Evaluation of antitumor activity of Artemisia capillaris extract against hepatocellular carcinoma through the inhibition of IL-6/STAT3 signaling axis

Jang, Eungyeong; Kim, So Young; Lee, Na Rae; Yi, Chae Min; Hong, Da Rong; Lee, Woo Seok; Kim, Jong Ho; Lee, Kyung Tae; Kim, Bum Joon; Lee, Jang Hoon

doi:10.3892/or.2016.5283

Cited by 18 publications

(5 citation statements)

References 28 publications

(24 reference statements)

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“…Link [Cm]) that possess anticancer properties. [11][12][13][14][15][16][17][18][19][20] FDY003 inhibits cancer cell proliferation and survival and induces apoptosis in cancer cells in vitro and in vivo. 21 FDY003 exerts therapeutic effects by modulating the activities of key regulators in the apoptotic signaling pathway, such as Bcl-2associated X protein (Bax) and caspase-3, in colorectal cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Systems Pharmacology Study of the Anticervical Cancer Mechanisms of FDY003

Lee¹,

Kang²,

Park³

et al. 2020

Natural Product Communications

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Increasing data support that herbal medicines are beneficial in the treatment of cervical cancer; however, their mechanisms of action remain to be elucidated. In the current study, we used a systems pharmacology approach to explore the pharmacological mechanisms of FDY003, an anticancer herbal formula comprising Lonicera japonica Thunberg, Artemisia capillaris Thunberg, and Cordyceps militaris (Linn.) Link, in the treatment of cervical cancer. Through the pharmacokinetic assessment of absorption-distribution-metabolism-excretion characteristics, we found 18 active compounds that might interact with 106 cervical cancer-related targets responsible for the pharmacological effects. FDY003 targets were significantly associated with gene ontology terms related to the regulation of cellular behaviors, including cell proliferation, cell cycle processes, cell migration, cell apoptosis, cell death, and angiogenesis. The therapeutic targets of the herbal drug were further enriched in various oncogenic pathways that are implicated in the tumorigenesis and progression of cervical cancer, including the phosphatidylinositol 3-kinase, mitogen-activated protein kinase, focal adhesion, human papillomavirus infection, and tumor necrosis factor signaling pathways. Our study provides a systematic approach to explore the anticancer properties of herbal medicines against cervical cancer.

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Section: Introductionmentioning

confidence: 99%

Systems Pharmacology Study of the Anticervical Cancer Mechanisms of FDY003

Lee¹,

Kang²,

Park³

et al. 2020

Natural Product Communications

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“…e herbal and bioactive components of FDY003 are known to function as anti-LC pharmacological agents. AcT represses survival, invasion, growth, angiogenesis, and migration of LC cells by blocking the PI3K/Akt and IL-6/signal transducer and activator of transcription (STAT) 3 pathways [141][142][143][144]. Cm exerts antisurvival, antigrowth, and antiangiogenic effects in LC cells [145,146].…”

Section: Discussionmentioning

confidence: 99%

Investigation of Anti-Liver Cancer Activity of the Herbal Drug FDY003 Using Network Pharmacology

Lee

Park³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Globally, liver cancer (LC) is the sixth-most frequently occurring and the second-most fatal malignancy, responsible for 0.83 million deaths annually. Although the application of herbal drugs in cancer therapies has increased, their anti-LC activity and relevant mechanisms have not been fully studied from a systems perspective. To address these issues, we conducted a system-perspective network pharmacological investigation into the activity and mechanisms underlying the action of the herbal drug. FDY003 reduced the viability of human LC treatment. FDY003 reduced the viability of human LC cells and elevated their chemosensitivity. There were a total of 16 potential bioactive chemical components in FDY003 and they had 91 corresponding targets responsible for the pathological processes in LC. These FDY003 targets were functionally involved in regulating the survival, proliferation, apoptosis, and cell cycle of LC cells. Additionally, we found that FDY003 may target key signaling cascades connected to diverse LC pathological mechanisms, namely, PI3K-Akt, focal adhesion, IL-17, FoxO, MAPK, and TNF pathways. Overall, this study contributed to integrative mechanistic insights into the anti-LC potential of FDY003.

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“…Hepatocellular carcinoma (HCC) requires effective treatment due to low 10% 5-year survival rate of this disease [23]. Increasing evidence indicates that A. capillaris can efficiently suppress the proliferation of human hepatoma cells, and ethanol extract of A. capillaris exhibits dose-dependent antiproliferative effects against Huh7 and HepG2 human hepatoma cells mediated by inhibition of cancer cell migration via interleukin-6 (IL-6)-dependent regulation of the signal transducer and activator of transcription 3 (STAT3) pathway [24]. In HepG2 human hepatocarcinoma cells, aqueous extract of A. capillaris inhibits nuclear translocation of NF-κB and blocks the degradation of I-κB alpha, leading to inhibition of inflammatory proteins, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and tumor necrosis factor (TNF)-alpha [25].…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris

et al. 2021

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Artemisia capillaris Thunb. (A. capillaris, Yin-Chen in Chinese) is a traditional medicinal herb with a wide spectrum of pharmacological properties ranging from effects against liver dysfunction to treatments of severe cirrhosis and cancer. We used relevant keywords to search electronic databases, including PubMed, Medline, and Google Scholar, for scientific contributions related to this medicinal herb and the pharmacokinetics of its components. The pharmaceutical effects of A. capillaris contribute to the treatment not only of viral hepatitis, cirrhosis, and hepatocellular hepatoma, but also metabolic syndrome, psoriasis, and enterovirus in the clinic. The bioactive compounds, including scoparone, capillarisin, scopoletin, and chlorogenic acid, exhibit antioxidant, anti-inflammatory, antisteatotic, antiviral, and antitumor properties, reflecting the pharmacological effects of A. capillaris. The pharmacokinetics of the main bioactive compounds in A. capillaris can achieve a maximum concentration within 1 hour, but only chlorogenic acid has a relatively long half-life. Regarding the use of the A. capillaris herb by health professionals to treat various diseases, the dosing schedule of this herb should be carefully considered to maximize therapeutic outcomes while lessening possible side effects.

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Evaluation of antitumor activity of Artemisia capillaris extract against hepatocellular carcinoma through the inhibition of IL-6/STAT3 signaling axis

Cited by 18 publications

References 28 publications

Systems Pharmacology Study of the Anticervical Cancer Mechanisms of FDY003

Systems Pharmacology Study of the Anticervical Cancer Mechanisms of FDY003

Investigation of Anti-Liver Cancer Activity of the Herbal Drug FDY003 Using Network Pharmacology

The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris

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