2021
DOI: 10.1016/j.maturitas.2021.08.031
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Evaluation of basal bone mineral density (BMD) in premature ovarian insufficiency (POI) patients. Preliminary results. (Protocol code IIBSP-IOP-2012-109. ClinicalTrials.gov ID:NCT02068976)

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“…More and more menstruating women are experiencing endocrine dysfunction, infertility and other problems that put them under great physical and psychological strain. In addition, estrogen de ciency leads to irreversible skeletal dysplasia and metabolic abnormalities during puberty, resulting in retarded bone growth and abnormal fat distribution [2] . Therefore, the question of how to restore or preserve female endocrine and reproductive functions has gradually become a concern.…”
Section: Introductionmentioning
confidence: 99%
“…More and more menstruating women are experiencing endocrine dysfunction, infertility and other problems that put them under great physical and psychological strain. In addition, estrogen de ciency leads to irreversible skeletal dysplasia and metabolic abnormalities during puberty, resulting in retarded bone growth and abnormal fat distribution [2] . Therefore, the question of how to restore or preserve female endocrine and reproductive functions has gradually become a concern.…”
Section: Introductionmentioning
confidence: 99%