Evaluation of Antioxidant, Anti-inflammatory and Analgesic Activities of Leaves of Saba senegalensis (A.DC) Pichon (Apocynaceae)

Belemlilga, Mohamed Bonewendé; Traoré, Tata Kady; Boly, Gilchrist A. L.; Ouédraogo, Noufou; Traore, Aristide; Lompo, Marius; Ouédraogo, Sylvin; Guissou, Innocent Pierre

doi:10.9734/ejmp/2019/v27i330116

Cited by 10 publications

(6 citation statements)

References 32 publications

(46 reference statements)

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“…The CuO-NPs studied in the CFA-induced monoarthritis resulted in substantially decreased paw volume in comparison to the control . Phenolic and terpenoid chemicals are known to possess anti-inflammatory properties, and this may explain the anti-inflammatory effects in these experiences . Based on findings obtained via the leukocyte migration test, it seems that the mechanism of action of NPs involves altering the migration of leukocytes into the tissues and target organs .…”

Section: Resultsmentioning

confidence: 99%

“…61 Phenolic and terpenoid chemicals are known to possess anti-inflammatory properties, and this may explain the anti-inflammatory effects in these experiences. 62 Based on findings obtained via the leukocyte migration test, it seems that the mechanism of action of NPs involves altering the migration of leukocytes into the tissues and target organs. 63 Adjuvant arthritis is utilized widely in etiology research as well as to evaluate novel natural treatments.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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In Vivo Analgesic, Anti-Inflammatory, and Anti-Diabetic Screening of Bacopa monnieri-Synthesized Copper Oxide Nanoparticles

et al. 2022

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In this work, an ecofriendly approach for biogenic production of copper oxide nanoparticles (CuO-NPs) was proposed by utilizing the Bacopa monnieri leaf extract as a reducing and stabilizing agent. The synthesis of CuO-NPs was instantly confirmed by a shift in the color of the copper solution from blue to dark gray. The use of UV−visible spectroscopy revealed a strong narrow peak at 535 nm, confirming the existence of monoclinic-shaped nanoparticles. The average size of CuO-NPs was 34.4 nm, according to scanning electron microscopy and transmission electron microscopy studies. The pristine crystalline nature of CuO-NPs was confirmed by X-ray diffraction. The monoclinic form of CuO-NPs with a crystallite size of 22 nm was determined by the sharp narrow peaks corresponding to 273, 541, 698, 684, and 366 Bragg's planes at different 2θ values. The presence of different reducing metabolites on the surface of CuO was shown by Fourier transform infrared analysis. The biological efficacy of CuO-NPs was tested against Helicobacter felis, Helicobacter suis, Helicobacter salomonis. and Helicobacter bizzozeronii. H. suis was the most susceptible strain with an inhibition zone of 15.84 ± 0.89 mm at 5 mg/mL of NPs, while the most tolerant strain was H. bizzozeronii with a 13.11 ± 0.83 mm of inhibition zone. In in vivo analgesic activity, CuO-NPs showed superior efficiency compared to controls. The maximum latency time observed was 7.14 ± 0.12 s at a dose level of 400 mg/kg after 90 min, followed by 5.21 ± 0.29 s at 400 mg/kg after 60 min, demonstrating 65 and 61% of analgesia, respectively. Diclofenac sodium was used as a standard with a latency time of 8.6 ± 0.23 s. The results observed in the rat paw edema assays showed a significant inhibitory activity of the plant-mediated CuO-NPs. The percentage inhibition of edema was 74% after 48 h for the group treated with CuO-NPs compared to the control group treated with diclofenac (100 mg/kg) with 24% edema inhibition. The solution of CuO-NPs produced 82% inhibition of edema after 21 days when compared with that of the standard drug diclofenac (73%). CuO-NPs vividly lowered glucose levels in STZ-induced diabetic mice, according to our findings. Blood glucose levels were reduced by about 33.66 and 32.19% in CuO-NP and (CuO-NP + insulin) groups of mice, respectively. From the abovementioned calculations, we can easily conclude that B. monnieri-synthesized CuO-NPs will be a potential antibacterial, anti-diabetic, and anti-inflammatory agent on in vivo and in vitro basis.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

In Vivo Analgesic, Anti-Inflammatory, and Anti-Diabetic Screening of Bacopa monnieri-Synthesized Copper Oxide Nanoparticles

et al. 2022

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“…In this study, the hydroethanolic extract (IC 50 = 35.61 µg/ml) S. senegalensis showed good antioxidant activity and the aqueous extract (IC 50 = 69.57 µg/ml) had moderate activity. Belemlilga et al (2019) obtained a contrary result in their study, but the DCM fraction of the hydroethanolic extract presented the highest reducing power with a concentration of 88.88 mmol TE/g. Studies have shown that the polyphenolic compounds in the extracts may be good electron and hydrogen atom donors, and thus able to stop radical chain reactions by converting free radicals into more stable products (Amarowicz et al, 2004;Shettar et al, 2015).…”

Section: Ferric Reducing Antioxidant Power (Frap)mentioning

confidence: 83%

In vitro inhibition of cyclooxygenases, anti-denaturation and antioxidant activities of Malian medicinal plants

Mahamadou¹,

Karim²,

Abdoulaye³

et al. 2023

Afr. J. Pharm. Pharmacol.

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Cyclooxygenase 2 (COX-2) is involved in the production of prostaglandins that sustain the inflammatory process. Inflammatory cells release a number of reactive species. Furthermore, reactive oxygen species can initiate intracellular signaling cascades and enhance the expression of proinflammatory genes. The objective was to study the cyclooxygenase and protein denaturation inhibition and antioxidant activity of ten extracts from five plants. Cyclooxygenases inhibitory activity of the extracts was measured using the Cayman Kit method and the protein denaturation inhibitory activity using the bovine serum albumin. Ferric reducing antioxidant power and hydrogen peroxide scavenging activity were used to evaluate the antioxidant capacity of aqueous and hydroethanolic extracts. COX-2 inhibition was more important with the hydroethanolic extract of X. americana (IC 50 = 11.13 ± 1.24 µg/ml) and T. macroptera (IC 50 = 12.79 ± 0.56 µg/ml). COX-1 was strongly inhibited with the hydroethanolic extract of S. senegalensis. The hydroethanolic extracts of C. tinctorium and X. americana showed the strongest inhibitory activities of protein denaturation with 86.61 ± 1.22% and 84.5 ± 0.56% respectively. The greatest effects on iron reduction were observed with the hydroethanolic extracts of X. americana (R 2 = 0.996; IC 50 = 29 µg/ml) and T. macropteria (R 2 = 0.990; IC 50 = 35.46 µg/ml). The hydrogen peroxide scavenging activity of the extracts varied from 39.31 ± 3.6 to 77.37 ± 2.16 µg/ml. The present study concluded to an important antioxidant activity, protein denaturation and COX-2 inhibitory activities of the hydroethanolic extracts of X. americana, T. macroptera and C. tinctorium. Further studies are needed to confirm the anti-inflammatory effect of these extracts in vivo.

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“…Previously, similar results showed, strong antiradical activity with T. macroptera, X. americana, C. tinctorium and S. senegalensis were reported. [20][21][22][23]…”

Section: Abts Radical Scavenging Activitymentioning

confidence: 99%

study of antiradical activity, phospholipase A and 15-lipoxygenase inhibitory activity of eight malian medicinal plants used by traditional healers to treat inflammatory diseases

N.H²,

Karim³

et al. 2022

IJPP

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Pro-inflammatory enzymes play a key role in inflammatory processes and are potential targets of anti-inflammatory drugs. In this study, the objective was to evaluate the antiradical activity of the extracts and their ability to inhibit phospholipase A and 15-lipoxygenase activity. The hydroethanolic extract of revealed the strongest reducing power with an IC of 7.29 ± 0.61 µg/mL. The three most active extracts on PLA were hydroethanolic extracts of (IC of 21.43 ± 0.66 μg/mL), (IC of 23.72 ± 0.71 µg/mL), (IC of 24.49 ± 0.39 µg/mL). The best inhibitory activity on 15-lipoxigenase was obtained with aqueous and hydroethanolic extracts of with IC of 18.35 ± 1.26; 18.47 ± 1.12 µg/mL respectively. The present study showed that extracts of leaves of and roots of have antioxidant activity and effectively inhibit sPLA, and 15-LOX pro-inflammatory enzymes

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Evaluation of Antioxidant, Anti-inflammatory and Analgesic Activities of Leaves of Saba senegalensis (A.DC) Pichon (Apocynaceae)

Cited by 10 publications

References 32 publications

In Vivo Analgesic, Anti-Inflammatory, and Anti-Diabetic Screening of Bacopa monnieri-Synthesized Copper Oxide Nanoparticles

In Vivo Analgesic, Anti-Inflammatory, and Anti-Diabetic Screening of Bacopa monnieri-Synthesized Copper Oxide Nanoparticles

In vitro inhibition of cyclooxygenases, anti-denaturation and antioxidant activities of Malian medicinal plants

study of antiradical activity, phospholipase A and 15-lipoxygenase inhibitory activity of eight malian medicinal plants used by traditional healers to treat inflammatory diseases

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