Evaluation of Biological Activity of a Diazocine Derivative against
                    Heart Failure Using an Ischemia-Reperfusion Injury Model

Figueroa‐Valverde, Lauro; Marcela, Rosas-Nexticapa; María, López-Ramos; Alvarez-Ramirez, Magdalena; Virginia, Mateu-Armad Maria; Díaz-Cedillo, Francisco; Alejandra, Garcimarrero-Espino; Tomas, Lopez Gutierrez; Melgarejo-Gutiérrez, Montserrat

doi:10.1055/a-1840-3199

Cited by 5 publications

(2 citation statements)

References 48 publications

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“…For several years, different theoretical methods have been used to predict some pharmacokinetics parameters involved in biological activity produced by some drugs such as ADME/PK (Eddershaw et al, 2000), SAAM II (Barrett et al, 1998) and SwissADME (Lauro et al, 2022) and others. Analyzing these data in this research, different pharmacokinetic parameters for carbazole derivatives 11, 17, 20, and 22 were determined using SwissADME.…”

Section: Pharmacokinetic Parametersmentioning

confidence: 99%

Interaction of twenty-two carbazole derivatives with M1-muscarinic receptor using a theoretical model

Figueroa-Valverde,

López-Ramos,

Rosas-Nexticapa

et al. 2024

Braz. J. of Sci.

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Several drugs have been used to treat asthma diseases, such as salmeterol, ipratropium bromide, montelukast, and fluticasone; however, some of these drugs can cause side effects such as hypokalemia, lactic acidosis, and hypotension. Analyzing these data, this study aimed to evaluate the possible interaction of twenty-two carbazole derivatives with the M1-muscrinic receptor to provide a new therapeutic alternative against asthma. The theoretical interaction of carbazole derivatives with M1-muscrinic receptor surface was determined using 5cxv protein, pirenzepine, atropine, AF-150, and PD159714 drugs as theoretical tools in a DockingServer software. The results showed differences in the interaction of carbazole derivatives with the 5cxv protein surface compared with pyranzepine, atropine, AF-150, and PD159714 drugs. Besides, constant inhibition (Ki) for carbazole derivatives 11 and 22 was lower than for pirenzepine and AF-150 drugs. Other data indicate that Ki values for 11 and 22 were higher than atropine and ipratropium bromide. In addition, the Ki values for compounds 17 and 20 were like both atropine and PD150714 drugs. Finally, Ki values for carbazole derivatives 17 and 20 were lower than pyranzepine, ipratropium bromide, and AF-150 reagents. All these data suggest that carbazole derivatives 11, 17, 20, and 22 may act as M1-muscarinic receptor inhibitor agents; this phenomenon could result in the regulation of bronchial tone in asthma disease.

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Section: Pharmacokinetic Parametersmentioning

confidence: 99%

Interaction of twenty-two carbazole derivatives with M1-muscarinic receptor using a theoretical model

Figueroa-Valverde,

López-Ramos,

Rosas-Nexticapa

et al. 2024

Braz. J. of Sci.

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“…[41] Pharmacokinetics parameter Pharmacokinetic parameters were determined using the Swiss ADME software. [42]…”

Section: Ligand-protein Complexmentioning

confidence: 99%

Evaluation of Interaction of Some Quinolone Derivatives on RSK-4 Using a Theoretical Model

Rosas-Nexticapa¹,

Figueroa‐Valverde²,

Alvarez-Ramirez³

et al. 2022

Clin Cancer Investig J

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Prostate cancer is one of the leading causes of death among men worldwide; Some data suggest that ribosomal S6 p90 kinase (RSK 1-4), which belongs to the group of highly conserved Ser/Thr kinases, has been related to an increase in prostate cancer levels. For this reason, the aim of this study was to evaluate the theoretical interaction of some quinolone derivatives (compounds 1-19) with RSK-4 using 6rv2 protein and RSK-14 inhibitor (LJH685) in a docking model. The results showed that some quinolone derivatives (12, 15, 17, and 18) could interact with the 6rv2 protein surface in a different manner than LJH685. This phenomenon could be translated as greater RSK-14 inhibition, resulting in a decrease in prostate cancer levels. Analyzing these data, these quinolone derivatives could be considered good compounds to treat prostate cancer.

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Recent advances in [4 + 4] annulation of conjugated heterodienes with 1,4-dipolar species for the synthesis of eight-membered heterocycles

Wang,

Jin,

Zhou

et al. 2024

Org. Biomol. Chem.

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Evaluation of Biological Activity of a Diazocine Derivative against Heart Failure Using an Ischemia-Reperfusion Injury Model

Cited by 5 publications

References 48 publications

Interaction of twenty-two carbazole derivatives with M1-muscarinic receptor using a theoretical model

Interaction of twenty-two carbazole derivatives with M1-muscarinic receptor using a theoretical model

Evaluation of Interaction of Some Quinolone Derivatives on RSK-4 Using a Theoretical Model

Recent advances in [4 + 4] annulation of conjugated heterodienes with 1,4-dipolar species for the synthesis of eight-membered heterocycles

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