Evaluation of aphrodisiac effect of vanillin in male wistar rats

Abstract

Introduction: Vanillin is one of the primary chemical components of the vanilla bean (Vanilla planifolia). An aphrodisiac is defined as any food or drug that arouses the sexual instinct, induces venereal desire and increases sexual pleasure and performance. Unpublished data claim that vanillin, taken under proper guidance, can help relieve problems of impotence, erectile dysfunction, frigidity, loss of libido and promotes arousal. Hence this study was conducted to study the potential aphrodisiac effects of vanillin in rats. Methods: Twenty four male rats were divided into four groups which received vehicle, vanillin 100 mg/kg/day, 200 mg/kg/day and 400 mg/kg/day orally, respectively. Female rats were brought to oestrous cycle by the sequential administration of estrogen (10 μg/100 g) and progesterone (0.5 mg/100 g) through intraperitoneal injections, 48 hours and 4 hours (respectively) prior to pairing with the male on day 1 to study the acute effects and on day10 to study the sub-chronic effects. Sexual behaviors were observed for three hours. Serum testosterone levels were estimated. The data was analyzed using one way ANOVA followed by posthoc tests. Results: There was a statistically significant increase in the mount frequency and intromission frequency compared to control following both acute and chronic treatment with vanillin (200 mg/kg). The mount latency, intromission latency, ejaculation latency and post-ejaculatory interval decreased in the vanillin treated groups especially at 200 mg/kg. There was no significant difference in the serum testosterone levels among the groups. Conclusion: Vanillin in the dose of 200 mg/kg demonstrated aphrodisiac properties in male wistar rats.

The most used medicinal plants by communities in Mahaboboka, Amboronabo, Mikoboka, Southwestern Madagascar

“…Several species were mentioned by local community for having aphrodisiac properties. Among them, three endemic species ( Cedrelopsis grevei , Vanilla madagascariensis and Neobeguea mahafaliensis ) were widely recognized for their aphrodisiac properties [ 15 , 37 , 52 , 60 – 65 ].…”

Evaluation the Effect of Novel L-arginine Derivative and Cadmium Chloride on Reproductive Efficiency in Male Rats.

“…It's known that the Cadmium causes stimulation of free radical releasing, which results in oxidative state of lipids, proteins and DNA, and starting of many pathological conditions in living organisms 51 . Exposure to cadmium, acute as well as chronic, is contact with trigger of lipid peroxidation in different tissues as liver, kidney, spleen, testes, lung, brain and erythrocytes 52,53 . Treatment with Cadmium chloride resulted in disorganization of germinal epithelium, impaired spermatogenesis, widening and congestion of interstitial space, this result is similar to result obtained by Mohamed et al 54 The mechanism of Cd by which it induced toxicity is oxidative status.…”