Evaluation of bone regenerative capacity in rats claverial bone defect using platelet rich fibrin with and without beta tri calcium phosphate bone graft material

Abdullah, Walid Ahmed

doi:10.1016/j.sdentj.2015.09.003

Cited by 24 publications

(24 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Animals were divided into three main groups; control group and two experimental groups. Following the surgical protocol used by Abdullah WA (8) , all surgeries were done under general anesthesia, an approximately 1.5 cm incision was done to expose the cranial bone. Then two noncritical size bone defects (3 mm diameter) were created one in each parietal side of the rat calvarial bone.…”

Section: Methodsmentioning

confidence: 99%

Transmission Electron Microscopic Examination of the Healing Power Effect of Milled Teeth Versus Beta- Tri Calcium Phosphate Grafted in Calvarial Bone Defect in Rats.

Hassan

Elsaied

Ghali³

2020

Dental Science Updates

View full text Add to dashboard Cite

Aim: to evaluate the effect of milled teeth versus beta tricalcium phosphate bone graft material on new bone formation at the cell level using transmission electron microscope Materials and methods: Forty-five adult male albino rats, were divided into three main groups (n=15); control and two experimental groups. Under general anesthesia, 1.5 cm incision was done exposing the cranial bone. Then two noncritical size bone defects were created one in each parital sides of the rat calvarial bone. In Group I (control group): the bilateral calvarial bony defects were left to heal spontaneously. In Group II the bilateral calvarial bony defects completely filled with β-TCP. In Group III: the bilateral calvarial bony defects completely filled with tooth ash. Five rats from each group were sacrificed after 7, 15, and 30 days postoperatively. Results: tooth ash group: showed more new bone formation. Different types of cells appeared more active: multiple lymphocytes, fibroblast, osteoprogenitor cells, osteoblasts. Multinucleated osteoclasts with prominent vacuolated cytoplasm and ruffled border in Howship's lacunae were clearly seen. At day 30, disappearing of the tooth ash and infiltration of different types of cells; osteoprogenitor cells, bone lining cells, and osteoblasts while β-TCP particles were still seen in the sections. Conclusions: Bone activity, formation and maturity were ahead in tooth ash filled calvarial bony defects. Tooth ash had a role in the stimulation of osteoblastic activity in matrix formation and its mineralization.

show abstract

Section: Methodsmentioning

confidence: 99%

Transmission Electron Microscopic Examination of the Healing Power Effect of Milled Teeth Versus Beta- Tri Calcium Phosphate Grafted in Calvarial Bone Defect in Rats.

Hassan

Elsaied

Ghali³

2020

Dental Science Updates

View full text Add to dashboard Cite

show abstract

“…Beneficial effects of PRF have also been reported in cases of patellar tendinopathy [110], partial ulnar collateral ligament tears [111], elbow ulnar collateral ligament insufficiency in high-level throwers [112], and in the treatment of meniscal lesions [113]. The promise of PRF is not limited to muscle injuries, and recent studies reveal its ability to promote bone healing and regeneration when applied with several grafting materials in animal and human calvarial defects [114,115,116]. Thus, iPRF offers hope to aid both bone and muscle regeneration following serious trauma-induced injuries.…”

Section: Methods—literature Reviewmentioning

confidence: 99%

Platelet-Rich Fibrin and Its Emerging Therapeutic Benefits for Musculoskeletal Injury Treatment

et al. 2019

View full text Add to dashboard Cite

New therapies that accelerate musculoskeletal tissue recovery are highly desirable. Platelet-rich fibrin (PRF) is a leukocyte- and platelet-rich fibrin biomaterial that acts as a binding site for both platelets and growth factors. Through increasing the local concentration of growth factors at specific tissues, PRF promotes tissue regeneration. PRF has been frequently used in combination with bone graft materials to reduce healing times and promote bone regeneration during maxillofacial surgery. However, its benefits during muscle repair and recovery are less well-documented. Here, we perform a narrative review on PRF therapies and muscle injuries to ascertain its beneficial effects. We reviewed the factors that contribute to the biological activity of PRF and the published pre-clinical and clinical evidence to support its emerging use in musculoskeletal therapy. We include in vitro studies, in vivo animal studies and clinical articles highlighting both the success and failures of PRF treatment. PRF can promote the healing process when used in a range of orthopaedic and sports-related injuries. These include cartilage repair, rotator cuff surgery and anterior cruciate ligament surgery. However, conflicting data for these benefits have been reported, most likely due to inconsistencies in both PRF preparation protocols and dosing regimens. Despite this, the literature generally supports the use of PRF as a beneficial adjuvant for a range of chronic muscle, tendon, bone or other soft tissue injuries. Further clinical trials to confirm these benefits require consistency in PRF preparation and the classification of a successful clinical outcome to fully harness its potential.

show abstract

“…Of note, platelet concentrates may help overcome these issues. The bone regeneration capacity of PRF mixed with β-tricalcium phosphate is higher than that of PRF alone, although the difference is only significant in the initial two weeks post-surgery ( 59 ). Furthermore, there are discrepancies regarding the effects of PRF combined with different grafts on bone formation and maturation ( 60 ).…”

Section: Strategies To Enhance the Properties Of Platelet Concentrmentioning

confidence: 99%

Novel applications of platelet concentrates in tissue regeneration (Review)

et al. 2021

View full text Add to dashboard Cite

Numerous studies have explored the suitability of biocompatible materials in regenerative medicine. Platelet concentrates are derived from centrifuged blood and are named according to their biological characteristics, such as platelet-rich plasma, platelet-rich fibrin and concentrated growth factor. Platelet concentrates have gained considerable attention in soft and hard tissue engineering. Indeed, multiple components of autologous platelet concentrates, such as growth factors, fibrin matrix and platelets, serve essential roles in wound healing. Current studies are focused on cutting-edge strategies to meet the requirements for tissue restoration by improving the properties of autologous platelet concentrates. In the present review, applications of platelet concentrates for tissue engineering are discussed, presenting a selection of recent advances and novel protocols. In addition, several aspects of these strategies, such as the advantages of lyophilized platelet concentrates and the combination of platelet concentrates with biomaterials, stem cells or drugs are discussed. The present review aims to summarize novel strategies using platelet concentrates to improve the outcomes of wound healing.

show abstract

Evaluation of bone regenerative capacity in rats claverial bone defect using platelet rich fibrin with and without beta tri calcium phosphate bone graft material

Cited by 24 publications

References 32 publications

Transmission Electron Microscopic Examination of the Healing Power Effect of Milled Teeth Versus Beta- Tri Calcium Phosphate Grafted in Calvarial Bone Defect in Rats.

Transmission Electron Microscopic Examination of the Healing Power Effect of Milled Teeth Versus Beta- Tri Calcium Phosphate Grafted in Calvarial Bone Defect in Rats.

Platelet-Rich Fibrin and Its Emerging Therapeutic Benefits for Musculoskeletal Injury Treatment

Novel applications of platelet concentrates in tissue regeneration (Review)

Contact Info

Product

Resources

About