Platelet‐rich plasma, a powerful tool in dermatology

Abstract

Platelet‐rich plasma (PRP), a platelet concentrate contained in a small volume of plasma, has become a promising option in the last decade to treat different diseases related to the skin due to its high concentration of growth factors. When it is of autologous origin, it decreases the probability of suffering adverse reactions and transfusion‐transmitted infections, thus it is an optimal and safe therapy for the patient. PRP has been used in the treatment of several dermatological conditions such as acne, alopecia, and skin ulcers. Its use has also extended to other skin conditions such as melasma, hyperpigmentation, and burns, where it stimulates tissue repair and regeneration. The purpose of this article is to review the management and treatment of different dermatological alterations with PRP. Although there are a variety of studies that support the use of PRP, more research is needed to standardise the protocols for obtaining, processing, and applying it as well as understanding the biological and molecular bases of its functioning.

Growth Factors Delivery System for Skin Regeneration: An Advanced Wound Dressing

“…The presence of these factors and of many others allow one to consider the PL not only a good substitute of FBS for in vitro cell cultures, but in particular a key player in the activation of in vivo regenerative processes. Platelet-derived products, such as PRP, PL, platelet gel, have been used to promote wound healing in the clinical practice for therapy of skin ulcers, osteoarticular regeneration, low back pain management and as antibacterial agent [36][37][38][39]. Considering the controversial literature data [40][41][42][43] on the effectiveness of the PRP, we figured that the inconsistency of the published results was most probably due to a poor quality of PRP produced by inadequate and uncontrolled procedures and to the extreme variability of the PRP product prepared from a single blood donation without considering the significant inter-individual variability in the platelet concentration of human plasma and the variability within the same individual, according to his health status.…”

Novel Approaches in Addressing Ovarian Insufficiency in 2019: Are We There Yet?

“…PRP has noted considerable success in various systems 51 – 55 . Following successful implementation of PRP in treating pathologies related to various systems, investigating the potential use of PRP in the context of the female reproductive system was anticipated.…”

Efficacy and Safety of Platelet-Rich Plasma in Melasma: A Systematic Review and Meta-Analysis

“…well above normal levels, obtained by centrifugation of autologous blood and subsequent suspension of platelets [9]. PRP has been used in the treatment of alopecia, hyperpigmentation, acne and other skin diseases [10]. It is well known that the platelet alpha granules in PRP are rich in growth factors, such as platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-b1 and TGF-b2 [11], which are associated with collagen production, wound healing and homeostasis control.…”