Evaluation of antioxidant potentials ofMorinda morindoidesleaf extract

Abstract

This study investigated antioxidant status of animals given aqueous extract of Morinda morindoides leaves using the levels of reduced glutathione, total-thiol, vitamin C, and vitamin E as well as malondialdehyde concentrations as indices, and its in vitro antioxidant capacity. Thirty rats divided into five groups were used. Group A served as control and were administered distilled water while groups B, C, D, and E were given 100, 200, 400, and 800 mg per kilogram body weight of water-extracted constituents of M. morindoides for 28 days. Total phenolic compounds amounted to 83.6 § 5.9 mg g ¡1 gallic acid equivalent, while total flavonoid content was 9.5 § 0.9 mg g ¡1 pyrocathecol equivalent. Malondialdehyde in plasma was significantly decreased in a dose-dependent manner, ranging from 21% in groups B and C to 84% in groups D and E. Vitamins C and E were significantly increased, in group E by 91% and 17% compared with control. Total thiols and glutathione in plasma were significantly increased, with group E having 2.5-fold and 4.2-fold higher values than control.

Phenylpropanoid-conjugated iridoid glucosides from leaves of Morinda morindoides

“…As a result, the three phenylpropanoid-conjugated iridoid glucosides named: acetylgaertneric acid (1), acetyldehydrogaertneroside (2), and dehydrogaertneric acid (10), together with 15 known compounds were isolated and identified by comparing their spectroscopic data with those in the literature. These included 9 phenylpropanoid-conjugated iridoid glucosides, acetylgaertneroside (3), gaertneroside (6), dehydrogaertneroside (7), methoxygaertneroside (8), dehydromethoxygaertneroside (9), epoxygaertneroside (11), epoxymethoxygaertneroside (12) [3], morintoside B (4) [23], and dehydroepoxymethoxygaertneroside (5) [23][24][25]; two alkaloids, N-[4′-hydroxy-3′-methoxy-(E)-cinnamoyl]-L-glutamic acid (13) [26] and (Z)-N-(p-coumaroyl)-glutamic acid (14) [27]; one benzenoid, 3,4-dihydroxybenzoic acid (15) [28]; and three flavonoid glucosides, kaempferol 3-rutinoside (16) (18) [31] (Fig. 1).…”

“…A decoction prepared from the leaves of Morinda morindoides (Baker) Milne Redhead (Rubiaceae), which is distributed in Western and Central Africa, is a traditional medicine to treat a number of disorders, including malaria, fever, and diabetes [1]. The leaf extracts of this plant have been reported to show anti-protozoal [2,3], anti-diarrheal [4], hypotensive [5], spasmolytic [6], anti-hyperglycemic [7], antioxidant [8,9], cytotoxic [10], larvicidal [11], and anti-malarial [12] activities. Phenylpropanoid-conjugated iridoid glucosides have been reported to be active against malaria.…”

“…To make matters even worse, there is no vaccine available for Chagas disease [15,16]. Compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) isolated during the ongoing study to identify anti-malarial compounds in M. morindoides leaves, as well as compounds (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) isolated during a previous study, were investigated for antitrypanosomal activity against T. cruzi.…”

Novel insights into the fruit and seed extracts ofMorinda morindoides(Baker) Milne‐Redh: HPLC‐ESI‐Q‐TOF‐MS profiling, antioxidant, and enzyme inhibitory propensities

“…(Rubiaceae) (Synonym: Gaertnera morindoides Baker or Morinda confusa Hutch) is one of the most popular and common medicinal plants in Africa, especially in the subtropical countries (Cimanga et al, 2010). Morinda morindoides is commonly known as “ponju owiwi” in Yoruba (Southwest, Nigeria), as “kongobolo” in the Republic of Congo, “zeleke” in Ivory Coast, and brimstone tree in English (Akinloye, Sunmonu, Omotainse, & Balogun, 2015; Idowu, Soniran, Ajana, & Aworinde, 2010; Olukunle, Abatan, Adenubi, & Amusan, 2013). An infusion of the fresh leaves is the typical remedy for the traditional treatment of malaria (Tona et al, 2001), diarrhea, gonorrhea, hemorrhoids, amebiasis, and rheumatism (Cimanga et al, 2010; Kambu, Tona, Luki, Cimanga, & Uvoya, 1990; Marie‐Genevieve, Robin, Gregory, Catherine, & Claudie, 2010).…”