Evaluation of biochemical, hematological and histopathological parameters of albino rats treated with Stemona aphylla Craib. extract

Buncharoen, Wararut

doi:10.5897/jmpr12.595

Cited by 12 publications

(14 citation statements)

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“…Thus, hematological parameters including red blood cell count, white blood cell count and packed cell volume value were of diagnostic value [29][30][31][32][33][34] . This study investigated the effect of ethanolic extract of pulverized mango (Mangifera indica) seed kernel (MSKE) on some hematological parameters in normal and monosodium glutamate (MSG)-intoxicated rats, using standard protocols.…”

Section: Discussionmentioning

confidence: 99%

“…Blood functions in the maintenance of physiological homeostasis [28] . Thus, hematological parameters including red blood cell count, white blood cell count and packed cell volume value were of diagnostic value [29][30][31][32][33][34][35] . For instance, red blood cell is involved in the transport of oxygen and carbon dioxide in the body and a reduced red blood cell count implies a reduction in the level of oxygen that would be carried to the tissues as well as the level of carbon dioxide returned to the lungs [36,37,28] .…”

Section: Introductionmentioning

confidence: 99%

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Effect of Ethanolic Extract of Pulverized Mangifera indica (Mango) Seed Kernel on Some Hematological Parameters in Normal and Monosodium Glutamate-Intoxicated Rats

Egbuonu¹

2018

International Journal of Research in Environmental Science

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Ethanolic Extract of Pulverized Mangifera indica (Mango) Seed Kernel on Some Hematological Parameters in Normal and Monosodium Glutamate-Intoxicated Rats

Egbuonu¹

2018

International Journal of Research in Environmental Science

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“…Twenty four (24) male Albino wistar Rats weighing between 225-250 grams were used for the study, they were acclimatized for seven days before any treatment. An average weight adult human of 65kg drinks about 350ml of soft drink, this body weight was used to estimate the concentration in millilitres administered to the rats based on their body weight.…”

Section: Experimental Designmentioning

confidence: 99%

“…The epididymal sperm count was determined with the Neubauer haemocytometer (Deep 1/10 mm, LABART, Munich, Germany) and light microscope at 40× magnifications. Haemoglobin, Packed Cell Volume, White Blood Cells, Red blood cells, Platelets and lymphocyte counts were determined according to the methods of [24]. Electrolytes were determined according to the methods of [25].…”

Section: Biochemical Analysismentioning

confidence: 99%

Reproductive & Biomarker Response of Male Albino Rats (Rattus norvegicus) to a Daily Dose of Soft Drink

Oriakpono

Owolabi

2019

JSRR

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The effect of a daily consumption of soft drink was evaluated using 24 albino male rats divided into two groups viz:control and treatment. The experiment was carried out for four (4) weeks. The treatment (a brand of soft drink) was administered to the test group for three weeks while on the fourth week no treatment was given to the test group. The parameters analysed include; Sperm count, kidney function test, liver test, red blood cell, pack cell volume, haemoglobin, white blood cell, platelets, lymphocytes. The results showed that: The mean serum electrolyte for Na (mmol/l) was low for week 1, 2, 3 and 4 having 142, 140, 133.6 and 141.66 respectively when compared to the average control (147.3) with a significant difference (P<0.05) in week 1 and 4, K (mmol/l) were all lower than the average control (5.4) across the week with no significant difference (P>0.05) but had the least mean value of 4.8 in week 2. Bicarbonate (mmol/l) was also significantly lower (P<0.05) in the treated group when compared to the average control (24.3) with the least mean value in week 4 (18.67) and Cl (mmol/l) had a mean of 93.0 in week 1, 94.67 in week 2, 108.66 in week 3 and 107.67 in week 4 with an average control of 99.33. AST (U/L) mean value was 20.67 in week 1 which increased to 31.67 in week 4 while ALT (U/L) mean value was 10 in week 1 which also increased to 13 in week 4. The mean serum protein (g/dL) reduced from 81.83 in week 1 to 73.24 in week 4. Mean PCV (%) reduced from 33.67 in week 1 to 32.7 in week 4, Hb (g/dL) increased from 11.2 in week 1 to 13.4 in week 4 with a significant difference (P<0.05) when comparing the test with the average control, WBC (X109) increased from a mean 5.26 in week 1 to 11.9 in week 4 with a significant difference (P<0.05), Platelet (X109) mean value was 315 on week 1 and 419 in week 4 with significant difference (P<0.05) in week 3 and 4 when compared with its control, RBC (X1012) increased from a mean of 4.23 in week 1 to 6.90 in week 4 with significant difference (P<0.05). Lymphocyte (X109) mean value for week 1 was 70 and 82.26 in week 4 with significant difference (P<0.05) across the week. While the mean sperm count (X106) reduced significantly (P<0.05) from 425 in week 1 to 400 in week 4 when compared to the average control (566). These findings demonstrate that regular consumption of soft drink had a detrimental effect on the sperm count, liver, kidney and on the haematological parameters.

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“…Increased levels of these parameters are usually due to leakages of the enzymes into blood circulation 41,42 especially when the liver is damaged 43 or its integrity is compromised in certain conditions such as in inflammatory hepatocellular disorders 39 . 44 found that the liver is necrotized in streptozotocininduced diabetic rats.…”

Section: Pathological Studiesmentioning

confidence: 99%

Untitled

2016

IJPSR

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ABSTRACT:The increasing prevalence of diabetes mellitus worldwide is an issue of major socio-economic concern especially in Sub -Saharan Africa. Indigenous medicinal plants are used for the treatment of diabetes mellitus in most developing countries, like Ghana, but remain to be validated. In the present study, the effect of Myrianthus arboreus ethanol stem bark extract (MAB) (100 -400 mg/kg) on glucose levels in streptozotocin (STZ) (45 mg/kg) induced diabetic rats was investigated using glibenclamide 5 mg/kg/day as the positive control. The effects of the extract on body weight, total protein, serum urea, serum creatinine, bilirubin, lipid profile, haematological indices and serum markers for liver function in normal, treated and untreated diabetic rats were also investigated. Induction of the diabetes in Sprague Dawley rats (150-200 g) resulted in increased levels of serum glucose, total cholesterol, triglycerides and LDL-cholesterol but decreased body weight, serum HDL-cholesterol and haemoglobin levels. Administration of the extract at the three dose levels resulted in significant (P<0.001) reduction in the levels of plasma glucose, cholesterol, LDL-cholesterol, triglycerides and serum urea and serum creatinine. Alanine transaminase (ALT) and aspartate transaminase (AST) levels were also significantly (P<0.001) decreased. The significant decrease in body weight, total protein and HDL-cholesterol which were observed in STZ-induced diabetic rats were normalized after 28 days treatment with the extract. At 200 mg/kg/day, MAB recorded significant (P<0.01) reduction in plasma glucose levels compared to glibenclamide (5 m/kg/day). Thus MAB shows significant hypoglycaemic and antihyperlipidaemic activities in STZ-induced diabetic rats justifying its use in traditional medicine. INTRODUCTION:Diabetes is a metabolic disorder characterized by chronic hyperglycaemia and alterations in carbohydrate, protein and lipid metabolism with absolute or relative deficiencies in insulin secretion and/or insulin production 1 .

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Evaluation of biochemical, hematological and histopathological parameters of albino rats treated with Stemona aphylla Craib. extract

Cited by 12 publications

References 16 publications

Effect of Ethanolic Extract of Pulverized Mangifera indica (Mango) Seed Kernel on Some Hematological Parameters in Normal and Monosodium Glutamate-Intoxicated Rats

Effect of Ethanolic Extract of Pulverized Mangifera indica (Mango) Seed Kernel on Some Hematological Parameters in Normal and Monosodium Glutamate-Intoxicated Rats

Reproductive & Biomarker Response of Male Albino Rats (Rattus norvegicus) to a Daily Dose of Soft Drink

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