Evaluation of autologous platelet-rich plasma plus ablative carbon dioxide fractional laser in the treatment of acne scars

Aal, Ahmed Mohammed Abdel; Ibrahim, Ibrahim Maeraj; Sami, Nevein Ahmed; Kareem, Ibrahim M Abdel

doi:10.1080/14764172.2017.1368667

Cited by 42 publications

(43 citation statements)

References 20 publications

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“…Abdel et al 23 conducted a similar study in which he treated 30 patients suffering from post-acne scars with ablative fractional CO2 laser (settings: 15 W, 600 ms dwell time, spading 700 μm, smart stack level 3); Only the right side of the face received intradermally injected autologous PRP (0.1 mL per point separated by 1–1.5cm). The laser was applied in two separate sessions (every 3–4 weeks) and patient’s follow-up was completed six months after the final laser session.…”

Section: Resultsmentioning

confidence: 99%

“… 8 Furthermore, two other level 2 studies provided contradictory results around the role of PRP in ameliorating post-fractional CO2 side effects including erythema resolution. 22 , 23 Some of the main limitations of the studies available in this arena include the small cohort sizes as well as their short follow-up period (range = 2–6 months); this is very limited given that the timescale of scar remodelling is considered to span over at least 12 months. Furthermore, the heterogeneity of treatment parameters (volume/concentration of PRP, laser settings, Fitzpatrick skin types) may render generalised conclusions challenging.…”

Section: Discussionmentioning

confidence: 99%

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The evidence behind the use of platelet-rich plasma (PRP) in scar management: a literature review

Alser

Goutos

2018

Scars, Burns & Healing

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Introduction:Autologous platelet-based concentrates represent increasingly popular adjuncts to a variety of medical, surgical and aesthetic interventions. Their beneficial potential rests on the ability to deliver a high concentration of growth factors to the target tissues. There are currently no reports in the literature appraising the evidence behind the use of platelet-rich plasma (PRP) in scar management.Methods:A detailed English literature review was conducted using PubMed Medline, Embase and Web of Science; the manuscripts were appraised and classified according to the Joanna Briggs Institute Levels of evidence. The results are presented in descending order of evidence separately for atrophic, keloid, surgical and traumatic scars.Discussion:On the basis of level 1 evidence currently available, it appears that PRP can improve the quality of atrophic acne scars treated with ablative fractional CO2 laser and decrease the duration of laser-related side effects including oedema and erythema. Regarding surgical scars, the current data suggest that PRP may improve wound healing and early scar quality; furthermore, incorporation of PRP in fat-grafting procedures undertaken in conjunction with non-ablative, fractional laser can contribute to better wound healing as well as a significant improvement in texture, colour and contour in traumatic scar resurfacing. There are no high level studies at present to support the incorporation of autologous platelet-based concentrates in the management of keloid scars.Conclusion:PRP is a promising adjunct in scar management practice. Further research with long-term follow-up is warranted to delineate the value of this modality in different subtypes of scars.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The evidence behind the use of platelet-rich plasma (PRP) in scar management: a literature review

Alser

Goutos

2018

Scars, Burns & Healing

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“…Platelet‐rich plasma works synergistically also with fractional carbon dioxide (CO 2 ) laser, erbium‐doped yttrium aluminum garnet (Er:YAG) laser, and autologous fat injections . Adding PRP was shown to increase tolerability and decrease downtime of laser modalities which makes PRP an appropriate therapy to include in multimodality regimens .…”

Section: Discussionmentioning

confidence: 99%

Combination therapy using subcision, needling, and platelet‐rich plasma in the management of grade 4 atrophic acne scars: A pilot study

Bhargava

Kroumpouzos

Varma

et al. 2019

J of Cosmetic Dermatology

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Summary Background Multimodality therapies including minimally invasive modalities are increasingly used in atrophic scarring. Objective To evaluate the role of platelet‐rich plasma (PRP) as adjunctive therapy to a combined subcision and needling treatment in severe (grade 4) atrophic acne scarring. Methods A total of 30 patients with grade 4 acne scars were randomly divided into two groups, 15 patients each: Group A underwent three sequential treatments of subcision and needling while Group B, three sequential treatments of subcision, needling, and topical application of PRP that were performed at 3‐week intervals. Scar grading was assessed 3 months following the final session. Participant's assessment of treatment response was registered. Results Scar improvement ≥50% was reported significantly more often by Group B than Group A patients (P = 0.025). Regarding physician‐based assessment of scar grading post‐therapy (number of patients with two grades improvement vs one grade or no improvement), there was a trend toward more improvement in Group B (P = 0.195). Physician's evaluation of acne scar improvement correlated with the patient's assessment of improvement: 60% of Group A and 66.6% of Group B patients appreciated an improvement of 25%‐49% and 50%‐74%, respectively. Mean duration of postprocedure erythema/edema was shorter among Group B than Group A patients (16.1 vs 32.9 hours, respectively). Overall, substantial improvement was noticed in rolling and boxcar scars with only a mild change in icepick scars. Conclusion Platelet‐rich plasma appears to add to the improvement of grade 4 atrophic acne scars when combined with needling and subcision. These findings require further evaluation by future studies.

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“…These reasons support the need to develop minimally invasive strategies, with no risk of toxicity, which are safe and do not generate adverse effects for skin healing. The use of PRP as a single therapy or with another concomitant treatment (microneedling, oral or topical antibiotics, and laser) has been proposed with satisfactory results (Abdel Aal, Ibrahim, Sami, & Abdel Kareem, 2018;Abuaf et al, 2016;Asif et al, 2016;Chawla, 2014).…”

Section: Prp and Acnementioning

confidence: 99%

“…As a control, they had a group treated with distilled water and microneedling, finding that the PRP combined with the microneedle technique is more effective in the treatment of atrophic acne scars than only microneedling (Asif et al, ). Abdel and colleagues observed that the use of intradermal PRP potentiates the effects of CO 2 laser therapy in the treatment of scars secondary to acne (Abdel Aal et al, ).…”

Section: The Prp In Dermatologymentioning

confidence: 99%

Platelet‐rich plasma, a powerful tool in dermatology

Merchán

Gómez

Chasoy

et al. 2019

J Tissue Eng Regen Med

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Platelet‐rich plasma (PRP), a platelet concentrate contained in a small volume of plasma, has become a promising option in the last decade to treat different diseases related to the skin due to its high concentration of growth factors. When it is of autologous origin, it decreases the probability of suffering adverse reactions and transfusion‐transmitted infections, thus it is an optimal and safe therapy for the patient. PRP has been used in the treatment of several dermatological conditions such as acne, alopecia, and skin ulcers. Its use has also extended to other skin conditions such as melasma, hyperpigmentation, and burns, where it stimulates tissue repair and regeneration. The purpose of this article is to review the management and treatment of different dermatological alterations with PRP. Although there are a variety of studies that support the use of PRP, more research is needed to standardise the protocols for obtaining, processing, and applying it as well as understanding the biological and molecular bases of its functioning.

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Evaluation of autologous platelet-rich plasma plus ablative carbon dioxide fractional laser in the treatment of acne scars

Abstract: Combination of fractional CO laser resurfacing and intradermal PRP was superior to CO laser alone for acne scar treatment.

Cited by 42 publications

References 20 publications

The evidence behind the use of platelet-rich plasma (PRP) in scar management: a literature review

The evidence behind the use of platelet-rich plasma (PRP) in scar management: a literature review

Combination therapy using subcision, needling, and platelet‐rich plasma in the management of grade 4 atrophic acne scars: A pilot study

Platelet‐rich plasma, a powerful tool in dermatology

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