Evaluation of Biomonitoring Data from the CDC National Exposure Report in a Risk Assessment Context: Perspectives across Chemicals

Aylward, Lesa L.; Kirman, Christopher R.; Schoeny, Rita; Portier, Christopher J.; Hays, Sean M.

doi:10.1289/ehp.1205740

Cited by 143 publications

(70 citation statements)

References 32 publications

(23 reference statements)

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“…or POD values from animal experiments (Hays et al, 2007Clewell et al, 2008;Angerer et al, 2011). The HBM data are compared against these reference biomarker concentrations to evaluate health risks and set priorities for risk assessment (Aylward et al, 2013) (i.e., relating internal dose to health effects; Figure 1). Reverse dosimetry on the other hand, aims to estimate the exposure dose that would result in the measured biomarker concentration (i.e., connecting internal dose to exposure; Figure 1).…”

Section: Hbm Data Interpretation Approachesmentioning

confidence: 99%

“…This allows for the direct comparison of the biomarker concentration in a relevant biological matrix (e.g., urine) to BE (derived using appropriate PK data for urine) for a given chemical similar to the HQ approach used in traditional risk assessment. The following equation can be used to calculate the HQ for non-cancer end points (Aylward et al, 2013) [Biomarker] HQ BE =…”

Section: Uses Of Bes In Risk Characterisationmentioning

confidence: 99%

“…Therefore, as a practical measure, use of tools described in previous sections for integrating HBM data in health risk assessment appears logical. Aylward et al (2013) recently utilised BE approach to generate chemical specific HQs for 130 chemicals by comparing the BEs to the corresponding biomonitoring data from CDC (CDC, 2015). In most cases the data from the descriptive statistics published by CDC were used.…”

Section: Integration Of Hbm Data In Human Health Risk Assessmentmentioning

confidence: 99%

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The role of human biological monitoring in health risk assessment

Gurusankar¹,

Yenugadhati

Krishnan

et al. 2017

IJRAM

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Human biological monitoring refers to the measurement of biomarkers in biological specimens. Advances in analytical chemistry together with an increased understanding of the potential toxicity of environmental chemicals have propelled the quest to identify and monitor chemicals and metabolites in human biological specimens. Many biomonitoring programs have provided valuable data on the presence of environmental chemicals in biological matrices. The availability of this large volume of biomonitoring data has increased the need to understand this information with respect to potential human health risks. This review summarises approaches for interpreting biomonitoring data in the context of population health and risk assessment. Moreover, the advantages and limitations of human biomonitoring approaches, major challenges in the interpretation of HBM data and the utility of human biomonitoring data in health risk assessment context are presented. Several knowledge gaps to improve the ability to interpret human biomonitoring data are discussed.

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Section: Hbm Data Interpretation Approachesmentioning

confidence: 99%

Section: Uses Of Bes In Risk Characterisationmentioning

confidence: 99%

Section: Integration Of Hbm Data In Human Health Risk Assessmentmentioning

confidence: 99%

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The role of human biological monitoring in health risk assessment

Gurusankar¹,

Yenugadhati

Krishnan

et al. 2017

IJRAM

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“…It was noted that human biomonitoring levels for several hundred chemicals are already available and extensive work has been published on approaches that enable human biomonitoring data to be interpreted in a risk context (Aylward et al, 2013;Wambaugh et al, 2013). Workshop participants noted that the implementation and use of biomonitoring/exposure (i.e., internal dose) could provide greater understanding and a better means to compare the significance of concentrations responsible for exerting effects in vitro with respect to the internal doses that produce responses in in vivo studies.…”

Section: Utilization Of Exposure Informationmentioning

confidence: 99%

Lessons learned, challenges, and opportunities: The U.S. Endocrine Disruptor Screening Program

Juberg¹,

Borghoff

Becker

et al. 2014

ALTEX

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“…Application: Soring methods provide a simple risk ranking method that is often implemented to easily characterize chemical hazards for subsequent categorization into particular groups (Aylward et al, 2013;Bietlot and Kolakowski, 2012;Bu et al, 2013;Greim and Reuter, 2001;Taxell et al, 2013;van Asselt et al, 2013). It provides a screening tool that is often implemented as a pre-analysis to understand the potential risk before more in-depth risk assessments are later utilized.…”

mentioning

confidence: 99%

Critical review of methodology and application of risk ranking for prioritisation of food and feed related issues, on the basis of the size of anticipated health impact

Fels‐Klerx

Asselt

Raley³

et al. 2015

EFS3

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Document VersionPublisher's PDF, also known as Version of record Link back to DTU Orbit Citation (APA): van der Fels-Klerx, H. J., van Asselt, E. D., Raley, M., Poulsen, M., Korsgaard, H. B., Bredsdorff, L., ... Frewer, L. (2015). Critical review of methodology and application of risk ranking for prioritisation of food and feed related issues, on the basis of the size of anticipated health impact. Europen Food Safety Authority. (EFSA Supporting Publications; No. 710E, Vol. 12(1) ABSTRACTThis study aimed to critically review methodologies for ranking of risks related to feed/food safety and nutritional hazards, on the basis of their anticipated human health impact. An extensive systematic literature review was performed to identify and characterize the available methodologies for risk ranking in the fields of feed and food safety and nutritional hazards, as well as the socio-economic field. Risk ranking methods from the environmental field were studied as well to determine whether approaches used in this field could also be applied for ranking human health risks related to feed and food safety and nutritional hazards. The review used a predefined search protocol. It covered the bibliographic databases Scopus, CAB Abstracts, Web of Sciences, and PubMed over the period 1993-2013. All references obtained were stored into an Endnote database and evaluated for their relevance. All references deemed to be relevant were studied in-depth so as to characterize the risk ranking method described. Characteristics of each method were stored in an Excel database. The methods for risk ranking were then grouped into method categories, which were described in general. These groups included: risk assessment, comparative risk assessment, risk ratio method, scoring method, cost of illness, DALY/QALY, willingness to pay, multi criteria decision analysis, risk matrix, flow charts/decision trees and expert judgment methods. Based on the characteristics of the individual methods and the method categories, an overarching framework was developed for selection of the appropriate method(s) that could be used for risk ranking of feed and food related hazards, on the basis of human health impact. This framework has the format of a decision tool, with which -given the characteristics of the risk ranking question at hand -the most appropriate method(s) can be selected. Application of this overall framework to several case studies showed it can be a useful tool for risk managers/assessors to select the most suitable method for risk ranking of feed/food and diet related hazards, on the basis of expected human health impact. © RIKILT, 2015 DISCLAIMERThe present document has been produced and adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the context of a contract between the European Food Safety Authority and the author(s), awarded following a tender procedure. The present document is published complying with the transparency principle to which the Authority is subject. It...

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Evaluation of Biomonitoring Data from the CDC National Exposure Report in a Risk Assessment Context: Perspectives across Chemicals

Cited by 143 publications

References 32 publications

The role of human biological monitoring in health risk assessment

The role of human biological monitoring in health risk assessment

Lessons learned, challenges, and opportunities: The U.S. Endocrine Disruptor Screening Program

Critical review of methodology and application of risk ranking for prioritisation of food and feed related issues, on the basis of the size of anticipated health impact

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