Evaluation of antiplaque activity of Azadirachta indica leaf extract gel—a 6-week clinical study

Pai, M. Radhika; Acharya, Leelavathi D; Udupa, N.

doi:10.1016/j.jep.2003.09.035

Cited by 179 publications

(124 citation statements)

References 17 publications

(19 reference statements)

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“…Although pharmaceutical companies have produced a number of antimicrobial drugs in recent years, the development of bacterial super resistant strains to antimicrobial drugs in use has attracted the attention of the scientific community regarding the search for new cost-effective agents from natural sources (Höfling et al, 2010;Pai et al, 2004). Therefore, there is renewed interest in natural sources with antimicrobial activities to develop antibacterial agents.…”

Section: Antimicrobial Activities Of Siberian Ginseng Fruit Extractmentioning

confidence: 99%

Composition, antioxidant and antimicrobial activities of Eleutherococcus senticosus fruit extracts

Jang¹,

Lee²,

Eom³

et al. 2016

J App Pharm Sci

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This study was designed to examine the in vitro antioxidant and antimicrobial activities of essential oil and crude methanolic (MeOH) extract of Eleutherococcus senticosus (common name, Siberian ginseng) fruit and its partitioned fractions, including hexane, ethyl acetate (EtOAc), n-butanol (BuOH) and aqueous. 1,1-dephenyl-2-picryl-hydrazyl free radical scavenging and reducing power assay suggest that antioxidant activity of EtOAc and BuOH fractions is due to the reducing ability of the antioxidant against oxidative effects of reactive oxygen species. In addition, the essential oil of Siberian ginseng fruit showed remarkable antimicrobial activity against Kocuria rhizophila (MIC = 125 µg/ml), Micrococcus luteus (MIC = 500 µg/ml), and Escherichia coli (MIC = 63 µg/ml). The chemical compositions of the essential oil obtained by the simultaneous steam-distillation and extraction method were analyzed using GC-MS; trans-caryophyllene (21.7%), humulene (7.4%), bicyclogermacrene (6.0%), (+) spathulenol (4.5%), germacrene-D (3.2%), tau-muurolol (2.5%) and deltacadinene (2.3%) were found as main constituents. Furthermore, HPLC analysis identified ursolic acid as one of the principal components in Siberian ginseng fruit extract. Although this study has been carried out by in vitro assay, these results suggest that Siberian ginseng fruit may be a good candidate as a source of antioxidant and antimicrobial ingredients.

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Section: Antimicrobial Activities Of Siberian Ginseng Fruit Extractmentioning

confidence: 99%

Composition, antioxidant and antimicrobial activities of Eleutherococcus senticosus fruit extracts

Jang¹,

Lee²,

Eom³

et al. 2016

J App Pharm Sci

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“…In fact there is an overwhelming number of studies on the biological activities of plants and their natural product derivatives (8)(9)(10). Essential oils and their derivatives are one such example (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

“…Natural products have been recently investigated more thoroughly as promising agents for the prevention of oral diseases, especially plaque-related diseases such as dental caries (10,16). The increasing resistance to available antimicrobials has attracted the attention of the scientific community regarding a search for new cost-effective drugs of natural or synthetic origin (10,11).…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial activity of the essential oil from Lippia sidoides, carvacrol and thymol against oral pathogens

Botelho

Nogueira

Bastos

et al. 2007

Braz J Med Biol Res

348

222

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Dental caries and periodontal disease are associated with oral pathogens. Several plant derivatives have been evaluated with respect to their antimicrobial effects against such pathogenic microorganisms. Lippia sidoides Cham (Verbenaceae), popularly known as "Alecrimpimenta" is a typical shrub commonly found in the Northeast of Brazil. Many plant species belonging to the genus Lippia yield very fragrant essential oils of potential economic value which are used by the industry for the commercial production of perfumes, creams, lotions, and deodorants. Since the leaves of L. sidoides are also extensively used in popular medicine for the treatment of skin wounds and cuts, the objective of the present study was to evaluate the composition and antimicrobial activity of L. sidoides essential oil. The essential oil was obtained by hydro-distillation and analyzed by GC-MS. Twelve compounds were characterized, having as major constituents thymol (56.7%) and carvacrol (16.7%). The antimicrobial activity of the oil and the major components was tested against cariogenic bacterial species of the genus Streptococcus as well as Candida albicans using the broth dilution and disk diffusion assays. The essential oil and its major components thymol and carvacrol exhibited potent antimicrobial activity against the organisms tested with minimum inhibitory concentrations ranging from 0.625 to 10.0 mg/mL. The most sensitive microorganisms were C. albicans and Streptococcus mutans. The essential oil of L. sidoides and its major components exert promising antimicrobial effects against oral pathogens and suggest its likely usefulness to combat oral microbial growth.

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“…Preparation of gel base as per Ingredient Chart 1 [16], [17], [18] Ingredient Chart 1 S.No Ingredients Quantity taken 1.…”

Section: 3mentioning

confidence: 99%

Evaluation of antifungal activity of gel based hand wash using Camellia sinensis (Green tea) and Myristica fragrans (Nutmeg)

Johny¹

2013

IOSR-JPBS

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Evaluation of antiplaque activity of Azadirachta indica leaf extract gel—a 6-week clinical study

Cited by 179 publications

References 17 publications

Composition, antioxidant and antimicrobial activities of Eleutherococcus senticosus fruit extracts

Composition, antioxidant and antimicrobial activities of Eleutherococcus senticosus fruit extracts

Antimicrobial activity of the essential oil from Lippia sidoides, carvacrol and thymol against oral pathogens

Evaluation of antifungal activity of gel based hand wash using Camellia sinensis (Green tea) and Myristica fragrans (Nutmeg)

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