Evaluation of biofilm formation on novel copper-catalyzed azide-alkyne cycloaddition (CuAAC)-based resins for dental restoratives

Zajdowicz, Sheryl L. W.; Han, Songjun; Baranek, Austin; Bowman, Christopher N.

doi:10.1016/j.dental.2018.01.011

Cited by 17 publications

(12 citation statements)

References 87 publications

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“…The use of copper in resin composite was attempted to reduce the shrinkage stress of the resin matrix. Photo-initiated copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) polymerization demonstrates three times lower shrinkage stress and more antibacterial activities against S. mutans compared to control restorative polymers [ 78 , 79 ].…”

Section: Bioactivity For Clinical Restorative Polymer Materialsmentioning

confidence: 99%

Toward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials

Balhaddad

Kansara

Hidan

et al. 2019

Bioactive Materials

130

111

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Millions of people worldwide suffer from a toothache due to tooth cavity, and often permanent tooth loss. Dental caries, also known as tooth decay, is a biofilm-dependent infectious disease that damages teeth by minerals loss and presents a high incidence of clinical restorative polymeric fillings (tooth colored fillings). Until now, restorative polymeric fillings present no bioactivity. The complexity of oral biofilms contributes to the difficulty in developing effective novel dental materials. Nanotechnology has been explored in the development of bioactive dental materials to reduce or modulate the activities of caries-related bacteria. Nano-structured platforms based on calcium phosphate and metallic particles have advanced to impart an anti-caries potential to restorative materials. The bioactivity of these platforms induces prevention of mineral loss of the hard tooth structure and antibacterial activities against carries-related pathogens. It has been suggested that this bioactivity could minimize the incidence of caries around restorations (CARS) and increase the longevity of such filling materials. The last few years witnessed growing numbers of studies on the preparation evaluations of these novel materials. Herein, the caries disease process and the role of pathogenic caries-related biofilm, the increasing incidence of CARS, and the recent efforts employed for incorporation of bioactive nanoparticles in restorative polymer materials as useful strategies for prevention and management of caries-related-bacteria are discussed. We highlight the status of the most advanced and widely explored interaction of nanoparticle-based platforms and calcium phosphate compounds with an eye toward translating the potential of these approaches to the dental clinical reality.

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Section: Bioactivity For Clinical Restorative Polymer Materialsmentioning

confidence: 99%

Toward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials

Balhaddad

Kansara

Hidan

et al. 2019

Bioactive Materials

130

111

View full text Add to dashboard Cite

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“…Biofilms were formed with a monospecies biofilm model containing a luciferase-expressing Streptococcus mutans (Zajdowicz et al 2018). Briefly, composite discs 7 mm in diameter and 1 mm thickness were sterilized in 70% alcohol containing 0.5% triclosan for 30 min; 3 experiments were conducted with 3 discs for each sample, yielding a total 9 discs per sample.…”

Section: Methodsmentioning

confidence: 99%

Biological and Mechanical Evaluation of Novel Prototype Dental Composites

et al. 2018

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The breakdown of the polymeric component of contemporary composite dental restorative materials compromises their longevity, while leachable compounds from these materials have cellular consequences. Thus, a new generation of composite materials needed to be designed to have a longer service life and ensure that any leachable compounds are not harmful to appropriate cell lines. To accomplish this, we have developed concurrent thiol-ene-based polymerization and allyl sulfide-based addition-fragmentation chain transfer chemistries to afford cross-linked polymeric resins that demonstrate low shrinkage and low shrinkage stress. In the past, the filler used in dental composites mainly consisted of glass, which is biologically inert. In several of our prototype composites, we introduced fluorapatite (FA) crystals, which resemble enamel crystals and are bioactive. These novel prototype composites were benchmarked against similarly filled methacrylate-based bisphenol A diglycidyl ether dimethacrylate / triethylene glycol dimethacrylate (bisGMA/TEGDMA) composite for their cytotoxicity, mechanical properties, biofilm formation, and fluoride release. The leachables at pH 7 from all the composites were nontoxic to dental pulp stem cells. There was a trend toward an increase in total toughness of the glass-only-filled prototype composites as compared with the similarly filled bisGMA/TEGDMA composite. Other mechanical properties of the glass-only-filled prototype composites were comparable to the similarly filled bisGMA/TEGDMA composite. Incorporation of the FA reduced the mechanical properties of the prototype and bisGMA/TEGDMA composite. Biofilm mass and colony-forming units per milliliter were reduced on the glass-only-filled prototype composites as compared with the glass-only-filled bisGMA/TEGDMA composite and were significantly reduced by the addition of FA to all composites. Fluoride release at pH 7 was greatest after 24 h for the bisGMA/TEGDMA glass + FA composite as compared with the similarly filled prototypes, but overall the F release was marginal and not at a concentration to affect bacterial metabolism.

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“…The resins used in dental restoration may favor biofilm development and consequently increase the occurrence of secondary caries [ 111 ]. Therefore, copper has been incorporated in resins used for dental restoration.…”

Section: Copper Surfaces In Health Care Unitsmentioning

confidence: 99%

“…Therefore, copper has been incorporated in resins used for dental restoration. Zajdowicz, et al [ 111 ] synthesized a novel copper-catalyzed azide-alkyne cycloaddition (CuAAC) based resins and composites and found that CuACC reduced biofilm formation, protecting dental restorations for longer periods in comparison to other commonly used resins [ 111 ].…”

Section: Copper Surfaces In Health Care Unitsmentioning

confidence: 99%

Copper Surfaces in Biofilm Control

Gomes

Simões

2020

Nanomaterials

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Biofilms are structures comprising microorganisms associated to surfaces and enclosed by an extracellular polymeric matrix produced by the colonizer cells. These structures protect microorganisms from adverse environmental conditions. Biofilms are typically associated with several negative impacts for health and industries and no effective strategy for their complete control/eradication has been identified so far. The antimicrobial properties of copper are well recognized among the scientific community, which increased their interest for the use of these materials in different applications. In this review the use of different copper materials (copper, copper alloys, nanoparticles and copper-based coatings) in medical settings, industrial equipment and plumbing systems will be discussed considering their potential to prevent and control biofilm formation. Particular attention is given to the mode of action of copper materials. The putative impact of copper materials in the health and/or products quality is reviewed taking into account their main use and the possible effects on the spread of antimicrobial resistance.

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Evaluation of biofilm formation on novel copper-catalyzed azide-alkyne cycloaddition (CuAAC)-based resins for dental restoratives

Abstract: CuAAC-based resins do still allow for the formation of biofilms; however, the statistically significant reduction of growth that was associated with the CuAAC resin may enhance the longevity of restorations that incorporate CuAAC-based materials.

Cited by 17 publications

References 87 publications

Toward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials

Toward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials

Biological and Mechanical Evaluation of Novel Prototype Dental Composites

Copper Surfaces in Biofilm Control

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