Evaluation of Atopic Dermatitis Improvement Caused by Low‐Level, Low‐Frequency Pulsed Electromagnetic Fields

Abstract

This study aimed to evaluate the effectiveness of using low‐level, low‐frequency pulsed electromagnetic field (LLLF_PEMF) stimulation to improve atopic dermatitis induced by 2,4‐dinitrochlorobenzene (DNCB). Twenty 6‐week‐old hairless mice were randomly divided into Normal (n = 5), PEMF 15 Hz (n = 5), PEMF 75 Hz (n = 5), and Sham (n = 5) groups. Following the onset of atopic dermatitis symptoms, PEMF groups (15 and 75 Hz) were stimulated with LLLF_PEMF (15 mT) for 8 h per day for 1 week. Sensory evaluation analysis revealed a significant difference between the PEMF 15 Hz group and Sham group (P < 0.05), but these differences were not visually obvious. While both the PEMF and Sham groups had atopic dermatitis lesions, lesion size was significantly smaller in the two PEMF groups than in the Sham group (P < 0.001). Additionally, changes in epithelial thickness because of skin inflammation significantly decreased for both PEMF groups, compared with the Sham group (P < 0.001). In conclusion, these results suggest that PEMF stimulation in vivo triggers electro‐chemical reactions that affect immune response. © 2022 Bioelectromagnetics Society.

Effect of Pulsed Electromagnetic Field Stimulation on Splenomegaly and IgE Levels in an DNCB-Induced Atopic Dermatitis Mouse Model

“…In the previous research, skin sections were stained with hematoxylin and eosin to observe the inflammation induced by leukocyte infiltration accompanied by keratinization [32]. Similar to the current findings, both the 15Hz and 75Hz PEMF groups exhibited a reduction in inflammation and lesion size comparable to the control group, while the Sham group displayed significantly greater inflammation thickness and larger lesions.…”

“…Capitalizing on these benefits, the non-perceptual nature of PEMF allows for conducting more objective and controlled experiments, minimizing stress-related variables that could skew the results. Histological analyses from prior research confirmed that PEMF stimulation had discernible anti-inflammatory and tissue regenerative effects in 2,4-dinitrochlorobenzene (DNCB)-induced AD models, emphasizing its therapeutic potential [32]. This evidence suggests that PEMF is not only a viable treatment modality for AD but also a catalyst for advancing our understanding of its underlying mechanisms and therapeutic pathways.…”

Pulsed Electromagnetic Field (PEMF) Treatment Ameliorates Murine Model of Collagen-Induced Arthritis

“…Antecedent studies suggested that PEMF pulse frequency effects on cells and tissues associated with RA range from 10 to 75 Hz [ 24 ]. Therefore, the pulse frequencies used in the experiment were set at 10 Hz (145 Gauss) or 75 Hz (85.9 Gauss), and the intensity was a mono-phasic stimulation of 15 mT (pulse duty ratio: 30%) [ 25 ]. The arthritic score for the CIA control group without PEMF treatment gradually increased after day 28 and reached 9.5 ± 1.06 by day 60 ( Figure 1 ).…”

“…munized twice with bovine type II collagen (days 0 and 21), and PEMF trea initiated 7 days after the second immunization, as detailed in Materials and Me tecedent studies suggested that PEMF pulse frequency effects on cells and tiss ated with RA range from 10 to 75 Hz [24]. Therefore, the pulse frequencies u experiment were set at 10 Hz (145 Gauss) or 75 Hz (85.9 Gauss), and the inten mono-phasic stimulation of 15 mT (pulse duty ratio: 30%) [25]. The arthritic sc CIA control group without PEMF treatment gradually increased after day 28 a 9.5 ± 1.06 by day 60 (Figure 1).…”

Case report: Successful immunomodulators combined with electromagnetic field therapy in a patient with methazolamide-induced Steven Johnson syndrome/toxic epidermal necrolysis overlap

“…The microcurrent produced under the magnetic field could stimulate living cells to reproduce and repair injured tissues. In addition, to provide pain relief (6), animal studies and clinical trials have shown the benefits of electromagnetic field therapy during the management of dermatitis, arthritis, and bone fracture (7)(8)(9).…”