medicinal plant, gastroprotection, antiulcer, acid secretion, cytoprotective, and digestion processes were applied in the search engines. Twenty-two of the plants had been reported based on the collected data. The review concludes that Malaysian plants could protect the gastric wall against necrotizing agents like ethanol and NSAIDs. This is mainly due to four critical defensive mechanisms: cytoprotective barriers, regulation of heat-shock protein 70 (HSP70) and pro-apoptotic protein (BAX), gastric acid secretion, and antioxidant capability. The mechanisms have been illustrated in the schematic diagrams for better understanding.

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Evaluation of antioxidant and anti-ulcerogenic effects of Eremurus persicus (Jaub & Spach) Boiss leaf hydroalcoholic extract on ethanol-induced gastric ulcer in rats

Cited by 25 publications

References 64 publications

Effect of white jade snail secretion on antioxidant capacity and intestinal microbial diversity in mouse model of acute gastric ulcer

Effect of white jade snail secretion on antioxidant capacity and intestinal microbial diversity in mouse model of acute gastric ulcer

Gastroprotective and Antioxidative Effects of the Traditional Thai Polyherbal Formula Phy-Blica-D against Ethanol-Induced Gastric Ulcers in Rats

Potential Effect of Medicinal Plants on the Prevention of Gastric Ulcer: Mechanism of Actions

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