Evaluation of antioxidant status and oxidative stress in cattle naturally infected with Theileria annulata

Rezaei, Siamak Asri; Dalir‐Naghadeh, Bahram

doi:10.1016/j.vetpar.2006.05.033

Cited by 91 publications

(54 citation statements)

References 36 publications

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“…Thus, it can be suggested that the invasion of RBCs by the parasites could markedly affect key antioxidant defense barriers, resulting in significant RBC damage and finally leading to extravascular hemolysis. Our data corroborate the previous studies on bovine tropical theileriosis (Rezaei and Dalir-Naghadeh, 2006;Nazifi et al, 2009), but Grewal et al (2005) reported that the GPX activity was significantly elevated whereas the enzymes SOD and catalase showed no remarkable changes in cattle infected with T. annulata. They concluded that the increased level of GPX during the infection could be due to the fact that this enzyme activity is the major mechanism for the intracellular destruction of lipid peroxides rather than SOD or catalase activity, while our findings showed that, parallel to the role of GPX, the activities of SOD and catalase could also be important factors for RBCs to scavenge the oxidant agents during the parasitemia.…”

Section: Discussionsupporting

confidence: 93%

“…Also, despite previous studies on bovine tropical theileriosis pointing out an immune-mediated hemolysis indicated by the presence of a hemagglutinin in T. annulata infected calves (Hooshmand-Rad, 1976), some recent findings suggest that anemia could be a consequence of the oxidative damage of RBCs, as well as significant modulation of erythrocytic antioxidant enzymes activities (Shiono et al, 2003;Rezaei and Dalir-Naghadeh, 2006;Nazifi et al, 2008). On the other hand, other studies have suggested that erythrocyte destruction during oxidative stress was related to lipid peroxidation of the RBCs (Friedman, 1979;Grewal et al, 2005).…”

Section: Introductionmentioning

confidence: 94%

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Correlations Among the Level of Homocysteine, Antioxidant Enzymes, Antioxidant Vitamins and Lipid Peroxidation of Erythrocytes in Malignant Ovine Theileriosis

Razavi¹,

Nazifi²,

Mokhtari³

et al. 2015

Research J. of Parasitology

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Malignant ovine theileriosis is a fatal disease of sheep caused by Theileria hirci. The present study was designed to estimate the levels of plasma Homocysteine (Hcy), antioxidant enzymes, antioxidant vitamins and lipid peroxidation of erythrocytes and also to evaluate their correlations in different parasitemia rates in naturally infected sheep. Fifty Iranian sheep, about 1-2 years old, naturally infected with T. hirci were selected and divided into 2 subgroups according to their parasitemia rates (<2%, 2-4%). Ten non-infected animals were also selected as controls. Blood samples were collected and Hcy, antioxidant enzymes, antioxidant vitamins and lipid peroxidation of erythrocytes were measured. Our results showed that the activities of erythrocytic antioxidant enzymes including SOD, GPX and catalase were substantially reduced in infected sheep. Furthermore, the animals with higher parasitemia rate showed remarkable declines in SOD, GPX and catalase activities. There was a significant rise in the level of MDA, particularly in the animals with the higher (2-4%) parasitemia rates. In addition, it was evident that coinciding with the elevation of the parasite-bearing erythrocytes in infected animals, the level of lipid peroxidation in RBC membrane was significantly increased. Although the concentration of vitamin C showed a significant decrease in infected sheep with <2% parasitemia rate, the concentrations of antioxidant vitamins (A and E) generally showed no remarkable alterations. In our study, a significant increase was evident in the level of homocysteine in sheep suffering from theileriosis. Our data also showed that the increase in of parasitemia was coupled with the elevation of homocysteine level (r = 0.34, p<0.05).

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 94%

Correlations Among the Level of Homocysteine, Antioxidant Enzymes, Antioxidant Vitamins and Lipid Peroxidation of Erythrocytes in Malignant Ovine Theileriosis

Razavi¹,

Nazifi²,

Mokhtari³

et al. 2015

Research J. of Parasitology

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“…Highly reactive oxygen free radicals have a role in the pathogenesis of various parasitic infections including Babesia, Leishmania, Hepatozoon, Ehrlichia, Theileria and Plasmodium parasites (Murase et al, 1995;Bildik et al, 2004;Kiral et al, 2005;Kumar et al, 2006;Rezaei and Dalir-Naghadeh, 2006). However, to the best of our knowledge, levels of serum MDA have not been previously reported in dogs infected with B. canis.…”

Section: Discussionmentioning

confidence: 75%

“…This early change was hypothesized to be caused by hemodilution, splenomegaly and sequestration in the spleen (Maegraith et al, 1957;Schetters et al, 1997aSchetters et al, , 1998Schetters et al, , 2009). This mechanism may include autoimmune haemolysis (Reyers et al, 1998), reduced red cell deformability (Dondrop et al, 1999) and increased oxidative damage (Murase et al, 1995;Morita et al, 1996;Otsuka et al, 2001;Rezaei and Dalir-Naghadeh, 2006). A possible role of the highly reactive oxygen free radicals in the pathogenesis of parasitic infections has been an active area of research over the past ten years (Biswas et al, 1997;Erel et al, 1997;Oliveira and Cechini, 2002).…”

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confidence: 99%

Malondialdehyde levels in serum of dogs infected with Babesia canis

Crnogaj¹,

Petlevski²,

Mrljak³

et al. 2010

Vet. Med.

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Babesiosis is a common tick born disease of dogs in tropical and subtropical regions of the world caused by different species of Babesia. The aim of the present study was to confirm the presence of oxidative stress by examining serum malondialdehyde (MDA), an end product of lipid peroxidation, in 35 dogs naturally infected with Babesia canis (B. canis). MDA was examined in 14 healthy dogs as well. Blood smears were prepared from peripheral blood and they showed the presence of B. canis in infected dogs. B. canis was confirmed using the PCR (Polymerase chain reaction) method. On the basis of clinical and laboratory data the 35 infected dogs were clinically classified into two groups, complicated (seven dogs) and uncomplicated (28 dogs). The noted complications were renal dysfunction (5/7), hepatic dysfunction (3/7), muscular involvement (2/7) and ARDS (1/7). Levels of blood urea nitrogen concentration (BUN), creatinin, total bilirubin, alanin aminotranspherase (ALT), alkaline phosphatase (AP), and gammaglutamil aminotranspherase (GGT) were significantly increased in dogs with complicated versus uncomplicated babesiosis. Furthermore the uncomplicated group of dogs was, depending on the severity of anaemia, classified as suffering from severe, moderate or mild disease. Levels of serum MDA were significantly higher in sick dogs (36.90 μmol/l ± 13.95) than healthy animals (8.13 μmol/l ± 1.78). There was no significant statistical difference in serum MDA levels between dogs with complicated (38.48 μmol/l ± 12.11) and uncomplicated babesiosis (36.50 μmol/l ± 14.55). Comparison of the groups based on the severity of anaemia showed that there was no significant statistical difference in serum MDA levels between them. The study demonstrated the involvement of oxidative damage in dogs naturally infected with B. canis.

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“…Lipid peroxidation is a general mechanism whereby free radicals induce tissue damage, and is implicated in several diverse pathological conditions (Asri-Rezaei and Dalir-Naghadeh 2006). Lipids especially polyunsturated fatty acids (PUFA) are sensitive to oxidation, leading to the term lipid peroxidation or the thiobarbituric acid reactive substances (TBARS), of which, malondialdehyde (MDA) is the most abundant (Crnogaj et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Status of lipid peroxidation and antioxidant enzymes in goats naturally infected with Babesia ovis

Esmaeilnejad

Tavassoli

Asri‐Rezaei

et al. 2012

Acta Parasitologica

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This study aimed to assess lipid peroxidation and antioxidant enzymes in goats naturally infected with Babesia ovis. Red blood cell count (RBC), hemoglobin (Hb) concentration, packed cell volume (PCV), malondialdehyde (MDA) concentration, erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) activities and total antioxidant capacity (TAC) were determined in 15 goats naturally infected with B. ovis as well as same number of healthy goats. The parasitological diagnosis was confirmed using polymerase chain reaction (PCR) analysis by amplifying a partial 18S rRNA gene sequence of B. ovis. Percentage of parasitemia varied from 0.01 to 1%. The activities of erythrocyte GSH-Px, SOD, CAT and TAC were significantly lower (p<0.05) in the infected goats than in healthy ones. MDA concentration in erythrocytes of infected goats was significantly higher in infected goats than in healthy ones (p<0.05). Severity of parasitemia showed a positive correlation with the MDA and negative correlation with PCV, SOD, CAT, GSH-Px and TAC. Also, MDA was negatively correlated with PCV, SOD, CAT, GSH-Px and TAC. The results of this study suggested that oxidative damage to RBCs may contribute to the pathogenesis of anemia in caprine babesiosis.

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Evaluation of antioxidant status and oxidative stress in cattle naturally infected with Theileria annulata

Cited by 91 publications

References 36 publications

Correlations Among the Level of Homocysteine, Antioxidant Enzymes, Antioxidant Vitamins and Lipid Peroxidation of Erythrocytes in Malignant Ovine Theileriosis

Correlations Among the Level of Homocysteine, Antioxidant Enzymes, Antioxidant Vitamins and Lipid Peroxidation of Erythrocytes in Malignant Ovine Theileriosis

Malondialdehyde levels in serum of dogs infected with Babesia canis

Status of lipid peroxidation and antioxidant enzymes in goats naturally infected with Babesia ovis

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