Evaluation of biological effects of three neodymium compounds on silkworm, Bombyx mori

Andoh, Vivian; Guan, Huaiyang; Zhao, Weiguo; Li, Long; Wu, Guohua

doi:10.1016/j.jre.2020.10.010

Cited by 4 publications

(2 citation statements)

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“…The silkworm chrysalis is high in protein and other minerals, making it an excellent source of nutrients for humans and feed additives for animals ( Zhou et al, 2022 ). In addition, due to their important biological role, silkworms have also been used as model organisms for studying environmental toxicology, food safety, drug research, and human disease research ( Xia et al, 2014 ; Qi et al, 2017 ; Andoh et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Multi-omics study and ncRNA regulation of anti-BmNPV in silkworms, Bombyx mori: an update

Fan,

Andoh,

Chen

2023

Front. Microbiol.

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Bombyx mori silkworm is an important economic insect which has a significant contribution to the improvement of the economy. Bombyx mori nucleopolyhedrovirus (BmNPV) is a vitally significant purulent virus that impedes the sustainable and stable development of the silkworm industry, resulting in substantial economic losses. In recent years, with the development of biotechnology, transcriptomics, proteomics, metabolomics, and the related techniques have been used to select BmNPV-resistant genes, proteins, and metabolites. The regulatory networks between viruses and hosts have been gradually clarified with the discovery of ncRNAs, such as miRNA, lncRNA, and circRNA in cells. Thus, this paper aims to highlight the results of current multi-omics and ncRNA studies on BmNPV resistance in the silkworm, providing some references for resistant strategies in the silkworm to BmNPV.

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Section: Introductionmentioning

confidence: 99%

Multi-omics study and ncRNA regulation of anti-BmNPV in silkworms, Bombyx mori: an update

Fan,

Andoh,

Chen

2023

Front. Microbiol.

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“…Bombyx mori silkworm is a well-known and commercially important fully metamorphic insect. It has played important scientific roles in fields such as medicine, genetics, developmental biology, and physiology, among others. , Silkworm has numerous advantages, including low reproduction costs, large offspring, short generation time, and clear genetic background. , Furthermore, there are a plethora of genetic resources on silkworms. For instance, the complete silkworm genome has accelerated its evolution into a modern model organism in life sciences.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of AuCu–Cu₂S Nanocomposites: Implications for Biological Evaluation of the Nanocomposite Effect on Bombyx mori Silkworms and Cell Lines

Andoh,

Shi,

et al. 2023

ACS Biomater. Sci. Eng.

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AuCu–Cu2S nanocomposites are unique materials with exceptional properties that have recently received a lot of interest. However, little is known about their potential toxicity in terrestrial organisms and their subsequent effects on the environment. Therefore, it is essential to develop effective methodologies for evaluating AuCu–Cu2S nanocomposites in biological systems. This study reports the biological evaluation of the AuCu–Cu2S nanocomposite from animal and cell entity levels. The Bombyx mori silkworm was used as a model organism to study the effects of different concentrations of AuCu–Cu2S on silkworm development. Transcriptome analysis was also carried out to examine the genetic modulation exerted by the treatment. Moreover, biocompatibility and cytotoxicity of AuCu–Cu2S were evaluated in human bronchial epithelial cells 16HBE, human lung adenocarcinoma, and the insect Spodoptera frugiperda cell sf9 cell lines. The results showed that although AuCu–Cu2S at ≤400 ppm can prolong the eating habit of silkworms and promote the weight of the cocoon layer, there was an increase in silkworm mortality and a decrease in moth formation at a concentration of ≥800 ppm. The genetic regulation by AuCu–Cu2S treatment showed varying effects in the silkworm, primarily related to functions such as transport and catabolism, metabolism of cofactors and vitamins, xenobiotic biodegradation, amino acid, and carbohydrate. 16HBE, PC-9, and sf9 treated with 300 ppm of AuCu–Cu2S showed viability percentages of 60, 20, and 90%, respectively. Thus, AuCu–Cu2S at low concentrations serves as a safe and biocompatible material for the sf9 cell lines but is lethal to 16HBE and PC-9. This research could aid in understanding the biological effects and biocompatibility of AuCu–Cu2S nanocomposites, particularly in the field of biochemistry; however, the mechanisms involved need further exploration.

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Influence of neodymium on mitochondrial metabolism: a thermokinetic perspective

Xia

Jin

2022

J Therm Anal Calorim

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Evaluation of biological effects of three neodymium compounds on silkworm, Bombyx mori

Cited by 4 publications

References 30 publications

Multi-omics study and ncRNA regulation of anti-BmNPV in silkworms, Bombyx mori: an update

Multi-omics study and ncRNA regulation of anti-BmNPV in silkworms, Bombyx mori: an update

Cytotoxicity of AuCu–Cu₂S Nanocomposites: Implications for Biological Evaluation of the Nanocomposite Effect on Bombyx mori Silkworms and Cell Lines

Influence of neodymium on mitochondrial metabolism: a thermokinetic perspective

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Evaluation of biological effects of three neodymium compounds on silkworm, Bombyx mori

Cited by 4 publications

References 30 publications

Multi-omics study and ncRNA regulation of anti-BmNPV in silkworms, Bombyx mori: an update

Multi-omics study and ncRNA regulation of anti-BmNPV in silkworms, Bombyx mori: an update

Cytotoxicity of AuCu–Cu2S Nanocomposites: Implications for Biological Evaluation of the Nanocomposite Effect on Bombyx mori Silkworms and Cell Lines

Influence of neodymium on mitochondrial metabolism: a thermokinetic perspective

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Cytotoxicity of AuCu–Cu₂S Nanocomposites: Implications for Biological Evaluation of the Nanocomposite Effect on Bombyx mori Silkworms and Cell Lines