Evaluation of blood donors questionnaire in a developing country: The case of Gabon

Rerambiah, Léonard Kouegnigan; Biyoghe, A.S.; Bengone, Calixte; Siawaya, Joël Fleury Djoba

doi:10.1016/j.tracli.2014.03.003

Cited by 5 publications

(6 citation statements)

References 15 publications

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“…Africa, but those that we did find reported that DHQs are inefficient as they were developed without assessment of local HIV risk factors Abbreviations: BRH, Bafoussam Regional Hospital; YUTH, Yaounde University Teaching Hospital; YCH, Yaounde. [6,7]. This study also confirmed the poor performance of RQ used in Cameroon.…”

Section: Discussionsupporting

confidence: 76%

“…The low sensitivity of DHQ increases the risk of collecting blood from at‐risk donors, while low specificity would result in the exclusion of too many safe donors and adversely impact the blood supply. Our literature review revealed only a few assessments of DHQ in sub‐Saharan Africa, but those that we did find reported that DHQs are inefficient as they were developed without assessment of local HIV risk factors [6, 7]. This study also confirmed the poor performance of RQ used in Cameroon.…”

Section: Discussionsupporting

confidence: 71%

“…The identification and exclusion of donors with high-risk behaviours leads to a significant yet poorly quantified reduction in the risk of infections for the blood recipients and ensures donor safety as well. However, medical selection is inappropriately conducted in several African blood services, and the donor health questionnaire (DHQ) used for it is frequently inefficient [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Implementation of an Africa‐specific donor health questionnaire for human immunodeficiency virus risk screening

et al. 2022

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Background and Objectives: We had previously developed an Africa-specific donor health questionnaire (ASDHQ) based on local risk factors and designed a scoring scheme. This study assessed the performance of a new donor health questionnaire by comparing the human immunodeficiency virus (HIV) status in accepted versus deferred donors by ASDHQ and comparing the rate of risk deferrals with historical data. Materials and Methods: Data were collected during a cross-sectional study conducted over 15 months at three referral-hospital-based blood services in Cameroon. ASDHQ was administered to blood donors aged 18-65 years in the same screening conditions as the routine questionnaire. The main outcomes of the study were ASDHQ sensitivity and specificity with regard to HIV laboratory testing as well as donor deferral rates for each of the routine screening algorithms and for ASDHQ.Results: Overall, 71/11,120 (0.6%) were confirmed as HIV positive. The mean ASDHQ score was 95.80 AE 4.4 in HIV-negative donors and 94.80 AE 4.4 in HIV-positive donors (p = 0.05). The optimal cut-off provided by the receiver operating characteristic (ROC) curve for the best performance of ASDHQ was 95.04. Using this optimal cut-off, the ASDHQ sensitivity and specificity were 57% and 53%, respectively (area under curve = 0.58 [0.51, 0.64], p = 0.028).

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Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

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Implementation of an Africa‐specific donor health questionnaire for human immunodeficiency virus risk screening

et al. 2022

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“…Using a DHQ reduces the risk of transmission of blood-borne infectious agents by transfusion. A study showed a significant reduction in Gabonese seropositive donors (hepatitis B, hepatitis C, and syphilis) who completed a DHQ ( 11 ), although this encouraging finding was not observed in all studies ( 12 ), probably partly because of differences in the prevalence of pathogens.…”

Section: Discussionmentioning

confidence: 99%

An Original Approach to Evaluating the Quality of Blood Donor Selection: Checking Donor Questionnaires and Analyzing Donor Deferral Rate

Gillet¹,

Neijens²

2018

Front. Med.

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Blood donor selection is a cornerstone for blood transfusion safety, designed to safeguard the health of both donors and recipients. In the Service du Sang, Belgian Red Cross, French and German-speaking part of Belgium (SFS), health professionals (HPs) are allowed to interview donors on their own after formal qualification. This qualification is afterward evaluated by means of two complementary quality indicators: monitoring of donor health questionnaires (DHQs) and analysis of donor deferral rate. The study aims to evaluate the degree to which both quality indicators may be useful and appropriate tools to evaluate the quality of blood donor selection. An analysis performed on 2016 data showed that noncompliance detected by means of DHQ monitoring seems to be more frequent in HPs who conduct a low number of interviews compared to all HPs as a group (5.67 vs. 3.23%; p < 0.001). Deferral rates are also higher in HPs with a lower activity compared to HPs who interview more donors (14.80 vs. 13.00%, p < 0.001). Furthermore, statistically differences are observed between the type of blood donation venue in terms of the global deferral rate (for instance fixed site vs. schools: 11.9 vs. 19.5%; p < 0.001), and specific reasons for deferral (such as sexual risk behavior and travel in at-risk areas, the differences being highly significant between each category of blood donation venue; p < 0.001). Providing the HPs with feedback on these findings was an opportunity to draw their attention to some aspects of the selection process in order to improve it.

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“…Syphilis seroprevalence declined from 8.4% in 2004 to 2.4% in 2016. Previous studies in Gabon in the 1980s showed higher seroprevalence of syphilis from 11.4 to 13.3% [9, 10] compared to seroprevalence of 4.6 and 2.1% obtained in the 2000s [8, 13]. Comparing data collected in 2004 and 2016 is a limitation of the study but data from 2005 to 2015 was not available in full and could not be used reliably.…”

Section: Discussionmentioning

confidence: 90%

Decline in the seroprevalence of syphilis markers among first-time blood donors in Libreville (Gabon) between 2004 and 2016

et al. 2019

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BackgroundVery few studies have been conducted on the seroprevalence of syphilis in Gabon. According to the World Health Organization, the average seroprevalence of syphilis has declined from 5.5 to 1.1% in Central Africa. The aim of this study was to test the hypothesis that syphilis decreased in Gabon between 2004 and 2016 and to identify factors involved in this pattern by testing a large sample of first-time blood donors in the capital Libreville.MethodsThe detection of Treponema pallidum was done using a Rapid Plasma Reagin test (RPR) and confirmed by an ELISA test using the Biorad Syphilis Total Antibody EIA II kit or BioMerieux Trepanostika TP recombinant. Assays were performed by dedicated technicians according to manufacturers’ recommendations and following the laboratory standard operating procedures. Test results were manually transferred into the laboratory Excel files and hand-written in the laboratory logbook for syphilis testing. Logistic regression was used to assess the impact of sociodemographic characteristics on syphilis marker seroprevalence in both univariate and multivariable analysis. Odds ratios (OR) and 95% confidence intervals were calculated.ResultsThe seroprevalence of syphilis markers was 8.4% (95% CI = 7.9–8.9) in 2004 and 2.4% (95% CI = 2.1–2.7) in 2016. The difference was significant [OR = 3.78; 95% CI (3.26–4.38); P < 0.001]. The decrease in syphilis seroprevalence was significant in both women and men and in each age group in univariate analysis. In multivariable analysis, controlling for all sociodemographic factors, the decrease in syphilis seroprevalence from 2004 to 2016 remained significant (OR = 3.29; 95% CI = 2.88–3.88, P < 0.001). The seroprevalence of syphilis decreased significantly in men compared to women and young donors compared to donors aged ≥36 years.ConclusionsThis study shows a significant decline in syphilis seroprevalence in first-time blood donors in Libreville, Gabon. Government actions, including multiple HIV prevention activities, are a likely part of this decline.

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Evaluation of blood donors questionnaire in a developing country: The case of Gabon

Cited by 5 publications

References 15 publications

Implementation of an Africa‐specific donor health questionnaire for human immunodeficiency virus risk screening

Implementation of an Africa‐specific donor health questionnaire for human immunodeficiency virus risk screening

An Original Approach to Evaluating the Quality of Blood Donor Selection: Checking Donor Questionnaires and Analyzing Donor Deferral Rate

Decline in the seroprevalence of syphilis markers among first-time blood donors in Libreville (Gabon) between 2004 and 2016

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