Evaluation of Biochemical and Clinical Parameters of Hypertension with Type 2 Diabetes Mellitus

Nicola, Patricia; Ardeleanu, Elena; Gadau, Carmen; Dorobanţu, Maria; Darabont, Roxana; Ţilea, Ioan; Varga, Andreea; Folescu, Roxana; Zamfir, Alexandra Simona; Boanca, Mihaela; Strat, Liliana; Baaj, Teim; Gurguş, Daniela

doi:10.37358/rc.18.9.6542

Cited by 10 publications

(10 citation statements)

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“…Multiple metabolic abnormalities often accompany primary hypertension with CKD [22,23]. Decreased HDL cholesterol, together with increased plasma levels of LDL cholesterol and VLDL, hypertriglyceridemia and insulin resistance are characteristic for hypertension with CKD.…”

Section: Resultsmentioning

confidence: 99%

Biochemical and Chemical Lipid Profile and Blood Pressure Assessment in Arterial Hypertension with Chronic Kidney Disease

Baaj¹,

Abu-Awwad²,

Botoca³

et al. 2020

Rev. Chim.

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Accelerated atherosclerosis and cardiovascular diseases are frequent complications in hypertensive patients with chronic kidney disease (CKD), being mainly driven by cardiovascular risk factors as lipid disorders and an unfavorable blood pressure profile. The objectives of the study were to evaluate the lipid profile and to assess the characteristics of blood pressure (BP) in patients with primary arterial hypertension associating chronic kidney disease (CKD) in a primary care population in Timis County, Romania. Lipid disorders were highly prevalent in hypertensive patients with CKD, consisting in hyper LDL-cholesterolemia in 50.3%, hypertriglyceridemia in 52%, low HDL-cholesterol levels in 35.8%. More than 2 lipid abnormalities were present in 68.8% of CKD hypertensive. CKD hypertensive patients, compared with those without CKD, presented a BP profile with higher systolic and diastolic office BP. On ambulatory blood pressure monitoring they also registred higher systolic and diastolic BP, the systolic BP (SBP), both for 24 h SBP, day-time and night-time SBP being statistically significant higher than in hypertensive patients without CKD. The circadian 24 h BP profile demonstrated in the CKD hypertensive population an unfavourable nocturnal profile in 67%, consisting of a high prevalence of the non-dipping profile and of nocturnal riser pattern.

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Section: Resultsmentioning

confidence: 99%

Biochemical and Chemical Lipid Profile and Blood Pressure Assessment in Arterial Hypertension with Chronic Kidney Disease

Baaj¹,

Abu-Awwad²,

Botoca³

et al. 2020

Rev. Chim.

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“…Tissue pretreatment with glutaraldehyde or formaldehyde are factors that promote the calcification of the extracellular matrix because they have a certain toxicity and do not allow to fix uniformly all the constituent elements of this matrix [6,[13][14][15][16]. Similar effects of glutaraldehyde and its derivatives have been described for medical devices also in other fields of interventional procedures [17,18] Various studies have hypothesized that the inflammatory and the immunological responses [19][20][21] could also play a role in the mineralization process of bioprosthetic tissues. Antibodies against donor valvular tissue components have been found in patients with structural deterioration of the bioprosthesis.…”

Section: Resultsmentioning

confidence: 99%

Early Degeneration of Aortic Bioprosthetic Valves Chemical interactions, prevention and treatment

Oancea¹,

Cobzeanu²,

Tarus³

et al. 2019

Rev. Chim.

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Bioprosthetic heart valves ensure a better quality of life compared to mechanical valves but are prone to degeneration with leaflet calcification and tearing. Valvular leaflets mineralization process is initiated within interstitial cells devitalized by glutaraldehyde with formation of calcium phosphate hydroxyapatite crystals. The aim of the current paper is to analyse early bioprosthetic valve degeneration occurring in three patients that needed bioprosthetic valve explantation and reimplantation of a mechanical valve. The three patients, aged 29, 64 and 78 years presented early degeneration of the implanted valve at 30, 36 and 52 months after the intervention in the context of unavoidable risk factors like young age, chronic kidney disease and small stented valve. Computed tomography examination demonstrated calcifications of the bioprosthetic valve and histological examination confirmed the findings by identifying tissue degeneration with calcification in all cases. Early bioprosthetic valve degeneration is a serious issue in cardiovascular surgery and a major cause of valve failure requiring reintervention. Several methods could be used to delay degeneration like systemic therapy with general anti-calcification agents, the use of locally delivered drugs or tissue pretreatment with special substances (ethanol, nonionic detergents, tridecyl alcohol ethoxylate). No optimal decellularization method for all types of tissues has been yet discovered. In conclusion, early bioprosthetic valve degeneration is a reality that should be taken into account in high risk patients. Current tissue pretreatment with glutaraldehyde is not perfect as it accelerates degeneration with formation of hydroxyapatite calcifications. New methods are needed to achieve efficient decellularization while preserving the functional characteristics of the transplanted tissue.

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“…Other chronic conditions associated with dermatological conditions, such as cancer, diabetes, cardiovascular disease, are alarm signals because patients have cumulative factors that predispose to suicide (16). Insomnia (or lack of sleep due to dermatological conditions) is another important factor to be considered in the suicidal risk assessment.…”

Section: Suicide In Dermatologymentioning

confidence: 99%

Assessment of suicidal behavior in dermatology (Review)

et al. 2019

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Many diseases that affect physical health can also affect mental health. Many of these diseases are studied in terms of quality of life, depression and suicidal behavior. Dermatological disorders, although having a strong impact on the individual's life, are less studied with regard to suicidal behavior. There is a need to approach several dermatological diseases from the perspective of suicidal behavior in order to intervene early with specific treatment or to prevent suicide. Psoriasis, acne, melanoma, atopic dermatitis and urticaria are scarcely studied from the point of view of suicidal behavior. In addition to these diseases, there are others that require attention in terms of suicidal behavior, such as vitiligo or oculocutaneous albinism, most probably due to a small number of people suffering from these diseases, research is almost non-existent in these cases. We want to draw attention to the importance of early detection of suicidal behavior in dermatological practice and to highlight the need for several studies on this subject. Contents 1. Introduction 2. Suicide in dermatology 3. Aspects of suicidal risk assessment in patients with dermatological diseases 4. Dermatological conditions with increased risk of suicidal behavior 5. Conclusions

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Evaluation of Biochemical and Clinical Parameters of Hypertension with Type 2 Diabetes Mellitus

Cited by 10 publications

References 0 publications

Biochemical and Chemical Lipid Profile and Blood Pressure Assessment in Arterial Hypertension with Chronic Kidney Disease

Biochemical and Chemical Lipid Profile and Blood Pressure Assessment in Arterial Hypertension with Chronic Kidney Disease

Early Degeneration of Aortic Bioprosthetic Valves Chemical interactions, prevention and treatment

Assessment of suicidal behavior in dermatology (Review)

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