Evaluation of antioxidant potential of medicinal plants from Malaysian Rubiaceae (subfamily Rubioideae)

Ahmad, Rohaya; Mahbob, Emi Norzehan Mohamad; Noor, Zainon Mohd; Ismail, Nor Hadiani; Lajis, Nordin Hj; Shaari, Khozirah

doi:10.5897/ajb09.967

Cited by 18 publications

(9 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The total phenolic content of the M. pendens tubers using the ethanol solvent was 330.61 ± 2.13 mg GAE/g. In addition, Ahmad et al (2010) reported that the total phenolic content in 22 kinds of medicinal herbs from the Malaysian Rubiaceae family (subfamily Rubioideae) showed that Hydnophytum formicarum which had a close relative of Myrmecodia (but a different genus) possessed the highest total of phenolic contents compared to other plants (120.63 ± 3.09 mg GAE/g). …”

Section: Total Of Phenolic Content (Tpc)mentioning

confidence: 99%

“…In a study conducted by Soeksmanto et al (2010), it was reported that the extract of ant-plants (M. pendens) could inhibit the growth of cervical and breast cancer cells (HeLa and MCM-B2 cells). Ahmad (2010) also stated that a total of high phenolic contents and antioxidant activity (AOA) of Hydnophytum formicarum could be used as an anti-oxidant and anti-microbial agent (Prachayasittikul et al 2008).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Short Communication: The potential of secondary metabolites of Myrmecodia tuberosa from different host trees

Sari¹,

Kustiawan²,

Sukartiningsih³

et al. 2017

Nusantara Biosci

View full text Add to dashboard Cite

Abstract. Sari YP, Kustiawan W, Sukartiningsih, Ruchaemi A. 2017. Short Communication: The potential of secondary metabolites of Myrmecodia tuberosa from different host trees. Nusantara Bioscience 9: 170-174. Ant-plants (Myrmecodia tuberosa Jack.) is a medicinal plant that could potentially inhibit cancer cell growth. Ant-plants is epiphytic plants whose commonly life was attached to the host tree. Several information from local people stated that ant-plants attaching to different host trees possesses different active compounds. The purpose of this study was to determine the secondary metabolites of each parts of ant-plants including leaves, stems and tubers from different tree hosts i.e mango and durian. Result from phytochemical analysis showed that ant-plants living in mango and durian trees positively contained the metabolic compounds including phenolics, flavonoids, alkaloids, saponins and steroid/triterpenoid. The Total of Phenolic Content (TPC) and the Total of Flavonoids Content (TFC) on the leaves of ant-plants was higher than that in tubers or stems of ant-plants derived from both host trees i.e mango and durian. The value of TPC and TFC of the ant-plants leaves derived from the durian host tree (319.33 ± 0.06 mg GAE/g and 272.33 ± 0.02 mg CE/g) was higher than those from mango host trees (172.80 ± 0.02 mg GAE/g and 162,83 ± 0.01 mg CE/g). Ant-plants, whose life was attached to a different host tree, had the same content of secondary metabolites although those quantities were different in each host trees. Therefore, ant-plants from different host trees could be used as a medicinal plant by concerning the amount of used extract for effectiveness medicinal purposes.

show abstract

Section: Total Of Phenolic Content (Tpc)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Short Communication: The potential of secondary metabolites of Myrmecodia tuberosa from different host trees

Sari¹,

Kustiawan²,

Sukartiningsih³

et al. 2017

Nusantara Biosci

View full text Add to dashboard Cite

show abstract

“…Myrmecophytes used as medicine belong to Hydnophytum and Myrmecodia genera. Phytochemical analysis showed that Myrmecophyte tubers contain of flavonoids and tannins which have the properties of antiproliferative (Senawong et al, 2013), anticancer (Abdullah et al, 2010), antimicrobe (Ahmad et al, 2010), antioxidant (Dirgantara et al, 2013), antiinflammation, antiparasite, antimalarial, and antifungal (Musman et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Diversity and Distribution of Myrmecophytes in Bengkulu Province

2017

View full text Add to dashboard Cite

Myrmecophyte is a common medicinal plant used by local people in Indonesia for treating various diseases especially in Papua. Bengkulu province is one of the Myrmecophyte habitats, but there has no report on its identity and distribution. The objectives of this research were to identify the diversity and analyze the Myrmecophytes distribution as well as factor affecting its presence. This study used purposive sampling method by exploring the area where Myrmecophytes commonly found. The Myrmecophyte distribution based on host tree was analyzed using Morishita index and the autecological analysis of abiotic factors was performed using Principal Component Analysis (PCA) generated from Minitab 16. The results of this research showed that there were two species of Myrmecophytes in Bengkulu province, namely Hydnophytum formicarum and Myrmecodia tuberosa, as well as two variants of M. tuberosa i.e. M. tuberosa 'armata' and M. tuberosa 'siberutensis'. The distribution of Myrmecophytes based on host tree was mostly randomly scattered in Central Bengkulu regency, Seluma, North Bengkulu, South Bengkulu, and Kaur. Their distributions were affected by light intensity and temperature. The data of this research can be used as basic information for carried out conservation efforts in Bengkulu province. The abundance of Myrmecophytes is also used as a source of additional income for local people in Bengkulu province.

show abstract

“…The Rubiaceae family (Madder family) is one of the largest of the angiosperms with more than 637 genera and almost 10,700 species [1] . The genus Nauclea which belongs to this family, consists of about 35 species worldwide [2] and in Malaysia, there are two Nauclea species; N. officinalis and N. subdita [3] .…”

Section: Introductionmentioning

confidence: 99%

Subditine, a New Monoterpenoid Indole Alkaloid from Bark of Nauclea subdita (Korth.) Steud. Induces Apoptosis in Human Prostate Cancer Cells

et al. 2014

View full text Add to dashboard Cite

In this study, a new apoptotic monoterpenoid indole alkaloid, subditine (1), and four known compounds were isolated from the bark of Nauclea subdita. Complete 1H- and 13C- NMR data of the new compound were reported. The structures of isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2D- NMR, IR, UV and LCMS. All five compounds were screened for cytotoxic activities on LNCaP and PC-3 human prostate cancer cell-lines. Among the five compounds, the new alkaloid, subditine (1), demonstrated the most potent cell growth inhibition activity and selective against LNCaP with an IC50 of 12.24±0.19 µM and PC-3 with an IC50 of 13.97±0.32 µM, compared to RWPE human normal epithelial cell line (IC50 = 30.48±0.08 µM). Subditine (1) treatment induced apoptosis in LNCaP and PC-3 as evidenced by increased cell permeability, disruption of cytoskeletal structures and increased nuclear fragmentation. In addition, subditine (1) enhanced intracellular reactive oxygen species (ROS) production, as reflected by increased expression of glutathione reductase (GR) to scavenge damaging free radicals in both prostate cancer cell-lines. Excessive ROS could lead to disruption of mitochondrial membrane potential (MMP), release of cytochrome c and subsequent caspase 9, 3/7 activation. Further Western blot analyses showed subditine (1) induced down-regulation of Bcl-2 and Bcl-xl expression, whereas p53 was up-regulated in LNCaP (p53-wild-type), but not in PC-3 (p53-null). Overall, our data demonstrated that the new compound subditine (1) exerts anti-proliferative effect on LNCaP and PC-3 human prostate cancer cells through induction of apoptosis.

show abstract

Evaluation of antioxidant potential of medicinal plants from Malaysian Rubiaceae (subfamily Rubioideae)

Cited by 18 publications

References 29 publications

Short Communication: The potential of secondary metabolites of Myrmecodia tuberosa from different host trees

Short Communication: The potential of secondary metabolites of Myrmecodia tuberosa from different host trees

Diversity and Distribution of Myrmecophytes in Bengkulu Province

Subditine, a New Monoterpenoid Indole Alkaloid from Bark of Nauclea subdita (Korth.) Steud. Induces Apoptosis in Human Prostate Cancer Cells

Contact Info

Product

Resources

About