Evaluation of Antioxidant and Antiulcer Potential of Cucumis sativum L. 
 Seed Extract in Rats

Gill, N.S.; Garg, M.L.; Bansal, R. K.; Sood, Shailja; Muthuraman, Arunachalam; Bali, M.; Sharma, PD

doi:10.3923/ajcn.2009.131.138

Cited by 54 publications

(27 citation statements)

References 14 publications

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“…Nonetheless, among the fruit extract, methanol (IC 50 598 µg/mL) represented highest DPPH· scavenging activity (Figure 1). The results obtained are in accordance with Gill et al [11] who reported that methanol extract of cucumber seeds showed significant radical scavenging activity (76.2%) at a concentration of 700µg/mL. Nasrin et al [13] observed significantly high radical scavenging activity (IC 50 13.06 µg/mL) for methanol extract of cucumber.…”

Section: Total Flavonoids Contentsupporting

confidence: 81%

“…C. sativus contain bioactive molecules such as phenols, flavonoids, terpenoids, tannin, saponin and glycosides which are responsible for various biological properties. The different parts such as seeds, leaves, fruits showed various pharmacological activities such as antioxidant, antiulcer, antimicrobial, anti-inflammatory [11,12,13], antidibetic, hypolipidemic [14], analgesic, cytotoxic and antifungal [15,16]. While mining the data from the resources, work has been focused on C. sativus (Cucumber) but no information is available on its wild progenitor Cucumis sativus f. hardwickii.…”

Section: -112mentioning

confidence: 99%

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Proximate composition, antioxidant activities and phenolic composition of <em>Cucumis sativus</em> forma hardwickii (Royle) W. J. de Wilde & Duyfjes

Attar¹,

Ghane²

2017

ijpm

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A b s t r a c tIn the present investigation, nutritional, anti sativus of addition, appreciable amount of Vitamin C and E were also observed. Considerable antinutritional factors in leaf a methods. In sequential solvent extraction, methanol found to be the best in extraction of antioxidants which was supported with the highest antioxidant activities. Among all it was noted that leaves extracted with methanol had higher amount of phenols and flavonoids than fruit. In addition, the potent radical scavengers mainly phenolics were detected using RP HPLC where tannic acid, gallic acid and hydroxybenzoic acid were also fruit. Superior antioxidant potential may be due to presence of other bioactive compounds present in fruit. Additional research on bioactive properties of this plant is needed to explore this neglected wild cucumber for nutraceutica Keywords chromatography Introduction Nutrition is the basic need to ensure better health and development. Nutrient deficiency and/or over sufficiency cause various disorders such as diabetes, obesity, cardiovascular diseases, cancer [1]. The various epidemiological studies have been proved that balanced diet along with fruit and vegetables may reduce risk of many chronic diseases [2]. In order to meet optimum nutritional requirement, there is urgent need to explore wild plant species as a novel source of food. Across the world various geo communities uses series of wild plant species to meet their daily requirement of dietary energy. These wild resources are the best source of nutrient and bioactive compounds. In addition, it is also an important source of income to hunters, gatherers and rural people [3]. Exploring these wild plants as a source of functional foods assist us to alleviate malnutrition, hunger and illness within society. Such wild plants with high nutritional and low antinutritional potential are the prerequisite while deciding the functional foods. In the present investigation, nutritional, anti-nutritional and antioxidant potential of sativus forma hardwickii was evaluated for the first time. The results revealed that leaf and fruit of Cucumis sativus f. hardwickii were rich source of ash, carbohydrate, fat, fibre and proteins. In addition, appreciable amount of Vitamin C and E were also observed. Considerable antinutritional factors in leaf and fruit were noted which can be reduced by different processing methods. In sequential solvent extraction, methanol found to be the best in extraction of antioxidants which was supported with the highest antioxidant activities. Among all t was noted that leaves extracted with methanol had higher amount of phenols and flavonoids than fruit. In addition, the potent radical scavengers mainly phenolics were detected using RP HPLC where tannic acid, gallic acid and hydroxybenzoic acid were also fruit. Superior antioxidant potential may be due to presence of other bioactive compounds present in fruit. Additional research on bioactive properties of this plant is needed to explore this neglected wild cucumber for nutraceutical...

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Section: Total Flavonoids Contentsupporting

confidence: 81%

Section: -112mentioning

confidence: 99%

Proximate composition, antioxidant activities and phenolic composition of <em>Cucumis sativus</em> forma hardwickii (Royle) W. J. de Wilde & Duyfjes

Attar¹,

Ghane²

2017

ijpm

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“…The study reported that all the three peel extracts nearly reversed most of the changes induced by alloxan suggesting their possible role in ameliorating diabetes mellitus and related changes in serum lipids. Gill et al 16 reported that the cucumber seed possess significant antiulcer potential owing to its antioxidant activity.…”

Section: Dixit and Karmentioning

confidence: 99%

In Vitro Antioxidant and Antimicrobial Properties of Cucumis Sativus L. Peel Extracts

John¹,

Priyadarshini²,

Monica³

et al. 2018

Int. Res. J. Pharm.

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The present study evaluated the phytochemicals, antioxidant and antimicrobial potential; and thin layer chromatographic studies of Cucumis sativus L. peel extracts. The total flavonoid content was assessed using Aluminium Chloride reagent method. The antioxidant potential was evaluated using in vitro assays viz DPPH radical scavenging assay, FRAP and Phosphomolybdenum assay. The antimicrobial activity was determined against Shigella flexneri, E coli, Staphylococcus aureus and Klebsiella pneumonia using Agar Well Diffusion method. Qualitative phytochemical analysis confirmed the presence of alkaloids, saponins, diterpenes, steroids and flavonoids. Total Flavonoid content in the Cucumis sativus L. peel was 3.50 µg/mg QE. Cucumis sativus L. peel showed highest radical scavenging activity of 71% at the concentration of 600 µg/mL. In determination of antioxidant activity via FRAP and Phosphomolybdenum assay cucumber peel extract showed highest absorbance of 0.80 and 0.94 respectively at the concentration of 300 µg/mL. The peel extracts inhibited the growth of all the tested pathogens by forming inhibition zones ranging from 11-21 mm. Thin layer chromatographic studies of the cucumber peel extracts constituted different coloured phytochemical compounds with different Rf values. This study highlights the pharmacological properties of Cucumis sativus L. peel.

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“…The main part of ZES is fruits of Berberis vulgaris L. (Berberidaceae) known as Zereshk in Iran, and the name of ZES has essentially been derived from the Persian name of this plant. Some studies on ingredients of ZES have shown radical scavenging potential, 5 and hepatoprotective effects of these plants. 6 Moreover, some major compounds like emodin, 7 alkaloids, 8 phenolics, anthocyanins, 9 tannins, terpens 10 have been reported in these plants too.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Characterization, Standardization and In vitro Determination of Radical Scavenging Activity of Zereshk-e- Saghir, A Traditional Preparation, and Its Ingredients

Sarhadynejad¹,

Pardakhty²,

Mandegary³

et al. 2017

JYP

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Objective: Quality control and standardization of traditional preparations ensure their safe, pure and efficient prescription. Zereshk-e-Saghir (ZES), a folk remedy, has been recommended as a hepatoprotective agent in Traditional Persian Medicine (TPM). This study aimed at the evaluation of the physicochemical and phytochemical characterization, standardization, and in vitro antioxidant capacity determination of ZES and its ingredients. Method: Some qualitative and quantitative controls were performed like ash value, moisture content, extractable matter, phytochemical screening, TLC fingerprint and microbial contamination. Total phenolic and emodin contents of ZES were measured by spectrophotometric method to standardize this preparation. Finally in vitro radical scavenging activity of ZES and its ingredients were determined using 2, 2-Diphenyl-1-picrylhydrazyl (DPPH) assay. Result: Regarding the physicochemical evaluation, the amount of each parameter (ash value, moisture content, and extractable value) was determined as documented characteristics for ZES components. Phytochemical screening of ZES ingredients indicated the presence of tannins in all the samples and the presence of alkaloids, steroids and terpenoids in a majority of the samples. Meanwhile, ZES exhibited no pathogenic contamination. The emodin and total phenolic contents (TPC) of ZES were reported 457.0 µg emodin/100g and 381.5 mg gallic acid equivalents (GAE)/100 g of ZES, respectively. Also TPC ranged from 3607.4 to 27.9 mg GAE/ 100 g of ZES ingredients. Meanwhile, the results demonstrated that ZES could scavenge DPPH radicals (IC 50 value: 266.4 µg/ ml). Conclusion: The obtained results on quality control and standardization of ZES could be proposed as a monograph having standard characteristics.

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Evaluation of Antioxidant and Antiulcer Potential of Cucumis sativum L. Seed Extract in Rats

Cited by 54 publications

References 14 publications

Proximate composition, antioxidant activities and phenolic composition of <em>Cucumis sativus</em> forma hardwickii (Royle) W. J. de Wilde & Duyfjes

Proximate composition, antioxidant activities and phenolic composition of <em>Cucumis sativus</em> forma hardwickii (Royle) W. J. de Wilde & Duyfjes

In Vitro Antioxidant and Antimicrobial Properties of Cucumis Sativus L. Peel Extracts

Physicochemical Characterization, Standardization and In vitro Determination of Radical Scavenging Activity of Zereshk-e- Saghir, A Traditional Preparation, and Its Ingredients

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Evaluation of Antioxidant and Antiulcer Potential of Cucumis sativum L. Seed Extract in Rats

Cited by 54 publications

References 14 publications

Proximate composition, antioxidant activities and phenolic composition of <em>Cucumis sativus</em> forma hardwickii (Royle) W. J. de Wilde &amp; Duyfjes

Proximate composition, antioxidant activities and phenolic composition of <em>Cucumis sativus</em> forma hardwickii (Royle) W. J. de Wilde &amp; Duyfjes

In Vitro Antioxidant and Antimicrobial Properties of Cucumis Sativus L. Peel Extracts

Physicochemical Characterization, Standardization and In vitro Determination of Radical Scavenging Activity of Zereshk-e- Saghir, A Traditional Preparation, and Its Ingredients

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Product

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Proximate composition, antioxidant activities and phenolic composition of <em>Cucumis sativus</em> forma hardwickii (Royle) W. J. de Wilde & Duyfjes

Proximate composition, antioxidant activities and phenolic composition of <em>Cucumis sativus</em> forma hardwickii (Royle) W. J. de Wilde & Duyfjes