Evaluation of biological methods for a future methodological implementation of the Hazard criterion H14 ‘ecotoxic’ in the European waste list (2000/532/EC)

H, Moser; Roembke, Joerg; Donnevert, Gerhild; Becker, Roland

doi:10.1177/0734242x10367844

Cited by 21 publications

(12 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With respect to the FET, the validation studies performed for OECD indicate that coefficients of variation between laboratories were as high as 50% (for exquisitely toxic compounds with LC50s < 100 µg/L) and as low as 4% (LC50s > 100 mg/L) . These coefficients of variation are well within the range of those typical of other aquatic toxicity tests . Limited interlaboratory data are available for the AFT .…”

Section: Discussionsupporting

confidence: 65%

Use of fish embryo toxicity tests for the prediction of acute fish toxicity to chemicals

Belanger

Rawlings

Carr

2013

Enviro Toxic and Chemistry

158

140

View full text Add to dashboard Cite

The fish embryo test (FET) is a potential animal alternative for the acute fish toxicity (AFT) test. A comprehensive validation program assessed 20 different chemicals to understand intra- and interlaboratory variability for the FET. The FET had sufficient reproducibility across a range of potencies and modes of action. In the present study, the suitability of the FET as an alternative model is reviewed by relating FET and AFT. In total, 985 FET studies and 1531 AFT studies were summarized. The authors performed FET-AFT regressions to understand potential relationships based on physical-chemical properties, species choices, duration of exposure, chemical classes, chemical functional uses, and modes of action. The FET-AFT relationships are very robust (slopes near 1.0, intercepts near 0) across 9 orders of magnitude in potency. A recommendation for the predictive regression relationship is based on 96-h FET and AFT data: log FET median lethal concentration (LC50) = (0.989 × log fish LC50) - 0.195; n = 72 chemicals, r = 0.95, p < 0.001, LC50 in mg/L. A similar, not statistically different regression was developed for the entire data set (n = 144 chemicals, unreliable studies deleted). The FET-AFT regressions were robust for major chemical classes with suitably large data sets. Furthermore, regressions were similar to those for large groups of functional chemical categories such as pesticides, surfactants, and industrial organics. Pharmaceutical regressions (n = 8 studies only) were directionally correct. The FET-AFT relationships were not quantitatively different from acute fish-acute fish toxicity relationships with the following species: fathead minnow, rainbow trout, bluegill sunfish, Japanese medaka, and zebrafish. The FET is scientifically supportable as a rational animal alternative model for ecotoxicological testing of acute toxicity of chemicals to fish.

show abstract

Section: Discussionsupporting

confidence: 65%

Use of fish embryo toxicity tests for the prediction of acute fish toxicity to chemicals

Belanger

Rawlings

Carr

2013

Enviro Toxic and Chemistry

158

140

View full text Add to dashboard Cite

show abstract

“…The results of several projects regarding the ecotoxicological characterization of waste performed in France (e.g., Pandard et al 2006) and Germany (Moser et al 2011).…”

Section: The Recommendations Of the Eu Ring Test (Moser Andmentioning

confidence: 99%

“…This proposal is based mainly on: The work carried out in CEN/TC 292/WG 7 (Characterization of Waste—Ecotoxicological Properties). The recommendations of the EU ring test (Moser and Römbke ). The results of several projects regarding the ecotoxicological characterization of waste performed in France (e.g., Pandard et al ) and Germany (Moser et al ). …”

Section: Introductionmentioning

confidence: 98%

“…Consequently, EN 14735 (CEN ) also provides information (particularly limitations) about the application of several aquatic and terrestrial tests on wastes but without proposal of a relevant test battery to assess their ecotoxicity. This standard was used as a basis for a European ring test performed between October 2006 and March 2007, which involved 60 laboratories from 15 countries (Moser and Römbke ; Moser et al ). One outcome of this ring test was a proposal for a battery of 3 tests with waste eluates and 3 with solid wastes, which, slightly modified, has been used in several commercial studies (Römbke et al ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Proposal for a “Harmonized” strategy for the assessment of the HP 14 property

Pandard

Römbke

2013

Integr Environ Assess Manag

View full text Add to dashboard Cite

In Europe, the decision whether waste is hazardous or not is based on 15 properties, among them the HP 14 property ("ecotoxic": waste that presents or may present immediate or delayed risks for 1 or more sectors of the environment). This document describes a strategy for assessing the HP 14 property, based on a combination of 2 approaches: the summation of classified compounds in the waste carried out according to the regulation on Classification, Labeling and Packaging (CLP) of substances and mixtures and the usage of the results of biotests performed on waste eluates and solid wastes. The proposal is based mainly on recommendations of a European ring test carried out in 2007, the work performed in the CEN/TC 292/WG 7 standardization working group, and the results of various research projects regarding the ecotoxicological characterization of waste carried out mainly in France and Germany. Examples are provided showing that, using this approach, a distinction between hazardous and nonhazardous wastes is possible, independent of which type of threshold values is used (currently, both effect concentrations [EC] or lowest ineffective dilutions [LID] values have been used successfully). Furthermore, a battery of tests (3 using waste eluates and 3 using solid waste samples, plus, under certain conditions, a genotoxicity test) is recommended for the ecotoxicological testing of wastes. We propose to consider this combined approach when defining the legal requirements for the ecotoxicological classification of wastes.

show abstract

“…Thus, from an initial examination, it appears that the same biotesting principles are valid for wastes as for chemical substances (Thomas et al 2009). Two types of acute toxicity test batteries (aquatic and soil) are proposed for solid waste and LL in Germany after 2005Germany after -2007 European inter-laboratory comparison ring test (Wilke et al 2008;Moser et al 2011;Pandard, Römbke 2013). Despite the requirement to cover the traditional three trophic levels with biotest species, the aquatic tests battery for waste testing and hazard classification does not include fish (bioluminescent bacteria, algae and crustacean tests are proposed).…”

Section: Introductionmentioning

confidence: 99%

Wastewater and Landfill Leachate Testing: Acute Toxicity Biotest Results Evaluation

Cetkauskaite

Vosylienė

Kazlauskienė

et al. 2016

Journal of Environmental Engineering and Landscape Management

View full text Add to dashboard Cite

This diverse review discusses biotest species and results scoring systems, which were applied to aquatic toxicity assessment of effluents/wastewater (WW) and landfill leachate (LL). European and American aquatic toxicity testing is reviewed. An example of Lithuanian research data on LL biotesting with aquatic organisms of different phylogenetic and ontogenetic levels is presented. Acute toxicity WW and LL is assessed on the basis of (L(E)C50, acute Toxic Units (tua), pt values, and, by applying different simple result scoring systems or toxicity thresholds. The differences in legislation and recommendations for biotest application in WW and LL aquatic toxicity testing are compared. It is concluded that WW and LL lowest acute toxicity data (tua value 0.3) should be considered equally as risk to aquatic environment, and technical management decisions should be made. The universal features of toxicity scoring systems, the problems of inventory of old small landfills and cost effective approach are discussed.

show abstract

Evaluation of biological methods for a future methodological implementation of the Hazard criterion H14 ‘ecotoxic’ in the European waste list (2000/532/EC)

Cited by 21 publications

References 1 publication

Use of fish embryo toxicity tests for the prediction of acute fish toxicity to chemicals

Use of fish embryo toxicity tests for the prediction of acute fish toxicity to chemicals

Proposal for a “Harmonized” strategy for the assessment of the HP 14 property

Wastewater and Landfill Leachate Testing: Acute Toxicity Biotest Results Evaluation

Contact Info

Product

Resources

About