Evaluation of biochemical, endocrine, and metabolic biomarkers for the early diagnosis of polycystic ovary syndrome among non‐obese Saudi women

Daghestani, Maha H.

doi:10.1002/ijgo.12527

Cited by 32 publications

(22 citation statements)

References 27 publications

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“…They uniformly showed higher insulin resistance, lower SHBG plasma levels, and greater evidence of hyperandrogenism in obese PCOS women compared to their normal weight counterparts [5,8,28]. The results of some the other studies demonstrated that insulin resistance was present in both obese and non-obese women with PCOS [29][30][31]. In this study, although obese PCOS individuals had lower SHBG levels, we did not find a significant difference in insulin resistance and testosterone level between obese and non-obese PCOS patients.…”

Section: Discussionmentioning

confidence: 99%

Insulin resistance and high molecular weight adiponectin in obese and non-obese patients with Polycystic Ovarian Syndrome (PCOS)

2021

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Background Polycystic ovarian syndrome (PCOS) is the most common endocrinopathy among young women. Insulin resistance is a key feature in the pathogenesis of PCOS; also high molecular weight adiponectin is a marker of insulin resistance. The aim of this study was to evaluate the insulin resistance, metabolic and androgenic profiles and high molecular weight adiponectin in obese and non-obese PCOS patients. Methods In this cross-sectional study in outpatient endocrinology clinics of Shiraz University of Medical Sciences, 80 women aged 17–43 years old with PCOS were enrolled. Biochemical and hormonal assay was done on fasting blood sample on the third day of follicular phase. Results The individuals had a mean age of 28.39 ± 6.56 years, mean weight of 65.41 ± 12.59 Kg, mean BMI of 25.5 ± 4.9, and mean waist circumference of 88.0 ± 13.1 cm. Of all individuals 20% had frank insulin resistance with HOMA-IR > 3.8. Although the obese PCOS patients had lower levels of high molecular weight adiponectin (P = 0.03) than the normal weight PCOS individuals, the level of insulin and insulin resistance was not different in them (P = 0.13, 0.13). Patients with classic PCOS phenotype significantly had higher levels of insulin resistance and free androgen index (P < 0.001, 0.001). We found a significant correlation between the insulin level and free androgen index (correlation coefficient: 0.266 and P = 0.018) after adjusting for BMI. Conclusion This cross-sectional study showed a high incidence of insulin resistance in PCOS patients independent of obesity, and determined BMI related lower level of high molecular weight adiponectin in obese PCOS individuals. More detailed studies are warranted for evaluation of insulin resistance and its pathophysiologic role in PCOS.

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Section: Discussionmentioning

confidence: 99%

Insulin resistance and high molecular weight adiponectin in obese and non-obese patients with Polycystic Ovarian Syndrome (PCOS)

2021

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“…Indeed, increased kisspeptin has been reported in several populations of PCOS patients (Albalawi et al 2018, Katulski et al 2018, Umayal et al 2019. Of note, not all populations of women with PCOS exhibit changes in kisspeptin levels (Daghestani 2018, Katulski et al 2018, inferring alterations in the KNDy system may be related to differences in PCOS phenotype or severity. Recent clinical studies also provide support for modulation of the KNDy system as a potential new target for the development of treatment for PCOS.…”

Section: Current Implications and Future Directions From Basic Researmentioning

confidence: 99%

Androgens and ovarian function: translation from basic discovery research to clinical impact

Walters

Paris

Aflatounian

et al. 2019

Journal of Endocrinology

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In the last decade, it has been revealed that androgens play a direct and important role in regulating female reproductive function. Androgens mediate their actions via the androgen receptor (AR), and global and cell-specific Ar-knockout mouse models have confirmed that AR-mediated androgen actions play a role in regulating female fertility and follicle health, development and ovulation. This knowledge, along with the clinical data reporting a beneficial effect of androgens or androgen-modulating agents in augmenting in vitro fertilization (IVF) stimulation in women termed poor responders, has supported the adoption of this concept in many IVF clinics worldwide. On the other hand, substantial evidence from human and animal studies now supports the hypothesis that androgens in excess, acting via the AR, play a key role in the origins of polycystic ovary syndrome (PCOS). The identification of the target sites of these AR actions and the molecular mechanisms involved in underpinning the development of PCOS is essential to provide the knowledge required for the future development of novel, mechanism-based therapies for the treatment of PCOS. This review will summarize the basic scientific discoveries that have enhanced our knowledge of the roles of androgens in female reproductive function, discuss the impact these findings have had in the clinic and how a greater understanding of the role androgens play in female physiology may shape the future development of effective strategies to improve IVF outcomes in poor responders and the amelioration of symptoms in patients with PCOS.

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“…Polycystic ovary syndrome (PCOS) is a reproductive endocrine metabolic disorder characterized by insulin resistance accompanied by persistent ovulation disorder and hyperandrogenemia (Elbohoty Ahmed et al, 2016). Western medicine believes that genetic factors, high luteinizing hormone, glycolipid metabolism disorder (Daghestani, 2018), hyperinsulinemia and insulin resistance (Giandalia), hyperandrogenemia (Li et al, 2018), low degree inflammatory reaction (Jamilian), obesity (Rezvan et al, 2018), abnormal ovarian function and hyperpuberty are the etiology and pathogenesis of PCOS (Leng and Wei, 2018, Zuo and Fu, 2018). PCOS belongs to the category of “late menstruation” and “amenorrhea” in traditional Chinese medicine (TCM).…”

Section: Introductionmentioning

confidence: 99%

Effects of dodder total flavone on polycystic ovary syndrome rat models induced by DHEA combined HCG

Miao

Peng

Zhu

et al. 2019

Saudi Journal of Biological Sciences

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Aims Explore the effects of dodder total flavone on polycystic ovary syndrome (PCOS) rat models induced by dehydroepiandrosterone (DHEA) combined human chorionic gonadotropin (HCG). Methods Except the blank group, the rest of the rats were injected with DHEA 6 mg/100 g on the back of the neck and 1.5 IU HCG each day, for 21 consecutive days. On the 16th day of modeling, vaginal smear was performed to select the model rats, which were randomly divided into model group, dacin-35 group, large, middle and small dose dodder total flavonoids groups, and given the medicine for three weeks. At the end of the last administration, take samples, so as to calculate the ovaries and uterus indexes, measure serum LH/FSH ratio, P, PRL and INS levels, fixed the uterus and pancreas in 10% formalin solution and stained with HE to observe the morphological changes of the organs. And measure the expression of TNF-α and IGF-l proteins in ovaries by immunohistochemistry. Results Compared with the blank group, ovarian and uterine indexes, serum LH/FSH ratio, serum PRL and INS levels, ovary TNF-α and IGF-l protein expression were significantly increased, and significant pathological changes were observed in the uterine and pancreatic tissues in model group ( P < 0.01). While the serum P level decreased significantly ( P < 0.01), Compared with the model group, the ovarian and uterine indexes, serum LH/FSH ratio, serum P, PRL and INS levels, ovary TNF-α protein expression were significantly decreased in large, middle and small dose dodder total flavonoids groups ( P < 0.01); The expression of IGF-1 protein was decreased and uterus pathological changes were improved in different extents ( P < 0.01 or P < 0.05), pancreas pathological changes were improved significantly ( P < 0.01). Conclusion PCOS rat models was successfully replicated. Dodder total flavone can protect PCOS rats induced by DHEA combined HCG by different action pathways.

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Evaluation of biochemical, endocrine, and metabolic biomarkers for the early diagnosis of polycystic ovary syndrome among non‐obese Saudi women

Abstract: Various parameters could potentially be used as biomarkers to assess risk of PCOS, even among symptom-free non-obese women.

Cited by 32 publications

References 27 publications

Insulin resistance and high molecular weight adiponectin in obese and non-obese patients with Polycystic Ovarian Syndrome (PCOS)

Insulin resistance and high molecular weight adiponectin in obese and non-obese patients with Polycystic Ovarian Syndrome (PCOS)

Androgens and ovarian function: translation from basic discovery research to clinical impact

Effects of dodder total flavone on polycystic ovary syndrome rat models induced by DHEA combined HCG

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