Evaluation of carboxymethylated plectranthus edulis starch as a suspending agent in metronidazole benzoate suspension formulations

Brhane, Yonas

doi:10.1371/journal.pone.0228547

Cited by 7 publications

(5 citation statements)

References 36 publications

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“…The redispersibilities of CMPS were found to be better than NaCMC. The author pointed out that all suspen sions resulted in a release of greater than 85% of drug within 1 h. All suspension formulations were found to be stable (Brhane, 2020). The author con cluded carboxymethylated P. edulis starch can be used as alternative suspending agent.…”

Section: Starch Physicochemical Propertiesmentioning

confidence: 99%

“…In other recent study, carboxymethylated P. edulis starch was evaluated as a suspending agent in metro nidazole benzoate suspensions by comparing with sodium carboxymethyl cellulose (NaCMC) (Brhane, 2020). The author reported viscosities of the formu lations prepared with carboxymethylated P. edulis starch were significantly lower than that of NaCMC.…”

Section: Starch Physicochemical Propertiesmentioning

confidence: 99%

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Prospects for improvement of Plectranthus edulis (Vatke) Agnew: A high potential food security crop

Feyissa

2021

Adv. Hort. Sci.

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Plectranthus edulis (Vatke) Agnew is a tuber crop originated and cultivated in Ethiopia for food and medicinal uses. It has higher quality nutrient composition than other tuber crops. The cultivation of P. edulis is under threat because of introduction of exotic species, land use change, habitat destruction, population pressure, selection of only few local varieties by farmers and climate change. Although P. edulis is a high potential food security crop, there is no any improved variety as there has been very little research on the crop. This lack of research attention including absence of improved varieties and lack of conservation strategy may lead to significant genetic erosion of this crop. Previous studies of P. edulis include documentation of indigenous knowledge, analysis of nutritional composition and the use of its starch in drug formulation, traditional cultivation practices, micropropagation, in vitro regeneration, and morphological and molecular genetic diversity. However, more extensive research in all aspects is required for its improvement, use and conservation. Therefore, it is imperative to review the research results of this crop for the research community. This article reviewed research findings of this crop and presents it in a comprehensive way so that the readers will get ample information and can refer original research findings for the details.

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Section: Starch Physicochemical Propertiesmentioning

confidence: 99%

Section: Starch Physicochemical Propertiesmentioning

confidence: 99%

Prospects for improvement of Plectranthus edulis (Vatke) Agnew: A high potential food security crop

Feyissa

2021

Adv. Hort. Sci.

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“…The suspension could have been a deflocculated one. Redispersion is an important aspect of the pharmaceutical quality of a dilute suspension since they tend to settle on standing (storage) 27,28 . Dose uniformity is dependent on the homogeneity of the suspension during administration; therefore, a suspension with low redispersion number will be desirable.…”

Section: Figure 1: Representative Plot Of Sedimentation Volume Agains...mentioning

confidence: 99%

Evaluation of Basella alba L. Mucilage as a Suspending Agent in Metronidazole Suspension

Alayo

Bamiro

Esther

et al. 2022

JJPS

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In the quest for natural biodegradable, non-toxic polymers for use as excipients in pharmaceutical formulations, mucilage of Basella alba L (BAM) stem was isolated and evaluated as a suspending agent in metronidazole suspensions at different concentrations (0.5% - 2% w/v) in comparison to tragacanth (TCG) and gelatin gums (GLT). The micromeritic properties of the mucilage powder were determined and the metronidazole suspension was characterized using flow rate, redispersion number, sedimentation volume, viscosity and pH. The degree of flocculation was also determined. BAM powder has good flow property with minimal swelling. The order of flow rate of metronidazole suspension was BAM=TCG>GLT while sedimentation volume ranking was TCG>BAM>GLT. There was no significant difference (p>0.05) in the redispersion number of BAM and TCG formulations. The viscosities of formulations containing BAM and TCG at concentrations of 0.5%-1.0% w/v were the same. The pH of the suspensions ranged from 5 to 8. The degree of flocculation was in the order GLT>BAM>TCG. From our findings, BAM can be used as an alternative suspending agent in suspension formulation.

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“…The base of the measuring cylinder was held with the left palm while the mouth was covered and held with the right palm. The cylinder was inverted in a clockwise direction through 180˚ [22], and then returned anticlockwise to its former position within a time of 20 ± 5 sec. This was taken as one shake.…”

Section: Redispersibility Determinationmentioning

confidence: 99%

In vitro quality assessment of ten brands of metronidazole benzoate suspensions marketed in Warri, Nigeria

Nwachukwu

Ubieko

2020

GSC Biol. and Pharm. Sci.

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Therapeutic failure as a result of high incidence of fake, adulterated, counterfeit and substandard drugs usage is a major concern to health practitioners, drug regulatory agencies, drug consumers and the general public in Nigeria. The objective of this study was to carry out in vitro quality assessment/evaluation of ten (10) different brands of metronidazole benzoate suspensions that are marketed in Warri, Nigeria. Metronidazole benzoate suspensions (10 brands) were purchased from some pharmacies in Warri, Nigeria. They were checked for the label information on both the secondary and primary packages, physical examination of the primary containers for tampering/breakage of seal on cap, organoleptic properties, pH, sedimentation volume, flow rate, viscosity, redispersibility and content of active ingredient/assay using standard methods. Results obtained showed that the suspensions had the necessary information on their labels, the containers were not tampered with in order to access or change their content. All the brands tested showed good results for color variation, pH, viscosity, flow rate, sedimentation, and redispersibility. All the brands met with their label claims of metronidazole benzoate content based on British Pharmacopoeia specification [95 - 105 %] except one brand (MET-A), that failed. Generally, nine of the brands representing 90 % met with their label claim and can be considered fit for distribution and consumption.

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Evaluation of carboxymethylated plectranthus edulis starch as a suspending agent in metronidazole benzoate suspension formulations

Cited by 7 publications

References 36 publications

Prospects for improvement of Plectranthus edulis (Vatke) Agnew: A high potential food security crop

Prospects for improvement of Plectranthus edulis (Vatke) Agnew: A high potential food security crop

Evaluation of Basella alba L. Mucilage as a Suspending Agent in Metronidazole Suspension

In vitro quality assessment of ten brands of metronidazole benzoate suspensions marketed in Warri, Nigeria

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