Evaluation of autonomic nervous system function in children with overactive bladder syndrome

Demir, Ayşegül; Gürsoy, Azize Esra; Göknar, Nilüfer; Uzuner, Selçuk; Özkaya, Enis; Erenberk, Ufuk; Vehapoğlu, Aysel; Dündaröz, Mehmet Ruşen; Öktem, Faruk

doi:10.1002/nau.22993

Cited by 6 publications

(5 citation statements)

References 24 publications

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“…For example, Fazeli et al, who evaluated 40 children with BBD and compared them to a control group of 19 children, reported less heart rate variability in patients with BBD (7). Likewise, Demir et al evaluated 40 children with OAB and 28 controls and showed greater heart rate variability during the Valsalva maneuver in participants of the control group (8). The sample size could have affected the ability of the study to detect a difference between some variables, increasing the likelihood of a type 2 error.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of autonomic function in children and adolescents with overactive bladder

et al. 2021

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Aims: To evaluate autonomic activity in children/adolescents with isolated overactive bladder. Materials and Methods: Descriptive, analytical, non-interventional, cross-sectional study conducted between February 2017 and January 2018 with individuals aged between 5 and 17 years old, with overactive bladder (OAB group) or asymptomatic (control). Neurological or anatomical abnormalities, diabetes mellitus and kidney failure constituted exclusion criteria. The DVSS and the Rome III questionnaire were applied, and heart rate variability (HRV) was assessed. The chi-square test, Student's t-test, ANOVA and the Mann Whitney U test were used in the statistical analysis. Results: 41 patients with OAB and 20 controls were included. In the OAB group, there were more girls (p=0.23), more overweight/obese and constipated patients. The DVSS score was higher in the OAB group. HRV showed a higher heart rate variability at the frequency domain and LF/HF variation in the control group (p=0.02 and p=0.05 respectively). In the intergroup evaluation, LF (Hz) was predominant in the control group at the post-voiding evaluation moment (p=0.03). Conclusion: The control group demonstrated a physiological heart rate variation during the voiding process, with a predominance of sympathetic activity during urinary storage.

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Section: Discussionmentioning

confidence: 99%

“…Demir et al analyzed 40 children with OAB and 28 controls. They revealed a better urinary dynamic function at the control group compared to the OAB group (8).…”

Section: Introductionmentioning

confidence: 92%

Evaluation of autonomic function in children and adolescents with overactive bladder

et al. 2021

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“…Patients with OAB may experience bladder dysfunction due to autonomic nervous system disorder. Multiple studies have evaluated ANS activity using neurophysiological diagnostic methods to test this hypothesis [20][21][22][23][24][25][26][27]:…”

Section: Digesu Et Al 2003 [16]mentioning

confidence: 99%

“…Ates et al demonstrated disrupted sympathetic function with OAB based on the skin sympathetic response test to assess sudomotor activity and function of thin unmyelinated sympathetic nerve fibers in the bladder and bladder neck [24,31].…”

Section: Digesu Et Al 2003 [16]mentioning

confidence: 99%

The importance of multimodal diagnostic methods for therapeutic decision making for overactive bladder in women

Ivanov,

Ceban

2024

Medicine and Pharmacy Reports

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Background and aim. Despite overactive bladder (OAB) being a symptomatic diagnosis, all patients require a basic assessment to confirm the diagnosis, as well as to exclude any other underlying cause for lower urinary tract dysfunction. While guidelines clearly define different methods of investigations for OAB, there are reasons to believe that these guidelines reflect more of a “one size fits all” model that may not be appropriate for use in all patients. The study aimed to elucidate the complex and advanced multidisciplinary methods of investigation of OAB patients. Methods. PubMed, ScienceDirect, Cochrane Library, and Google Scholar databases were used to search for scientific publications from 2013 to 2023 using relevant keywords and phrases. Results. Data from 708 publications were researched and synthesized, a systematic review was carried out and the detailed and coherent results presented the diagnostic aspects of overactive bladder in women. Relevant citations from selected articles were included, and a synthesis of key information was provided. Conclusion. These discoveries may assist in detecting OAB earlier, allowing for prompt intervention and potentially preventing the condition from progressing to more severe stages and providing healthcare professionals with valuable tools to enhance the diagnosis and treatment of OAB, potentially improving the quality of life for patients affected by this condition.

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“…In patients with idiopathic bladder dysfunctions (IB), neurological examinations fail to reveal any pathology in the nervous system. Diagnosis of IB is not so obvious, as some studies demonstrated various pathologies in the nervous system, such as parasympathetic hyperactivity in children diagnosed with idiopathic OAB syndrome, suggesting a neurogenic dysfunction in their autonomic nervous system [ 13 – 15 ].…”

Section: Causes Of Neurogenic Lower Urinary Tract Dysfunctionsmentioning

confidence: 99%

Pharmacotherapy for Pediatric Neurogenic Bladder

Kroll

2017

Pediatr Drugs

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Neurogenic bladder (NB) is a nonspecific term that may describe conditions ranging from areflectic noncontractile bladder to detrusor overactivity. The most common cause of NB in children is the presence of dysraphic malformations. Urodynamic evaluations make it possible to describe bladder dysfunctions and to plan a therapeutic strategy for each patient. In a child with NB there are two major dangerous functional problems seen in urodynamic investigations: high intravesical pressure in the storage phase and high pressure during urination. The basic goals of urologic treatment for a child with NB are the protection of the urinary tract from complications and improvement of continence. Treatment for a child with NB is usually conservative, and focuses on achieving safe bladder pressures during storage with reliable emptying, via voiding or catheterization. The two most important forms of conservative treatment are clean intermittent catheterization and pharmacological treatment of functional disorders. Some drugs are used in the treatment of functional disorders in children with NB, but none of the drugs are officially approved for small children and babies.

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Evaluation of autonomic nervous system function in children with overactive bladder syndrome

Abstract: This study demonstrated a parasympathetic hyperactivity in children with OAB, results suggesting a dysfunction in their autonomic nervous systems. Neurourol. Urodynam. 36:673-676, 2017. © 2016 Wiley Periodicals, Inc.

Cited by 6 publications

References 24 publications

Evaluation of autonomic function in children and adolescents with overactive bladder

Evaluation of autonomic function in children and adolescents with overactive bladder

The importance of multimodal diagnostic methods for therapeutic decision making for overactive bladder in women

Pharmacotherapy for Pediatric Neurogenic Bladder

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