Evaluation of biosynthesis parameters, stability and biological activities of silver nanoparticles synthesized by <i>Cornus Officinalis</i> extract under 365 nm UV radiation

Wang, Yinghui; Wei, Simin; Wang, Kang; Wang, Zhe; Duan, Jinwei; Cui, Lin; Zheng, Huayu; Wang, Ying; Wang, Shanshan

doi:10.1039/d0ra04482b

Cited by 22 publications

(17 citation statements)

References 44 publications

(62 reference statements)

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“…By using the GraphPad Prism 8.0 soware package, the IC 50 values of AgNPs against these three cancer cell lines were further determined to be 13.07, 19.67 and 26.18 mg mL À1 , respectively. These values were comparable to the AgNPs synthesized using traditional medicine with anticancer effect, such as Iresine herbstii (51 mg mL À1 for Hela), 40 Sesbania grandiora (20 mg mL À1 for MCF-7), 24 Cornus officinalis (20.68 and 69.72 mg mL À1 for HCT116 and HepG2) 22 and Sea buckthorn (8.77, 4.61, 14.59, 16.05 and 27.98 mg mL À1 for HCT116, SW620, HepG2, MCF-7 and HeLa), 21 indicating that the AgNPs synthesized using RBM extract could be a potential candidate for anticancer drugs.…”

Section: Anticancer Activities Of Biosynthesized Agnpssupporting

confidence: 64%

“…To date, several plant including Coconut inflorescence sap, 13 Citrus reticulata peels, 15 grape seed, 16 Arbutus unedo , 17 Nelumbo nucifera , 18,19 Fumaria parviflora , 20 and Coffea arabica 10 have been employed for biosynthesizing AgNPs with different physicochemical and biological properties. Especially, since it is rich of bioactive ingredients, traditional Chinese herbal medicines (CHMs) like Sea buckthorn , 21 Cornus officinalis , 22 Iresine herbstii , 23 Sesbania grandiflora 24 and Alpinia katsumadai 25 have also attracted enormous attentions for biosynthesizing medicinal AgNPs.…”

Section: Introductionmentioning

confidence: 99%

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A novel green synthesis of silver nanoparticles by the residues of Chinese herbal medicine and their biological activities

et al. 2021

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Section: Anticancer Activities Of Biosynthesized Agnpssupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

A novel green synthesis of silver nanoparticles by the residues of Chinese herbal medicine and their biological activities

et al. 2021

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“…Moreover, the obtained results are compatible with those recorded by He et al [81], who reported that the IC 50 of the HepG2 cell line treated with Ag-NPs synthesized by aqueous fruit extract of Chinese herbal Cornus officinalis for 48 h was 21.46 µg mL −1 . On the other hand, data recorded by Wang et al [82] showed that the IC 50 of Ag-NPs fabricated by extract of Cornus officinalis under UV-radiation was 69.72 mg mL −1 for the HepG2 cancerous cell line. There is variation between the IC 50 values recorded by He et al [81] and Wang et al [82], although the Ag-NPs synthesized using the same aqueous plant extract could be attributed to the bioactive metabolites involved in the plant extract used for reducing and capping Ag-NPs, particles sizes, or biosynthesis environmental conditions [82].…”

Section: In Vitro Cytotoxicitymentioning

confidence: 93%

Antimicrobial and In Vitro Cytotoxic Efficacy of Biogenic Silver Nanoparticles (Ag-NPs) Fabricated by Callus Extract of Solanum incanum L.

et al. 2021

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The in vitro callus induction of Solanum incanum L. was executed on MS medium supplemented with different concentrations of auxin and cytokinin utilizing petioles and explants of leaves. The highest significant fresh weights from petioles and leaf explants were 4.68 and 5.13 g/jar for the medium supplemented with1.0 mg L−1 BA and 1.0 mg L−1 2,4-D. The callus extract of the leaves was used for the green synthesis of silver nanoparticles (Ag-NPs). Analytical methods used for Ag-NPs characterization were UV-vis spectroscopy, Fourier Transform Infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and Transmission Electron Microscopy (TEM). Spherical, crystallographic Ag-NPs with sizes ranging from 15 to 60nm were successfully formed. The FT-IR spectra exhibited the role of the metabolites involved in callus extract in reducing and capping Ag-NPs. The biological activities of Ag-NPs were dose-dependent. The MIC value for Staphylococcus aureus, Bacillus subtilis, and Escherichia coli was 12.5 µg mL−1, while it was 6.25 µg mL−1 for Klebsiella pneumoniae, Pseudomonas aeruginosa, and Candida albicans. The highest inhibition of phytopathogenic fungi Alternaria alternata, Fusarium oxysporum, Aspergillus niger, and Pythium ultimum was 76.3 ± 3.7, 88.9 ± 4.1, 67.8 ± 2.1, and 76.4 ± 1.0%, respectively at 200 µg mL−1. Moreover, green synthesized Ag-NPs showed cytotoxic efficacy against cancerous cell lines HepG2, MCF-7 and normal Vero cell line with IC50 values of 21.76 ± 0.56, 50.19 ± 1.71, and 129.9 ± 0.94 µg mL−1, respectively.

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“…The IC 50 values of AgNPs against HCT116, HepG2, and HeLa cancer cell lines were determined by fitting the curve of the cell viability using the GraphPad Prism 8.0 software package, and the values were 9.0, 14.5, and 31.5 μg·mL –1 , respectively. The AgNPs synthesized by the Mentha pulegium extract herein displayed a higher anticancer activity than the AgNPs synthesized by Hadi Faranak using Iranian Mentha pulegium (∼100 μg·mL –1 for Hela and MCF-7), 46 and other traditional medicines with an anticancer effect, such as Iresine herbstii ( 60 ) (51 μg·mL –1 for Hela) and Cornus officinalis ( 31 ) (20.68 and 69.72 μg·mL –1 for HCT116 and HepG2, respectively). Additionally, these values were also comparable to those of Sea buckthorn ( 30 ) (8.77, 14.59, and 27.98 μg·mL –1 for HCT116, HepG2, and HeLa, respectively), indicating that the AgNPs biosynthesized using Mentha pulegium extract could be acted as candidate for anticancer drugs.…”

Section: Resultsmentioning

confidence: 89%

“… 22 , 27 Thus, traditional Chinese medicines have attracted considerable attention from analysts due to medicinal components in them. 28 − 34 To date, numerous Chinese herbal medicines such as Sea buckthorn , 30 , 35 Zizyphus mauritiana , 36 Nelumbo nucifera , 37 , 38 and Cornus officinalis ( 31 , 33 , 39 , 40 ) have been employed for the synthesis of bioactive AgNPs.…”

Section: Introductionmentioning

confidence: 99%

Green Fabrication of Bioactive Silver Nanoparticles Using Mentha pulegium Extract under Alkaline: An Enhanced Anticancer Activity

Wang

Wei

2021

ACS Omega

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Fabrication of silver nanoparticles (AgNPs) using Chinese herbal medicine is popular as the bioactive components included in them would generate potential synergistic effect with the metal nanoparticles. The leaf of Mentha pulegium , whose extract contains a range of phytochemicals and exhibits a wide spectrum of bioactivities, is used as Chinese herbal medicine after drying naturally. Thus, the green synthesis of AgNPs using Mentha pulegium has aroused interests from analysts. However, the biosynthesis of AgNPs under alkaline conditions and the biological activities remain elusive, where alkaline conditions may influence the physicochemical properties and the biological activities of biosynthesized AgNPs. In this study, we were stimulated to fabricate bioactive AgNPs using Mentha pulegium extract under alkaline conditions, accompanied by a systematic evaluation on the effect of biosynthesis parameters on the formation, average size, and polydispersity of AgNPs. Our results showed that alkaline conditions could accelerate the formation of AgNPs with a small average size but at a disadvantage to the polydispersity. Additionally, the as-prepared AgNPs had a hexagonal structure and spherical shape with an average size of 15.7 ± 0.1 nm, existing in the monodispersed form and revealing a high degree of stability. The AgNPs exhibited potent antioxidant and significant inhibitory activity for both bacterial and cancer cell lines. The MIC values of AgNPs for Staphylococcus aureus and Escherichia coli were both 50.0 μg·mL –1 , and the IC 50 values for HCT116, HepG2, and HeLa cells were 9.0, 14.5, and 31.5 μg·mL –1 , respectively. The AgNPs biosynthesized using M. pulegium under alkaline conditions, which had a smaller size and more surface loads, are entirely different with those synthesized under acidic conditions, and the anticancer activity increased significantly. The internalization of AgNPs inside these five cells displayed a variant trend with variable AgNPs concentrations, suggesting the different mechanism of cell death. For two pathogens, HCT116 and HepG2 cancer cell lines, both cell wall and intracellular damage may be responsible for the cell death. However, for Hela cell line the cell death may be rooted in oxidative stress or intracellular penetration. These results confirmed that the AgNPs biosynthesized from M. pulegium extract under alkaline conditions would act as better anticancer agents in biomedicine.

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Evaluation of biosynthesis parameters, stability and biological activities of silver nanoparticles synthesized by Cornus Officinalis extract under 365 nm UV radiation

Abstract: We present herein a systematically evaluation of the biosynthesis parameters on the green synthesis of AgNPs by utilizing Cornus officinalis extract under 365 nm UV radiation.

Cited by 22 publications

References 44 publications

A novel green synthesis of silver nanoparticles by the residues of Chinese herbal medicine and their biological activities

A novel green synthesis of silver nanoparticles by the residues of Chinese herbal medicine and their biological activities

Antimicrobial and In Vitro Cytotoxic Efficacy of Biogenic Silver Nanoparticles (Ag-NPs) Fabricated by Callus Extract of Solanum incanum L.

Green Fabrication of Bioactive Silver Nanoparticles Using Mentha pulegium Extract under Alkaline: An Enhanced Anticancer Activity

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