Evaluation of Aqueous Leaf Extract of Cissampelos mucronata on Testicular Function Indices in Wistar Rats

Olaolu, Tomilola D.; Akinwande, O.G.; Olaolu, Ayotunde

doi:10.9734/ijbcrr/2015/14318

Cited by 5 publications

(8 citation statements)

References 23 publications

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“…That this was significantly increased in the extract-treated animals is not only informative of increased secretory activity of the testes but also a substantive androgenic potential of CEAE. This is closely supported by the corresponding increases in the testicular levels of protein, cholesterol, glycogen and the assayed hormones (Table 4) in this study and agrees with the submission of Olaolu et al [35] that linked graded increase in testes-body weight ratio to treatment with standardized extract of Cissampelos mucronata in male rats.…”

Section: Treatmentssupporting

confidence: 93%

“…LH and FSH, produced by anterior pituitary lobe are necessary for maintaining testosterone levels such that as their testicular concentration increases so do the testosterone [45]. Specifically, testosterone is required for the growth and development of male reproductive organs and in association with FSH, acts on the seminiferous tubules to initiate and maintain spermatogenesis [35,46]. Similarly, LH exerts stimulatory effect on testosterone by binding on Leydig cells receptors to activate testosterone biosynthesis.…”

Section: Treatmentsmentioning

confidence: 99%

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Aqueous extract of Cyperus esculentus L. restores and boosts sexual competence in paroxetine-dysfunctioned male Wistar rats

Sabiu¹,

Ajani²,

Temitope³

et al. 2016

J Exp Integr Med

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Objective: To investigate Cyperus esculentus aqueous extract on paroxetine-mediated sexual dysfunction in male Wistar rats. Methods: Sexually dysfunctioned (SD) rats were orally treated with PowMaxM [reference drug (7.14 mg/kg)] and the extract (500 and 1000 mg/kg body weight) once daily for 10 days, and their sexual behavioural parameters were monitored and computed. Relative testes-body weight and testicular function parameters were also evaluated at the end of the treatment period. Results: Dim light observation on the animals revealed respective proceptive and precopulatory behaviours by the primed female animals and the extract-treated male rats. Compared with SD rats, the extracttreated groups significantly restored and improved sexual behaviour and libido as evident from the remarkably increased frequencies of mount, intromission, ejaculation and ejaculatory latency. In addition, the latencies of mount, intromission, and post-ejaculation were significantly reduced. The significantly reduced testicular activities of alkaline phosphatase, acid phosphatase, lactate dehydrogenase and the concentrations of protein, cholesterol, glycogen, testosterone, luteinizing hormone, follicle stimulating hormone and testes-body weight in the SD rats were also markedly increased following treatment with the extract. The effects elicited by the extract competed favourably with the reference drug used. The improved sexual competences exhibited by the male rats in this study are indicative of aphrodisiac attributes of the extract and could be adduced to the presence of phytonutrients as revealed by the GC-MS chromatogram. Conclusion: The data from this study suggest that C. esculentus is capable of restoring and boosting sexual competence and the probable mechanism is via synergistic influence of the adaptogenic bioactive principles.

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Section: Treatmentssupporting

confidence: 93%

Section: Treatmentsmentioning

confidence: 99%

Aqueous extract of Cyperus esculentus L. restores and boosts sexual competence in paroxetine-dysfunctioned male Wistar rats

Sabiu¹,

Ajani²,

Temitope³

et al. 2016

J Exp Integr Med

View full text Add to dashboard Cite

show abstract

“…There was also significant (P<0.05) decrease in the alkaline phosphatase, concentrations of acid phosphatase, and total testicular protein particularly in rats given with 1200 mg/kg body weight of the extracts, while the activities of gamma glutamyl transferase was no significantly change. Serum testosterone concentration was found to decrease significantly (P<0.05) when the rats were given with 300 mg/kg body weight of the extracts [84] …”

Section: Pharmacological Activitiesmentioning

confidence: 95%

Phytochemical Constituents and Biological Activities of Plants from the GenusCissampelos

Yan

et al. 2021

Chemistry & Biodiversity

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Cissampelos is a significant genus comprising of approximately 21 species of the medicinal plants (Menispermaceae). The plants of this genus are used in traditional medicine for the treatment of various ailments such as asthma, arthritis, dysentery, hyperglycemia, cardiopathy, hypertension and other related problems. These plants are rich in bioactive dibenzylisoquinoline and aborphine as well as small amounts of other ingredients. In recent years, the chemical constituents and pharmacological activities of Cissampelos genus have been paid more and more attention due to their diversity. Herein, we compile the chemical constituents and biological activities on this genus, and summarize the 13C‐NMR data of the main bioactive ingredients. All information comes from scientific databases such as Google Scholar, PubMed, Sci‐Finder, ScienceDirect, Web of Science and CNKI. It provides valuable data for the future research and development of Cissampelos genus.

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“…A decrease in the testicular protein level, which may imply decreased protein biosynthesis, could lead to a reduction in sperm maturation. The protein has been reported to be a vital requirement for sperm maturation and spermatogenesis (30). The restoration of protein concentration in the testes on cotreatment with the aqueous extract of Agnus castus leaves suggests the restoration of protein alterations.…”

Section: Experimental Group Experimental Group Experimental Group Experimental Groupmentioning

confidence: 99%

Effect of Co-administration of Agnus castus Aqueous Leaf Extract and Cadmium Chloride on Testicular Function Indices

Olaolu

Ajibola

Rotimi

et al. 2021

Jundishapur J Nat Pharm Prod

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Background: Cadmium toxicity is an environmental health menace in developing countries, which can result in damage to the male reproductive system. The mechanisms of cadmium toxicity include an increase in lipid peroxidation, depletion of glutathione, reduction in protein-bound sulfhydryl groups, and increase of oxidative stress. Agnus castus has been differently reported for its strong antioxidant potential and reproductive-enhancing properties. These two properties make the plant viable for the possible amelioration of cadmium toxicity. Objectives: This study was carried out to investigate the effect of Agnus castus aqueous leaf extract on the testicular function indices in cadmium chloride-treated rats. Methods: Twenty-five male Wistar rats (100 - 160) g, Rattus norvegicus strain, were randomly distributed into five different groups, each containing five animals. The animals were grouped as follows. Group A (control group) received distilled water, and group B received 6.5 mg/kg body weight of cadmium chloride. Groups C, D, and E received 6.5 mg/kg body weight of cadmium chloride each together with 50 mg/kg, 100 mg/kg, and 200 mg/kg body weight of aqueous extract of Agnus castus, respectively. The administration was done by oral gavage, once daily for 21 days. The animals were finally sacrificed on day 22. The serum was collected, and the testis was excised for testicular function indices, hormonal assays, and antioxidant activities. Results: Exposure to cadmium chloride caused a significant reduction (P < 0.05) in the weight of the testes and antioxidant enzymes (catalase, superoxide dismutase, and reduced glutathione) compared to the control group. However, co-treatment with cadmium chloride and Agnus castus leaves resulted in the amelioration of cadmium-induced reduction in testicular weight and antioxidant enzymes. Exposure to cadmium chloride caused a significant decrease in testosterone, follicle-stimulating hormone, and luteinizing hormone when compared to the control group. Co-treatment with cadmium chloride and Agnus castus increased the levels of glycogen, testosterone, follicle-stimulating hormone, and luteinizing hormone in the rats’ testes. Conclusions: The aqueous leaf extract of Agnus castus displayed a protective role in testicular function and antioxidants in Wistar rats against cadmium chloride toxicity, compared to control rats that received distilled water only.

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Evaluation of Aqueous Leaf Extract of Cissampelos mucronata on Testicular Function Indices in Wistar Rats

Cited by 5 publications

References 23 publications

Aqueous extract of Cyperus esculentus L. restores and boosts sexual competence in paroxetine-dysfunctioned male Wistar rats

Aqueous extract of Cyperus esculentus L. restores and boosts sexual competence in paroxetine-dysfunctioned male Wistar rats

Phytochemical Constituents and Biological Activities of Plants from the GenusCissampelos

Effect of Co-administration of Agnus castus Aqueous Leaf Extract and Cadmium Chloride on Testicular Function Indices

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