The current study reports advanced, ecofriendly and biosynthesized silver NPs for diverse biomedical and environmental applications using Flammulina velutipes as biosource. In the study, a simple aqueous extract of F. velutipes was utilized to reduce the AgNO3 into stable elemental silver (Ag0) at a nanometric scale. The NPs had average size of 21.4 nm, spherical morphology, and were highly stable and pure. The characterized nanoparticles were exploited for a broad range of biomedical applications including bacteriocidal, fungicidal, leishmanicidal, in vitro antialzheimer’s, antioxidant, anti-diabetic and biocompatibility studies. Our findings showed that F. velutipes mediated AgNPs exhibited high activity against MDR bacterial strains and spore forming fungal strains. All the tested urinary tract infection bacterial isolates, were resistant to non-coated antibiotics but by applying 1% of the synthesized AgNPs, the bactericidal potential of the tested antibiotics enhanced manifolds. The NPs also exhibited dose-dependent cytotoxic potential against Leishmania tropica with significant LC50 of 248 μg ml−1 for promastigote and 251 μg ml−1 for amastigote forms of the parasite. Furthermore, promising antialzheimer and antidiabetic activities were observed as significant inhibition of α-amylase, α-glucosidase, acetylcholinesterase (AChE) and butrylcholineterase (BChE) were noted. Moreover, remarkable biocompatible nature of the particles was found against human red blood cells. The biosynthesized AgNPs as photocatalyst, also resulted in 98.2% degradation of indigo carmine dye within 140 min. Owing to ecofriendly synthesis, biosafe nature and excellent physicochemical properties F. velutipes AgNPs can be exploited as novel candidates for multifaceted biomedical and environmental applications.

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Highlights Drawbacks of chemical fertilizers have attracted the attention of farmers toward biofertilizers. Nitrogen fixer Azotobacter SR-4 and phosphorus solubilizer Asphergillus Niger were produced and observed to be efficient biofertilzers. A significant increase in yield parameters were observed when these biofertilizers were evaluated on Bottle gourd and okra. In conclusion, biofertilizers or microbial inoculants could be used as an alternate source, which are both cost-effective as well as eco-friendly.

We develop a new mathematical model by including the resistive class together with quarantine class and use it to investigate the transmission dynamics of the novel corona virus disease (COVID-19). Our developed model consists of four compartments, namely the susceptible class, the healthy (resistive) class, the infected class, and the quarantine class, . We derive basic properties like, boundedness and positivity, of our proposed model in a biologically feasible region. To discuss the local as well as the global behaviour of the possible equilibria of the model, we compute the threshold quantity. The linearization and Lyapunov function theory are used to derive conditions for the stability analysis of the possible equilibrium states. We present numerical simulations to support our investigations. The simulations are compared with the available real data for Wuhan city in China, where the infection was initially originated.