Evaluation of antiplasmodial activity and cytotoxicity assays of amino acids functionalized magnetite nanoparticles: Hyperthermia and flow cytometry applications

Rodriguez, Anselmo Fortunato Ruiz; Santos, Caio Carvalho dos; Lüdtke‐Buzug, Kerstin; Bakenecker, Anna C.; Chaves, Yury Oliveira; Mariúba, Luís André Morais; Brandt, João Victor; Amantéa, Bruno Estevam; Santana, Ricardo Costa de; Marques, Rodrigo Fernando Costa; Jafelicci, Miguel; Morales, Marco A.

doi:10.1016/j.msec.2021.112097

Cited by 17 publications

(11 citation statements)

References 44 publications

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“…The same trend was observed for the peak at around 2θ = 30°. These peaks confirmed the presence of the MNPs in the GPM matrix, and the findings were in the range of documented values. , For thermal assessment (Figure S5C and Table S3), the pure MNPs were stable in the detected temperature range (25–300 °C). T g was slightly reduced with the increase in MNP concentrations, suggesting the mobility of the macromolecules in the amorphous regions, thus, to some extent, compromising its thermal stability .…”

Section: Resultssupporting

confidence: 70%

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Dual-Cross-Linked Magnetic Hydrogel with Programmed Release of Parathyroid Hormone Promotes Bone Healing

Long

Wang

et al. 2023

ACS Appl. Mater. Interfaces

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Intermittent delivery of parathyroid hormone (PTH) could effectively promote bone regeneration, but the need for daily injection administration has limited its further clinical applications. Exposure to magnetic stimulation could regulate cell fate to promote osteogenesis. Herein, we developed a magnetized hydrogel with programmed PTH release and simultaneous magnetic actuation to promote osteogenic commitment. Ag dual-cross-linked hydrogel was formulated as GelMA−PVA (GP) biphasic reservoir with magnetic nanoparticles (GPM) and PTH (GPMP). Macroscopic and microscopic characterizations were performed to optimize the formulations. In vitro release assessment confirmed the programmable release of PTH with a pulsatile profile primed via magnetization in the first 4 days and a sustained release, controlled by an optimized GP matrix, for over a month. Stimulated by an alternating magnetic field, the hydrogels displayed a zigzag-shaped pulsatile release profile, and the cumulative release was enhanced by 8, 28, and 18% in In40, Ab40, and In20Ab20 (loading 40 μg PTH via incorporation, absorption, and their combination) formulations, respectively, compared with the same formulations without magnetic stimulation. An in vitro cytocompatibility test showed that all formulations were biocompatible and that PTH addition significantly promoted the proliferation of MC3T3-E1 pre-osteoblasts. In vivo studies presented enhanced new bone regeneration with significantly improved bone volume and bone mineral density in GPM and GPMP groups (increased by 120 and 251% compared with those of non-treated control), confirming their osteogenic effects and accelerated bone healing. This newly developed GPMP sample provides simultaneous osteogenesis effects via the programmed release of PTH and magnetically promoted bone regeneration and is promising in the facilitation of bone healing and treatment of various delayed/non-union conditions without the burden of daily injection.

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Section: Resultssupporting

confidence: 70%

“…The initial compounds and the selected binary hydrogels were analyzed via FTIR, as shown in Figure S5D. MNP presented a characteristic band around 545 cm –1 , corresponding to Fe–O stretching due to the iron oxide phase . For the MNP hydrogels, this band was shifted to 557 cm –1 , indicating that MNP interacted with the GP matrix.…”

Section: Resultsmentioning

confidence: 99%

Dual-Cross-Linked Magnetic Hydrogel with Programmed Release of Parathyroid Hormone Promotes Bone Healing

Long

Wang

et al. 2023

ACS Appl. Mater. Interfaces

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“…Recently amino acids functionalized MNPs were tested as antiplasmodial tools against Plasmodium falciparum, an important pathogen that has been acquiring resistance to the usual drugs used for treatment [52]. Natural amino acids attached to NPs surface stabilize MNPs in physiological conditions, providing a solution for the MNPs aggregation, which, as mentioned above, is one of the main problems of these particles with a therapeutic potential.…”

Section: Hyperthermiamentioning

confidence: 99%

Magnetic Nanoparticles for Immune System Related Diseases Treatment

Baudou¹

2023

Magnetic Nanoparticles for Biomedical Applications

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Nanotechnology is a continuously rising field with different and varied purposes. Nanoparticles (NPs) are defined as particles between 1 and 100 nanometers in diameter, but within this classification larger particles can be incorporated up to 500 nm. Magnetic NPs (MNPs) are generally composed with magnetic elements such as nickel, cobalt and iron, and have the ability to be manipulated through a magnetic field. Recently, these have been the subject of numerous studies because their attractive properties for several potential applications. Among them, we can include its use for diagnosis and medical treatment (theragnosis). Due to their properties, MNPs could be used with the aim of developing immunomodulatory therapies and deal with infectious diseases, cancer, allergies, autoimmune diseases, etc. The use of MNPs provides a novel tool to manipulate the immune response towards a profile according to the proposed objectives. That is why this chapter describes the interaction of MNPs with the immune system as well as its possible applications in immunomodulatory therapies.

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“…O valor de coercividade para estas ferritas ocorre para campos baixos, Hc ≤ 10 3 A/m (Ewaldson e O'handley, 1942). As NPM's de Fe 3 O 4 são utilizadas em aplicações biotecnológicas e biomédicas devido à baixa toxicidade, estabilidade química e natureza não carcinogênica (Yuan et al, 2022), sendo utilizada em aplicações tais como: biosseparação (Rodriguez et al, 2021), hipertermia (Agrawal et al, 2021), ferrofluidos (Rivera Pedraza et al, 2021), carreador e transporte de fármacos, agente de contraste em ressonância magnética, radioterapia, transportador para as macromoléculas oligonucleotídeas e enzimas. A Fe 3 O 4 também tem sido utilizada em processos ambientais tais como o tratamento de águas residuais (Huo et al, 2021).…”

Section: Magnetitaunclassified

Novas tecnologias aplicadas à engenharia biomédica: Uma Contribuição à Engenharia de Tecidos

2022

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da UFCG. Atua no desenvolvimento de novos materiais via síntese química, atividades relacionadas à nanotecnologia e desenvolvimento de materiais para aplicação em eletro-eletrônica, catálise, materiais magnéticos, ópticos, nanocompósitos, biomateriais, membranas cerâmicas e marcadores biológicos. Possui experiência em síntese e caracterização de materiais, desenvolvimento de materiais magnéticos para aplicações em catálise, absorvedores de radiação eletromagnética, marcadores biológicos e dispositivos magnéticos moles. Participa como membro permanente do Programa de Pós-Graduação em Ciências e Engenharia de Materiais (conceito CAPES 5). Também atua na formação de recursos humanos participando ativamente dos programas de

show abstract

Evaluation of antiplasmodial activity and cytotoxicity assays of amino acids functionalized magnetite nanoparticles: Hyperthermia and flow cytometry applications

Cited by 17 publications

References 44 publications

Dual-Cross-Linked Magnetic Hydrogel with Programmed Release of Parathyroid Hormone Promotes Bone Healing

Dual-Cross-Linked Magnetic Hydrogel with Programmed Release of Parathyroid Hormone Promotes Bone Healing

Magnetic Nanoparticles for Immune System Related Diseases Treatment

Novas tecnologias aplicadas à engenharia biomédica: Uma Contribuição à Engenharia de Tecidos

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