Evaluation of Basement Membrane Thickness of Somniferous Tubules in Cryptorchid Tests

Omar, Saif; Banerjee, P.; Deb, Samar

doi:10.18410/jebmh/2014/40

Cited by 2 publications

(1 citation statement)

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“…In testes, the seminiferous tubule basement membrane is especially important during spermatogenesis (51). The damage of this structure has been associated with many testicular pathological conditions such as cryptorchidism and orchitis as well as with the aging process (52). However, literature on the morphological alterations of the basement membrane during testicular aging are contradictory.…”

Section: Alterations In Basement Membranementioning

confidence: 99%

Testicular Aging: An Overview of Ultrastructural, Cellular, and Molecular Alterations

Santiago

Silva

Alves

et al. 2018

The Journals of Gerontology: Series A

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The trend in parenthood at an older age is increasing for both men and women in developed countries, raising concerns about the reproductive ability and the consequences for the offspring's health. While reproductive activity in women stops with menopause, a complete cessation of the reproductive potential does not occur in men. Although several studies have been published on the effects of aging on semen parameters and spermatozoa DNA integrity, literature on impact of aging on the testis, particularly cellular and molecular alterations, has been, so far, limited and controversial. This work discusses the current knowledge on testicular aging in humans and other mammals, covering topics from tissue ultrastructure, to cellular and molecular alterations. Aging affects male reproductive function at multiple levels, from sperm production and quality, to the morphology and histology of the male reproductive system. The morphological and functional changes that occur in the testes result in variations in the levels of many hormones, changes in molecules involved in mitochondrial function, receptors and signaling proteins. Despite knowing that these age-related alterations occur, their real impact on male fertility and reproductive health are still far from being fully understood, highlighting that research in the field is crucial.

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Section: Alterations In Basement Membranementioning

confidence: 99%