Evaluation of arterial-venous blood alcohol concentration gradients of ethanol administered by an infusion to dogs

Abstract

Numerous workers investigated ethanol pharmacokinetic. Therefore, the goal of the present study was not an investigation of ethanol pharmacokinetics; instead, the goal of the present study was to prepare further illustrative examples of a successful use of computational and modeling tools from system engineering in pharmacokinetic investigations. The previous study by Wilkinson and Rheingold published in October 1977 issue of the Journal of Pharmacokinetics, described an investigation of arterial-venous blood concentration gradients of ethanol administration by a constant rate intravenous infusion through indwelling venous catheters to dogs. The present study is a free continuation of the study by Wilkinson and Rheingold; therefore, the data available in the study by Wilkinson and Rheingold were used. An advanced modeling method, implemented in the computer program named CTDB, and described in the study by Dedik et al [1] was used for modeling purposes.