Evaluation of broiler performance and carcass yields when fed diets containing maize grain from transgenic product DP-2Ø2216-6

McNaughton, James; Roberts, M.; Smith, Brenda; Carlson, Anne; Mathesius, Carey A.; Roper, Jason M.; Zimmermann, C.; Walker, Carl; Huang, Emily; Herman, Rod A.

doi:10.1016/j.japr.2020.05.004

Cited by 6 publications

(10 citation statements)

References 26 publications

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“…All housing conditions and animal management practices were as previously described. 6 Broilers were fed their respective dietary treatments from the day of hatching (day 0) to 42 days of age. Determination of body weights and feed intakes were made every 7 days to calculate cumulative (days 0 to 42) body weight gain, feed intake, and mortality-corrected feed conversion ratio.…”

Section: Methodsmentioning

confidence: 99%

“…All surviving birds selected for carcass data collection were humanely euthanized by exsanguination with complete severing of the spinal column on day 42 with carcass, individual carcass-parts (breast, thigh, wing, leg, and abdominal fat), and organ (kidney, liver) yielded data collected from seven broilers per pen. Data summary and statistical analysis were as previously described 6 with endpoints for broiler fed DP23211 diet statistically compared with endpoints of those fed the Control diet. As there were no significant treatment x sex interactions observed for any trait, the combined-sex analysis was interpreted for all measures.…”

Section: Methodsmentioning

confidence: 99%

“…Animal feeding studies have consistently confirmed the safety of GM crops shown to be compositionally equivalent to their non-GM counterparts, calling into question the necessity and ethics, of continuing to perform these feeding studies when there are no substantial compositional changes within the crop’s edible fraction (grain and/or forage) of interest. 5 , 6 However, it is critical to continue to publish the results of animal feeding studies with GM crops to supplement the overwhelming empirical evidence such that regulatory bodies feel comfortable modifying regulations to align with the scientific evidence.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the safety and nutritional equivalency of maize grain with genetically modified event DP-Ø23211-2

et al. 2021

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Feeding studies were conducted with rats and broiler chickens to assess the safety and nutrition of maize grain containing event DP-Ø23211-2 (DP23211), a newly developed trait-pyramid product for corn rootworm management. Diets containing 50% ground maize grain from DP23211, non-transgenic control, or non-transgenic reference hybrids (P0928, P0993, and P1105) were fed to Crl:CD®(SD) rats for 90 days. Ross 708 broilers were fed phase diets containing up to 67% maize grain from each source for 42 days. Body weight, gain, and feed conversion were determined for comparisons between animals fed DP23211 and control diets in each study. Additional measures included clinical and neurobehavioral evaluations, ophthalmology, clinical pathology, organ weights, and gross and microscopic pathology for rats, and carcass parts and select organ yields for broilers. Reference groups were included to determine if any observed significant differences between DP23211 and control groups were likely due to natural variation. No diet-related effects on mortality or evaluation measures were observed between animal fed diets produced with DP23211 maize grain and animal fed diets produced with control maize grain. These studies show that maize grain containing event DP-Ø23211-2 is as safe and nutritious as non-transgenic maize grains when fed in nutritionally adequate diets. The results are consistent with previously published studies, providing further demonstration of the absence of hazards from edible-fraction consumption of genetically modified plants.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of the safety and nutritional equivalency of maize grain with genetically modified event DP-Ø23211-2

et al. 2021

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“…However, to satisfy global data requirements, the required animal feeding studies were conducted to investigate the nutritional equivalence and safety of DP202216 maize grain Table 2. A 42-day broiler study was conducted with male and female Ross 708 broiler chickens. 53 No statistical differences (P-value > 0.05) were observed between broilers consuming diets produced with DP202216 test maize grain and broilers consuming diets produced with control maize grain for 42 days (for standard measurement endpoints including weight gain, mortality, mortalityadjusted feed efficiency, organ yields, or carcass parts yields). 53 Based upon the results from this study, diets produced with DP202216 maize grain were determined to be nutritionally equivalent to diets produced with control maize grain.…”

Section: Assessment Of Potential Unintended Effects On Nutrition Usinmentioning

confidence: 97%

Hypothesis-based food, feed, and environmental safety assessment of GM crops: A case study using maize event DP-202216-6

et al. 2021

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Event DP-2Ø2216-6 (referred to as DP202216 maize) was genetically modified to increase and extend the expression of the introduced zmm28 gene relative to endogenous zmm28 gene expression, resulting in plants with enhanced grain yield potential. The zmm28 gene expresses the ZMM28 protein, a MADS-box transcription factor. The safety assessment of DP202216 maize included an assessment of the potential hazard of the ZMM28 protein, as well as an assessment of potential unintended effects of the genetic insertion on agronomics, composition, and nutrition. The history of safe use (HOSU) of the ZMM28 protein was evaluated and a bioinformatics approach was used to compare the deduced amino acid sequence of the ZMM28 protein to databases of known allergens and toxins. Based on HOSU and the bioinformatics assessment, the ZMM28 protein was determined to be unlikely to be either allergenic or toxic to humans. The composition of DP202216 maize forage and grain was comparable to non-modified forage and grain, with no unintended effects on nutrition or food and feed safety. Additionally, feeding studies with broiler chickens and rats demonstrated a low likelihood of unintentional alterations in nutrition and low potential for adverse effects. Furthermore, the agronomics observed for DP202216 maize and nonmodified maize were comparable, indicating that the likelihood of increased weediness or invasiveness of DP202216 maize in the environment is low. This comprehensive review serves as a reference for regulatory agencies and decision-makers in countries where authorization of DP202216 maize will be pursued, and for others interested in food, feed, and environmental safety.

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“…Their role may be increasing with the pressure to reduce the use of antibiotics in animal production (Oliveira et al, 2020). Natural feed additives (Cieslak et al, 2013) will play a role in animal production along with functional ingredients (Maqsood et al, 2020), probiotics (Al-Shawi et al, 2020), essential oils (Curabay et al, 2020), feed enzymes (Rossow et al, 2020), genetically modified grains (McNaughton et al, 2020), and many other functional ingredients. All will need to be evaluated in current production systems across multiple animal species.…”

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confidence: 99%

Grand Challenge in Animal Nutrition

Harmon

2020

Front. Anim. Sci.

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Evaluation of broiler performance and carcass yields when fed diets containing maize grain from transgenic product DP-2Ø2216-6

Cited by 6 publications

References 26 publications

Evaluation of the safety and nutritional equivalency of maize grain with genetically modified event DP-Ø23211-2

Evaluation of the safety and nutritional equivalency of maize grain with genetically modified event DP-Ø23211-2

Hypothesis-based food, feed, and environmental safety assessment of GM crops: A case study using maize event DP-202216-6

Grand Challenge in Animal Nutrition

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