Evaluation of CD4+CD25+FOXP3+ regulatory T cells function in patients with common variable immunodeficiency

Arandi, Nargess; Mirshafiey, Abbas; Jeddi-Tehrani, Mahmood; Abolhassani, Hassan; Sadeghi, Behzad; Moeini, Babak; Shaghaghi, Mohammadreza; Aghamohammadi, Asghar

doi:10.1016/j.cellimm.2013.03.003

Cited by 49 publications

(38 citation statements)

References 27 publications

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“…Moreover, IL-10 was produced at markedly lower amounts by Treg cells in CVID patients. No differences were seen in the TGF-β concentration between patients and the control group [36]. Genre et al [66] and Holm et al [67] reported a decreased level of IL-10 in CVID.…”

Section: Regulatory T-cell Defectsmentioning

confidence: 89%

“…Phenotypic and functional defects of CD4 + T cells in CVID patients have been reported during the last decade [35][36][37]. These abnormalities include increased activated CD4 + T-cell counts and decreased total, naive, and memory CD4 + T-cell counts (Table 2), along with functional impairment, such as reduced proliferative capacity and failure in cytokine production [37,38].…”

Section: Cd4 + T-cell Defects In Cvidmentioning

confidence: 99%

“…Several studies have demonstrated that Treg counts are reduced in CVID patients [61][62][63]. Moreover, residual Treg cells appear to have reduced suppressive capacity [36] with downregulation of FoxP3 protein and diminished expression of inhibitory markers such as CTLA-4 and GITR [64]. In contrast, Kutukculer et al [14] recently suggested that Treg cells do not play an important role in the pathogenesis of CVID.…”

Section: Regulatory T-cell Defectsmentioning

confidence: 99%

“…Furthermore, the downregulation of FoxP3, granzyme A, and pStat5 was significantly correlated with the degree of Treg dysfunction in CVID [63]. In a study performed at our research center, Arandi et al [36] used the Treg suppression assay to prove that the suppressive function of Treg cells was impaired. Moreover, IL-10 was produced at markedly lower amounts by Treg cells in CVID patients.…”

Section: Regulatory T-cell Defectsmentioning

confidence: 99%

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T-Cell Abnormalities in Common Variable Immunodeficiency

Azizi

Rezaei

Kiaee

et al. 2016

J Investig Allergol Clin Immunol

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Common variable immunodeficiency (CVID) is the most common clinical primary immunodeficiency. It is characterized by a defect in B-cell differentiation to plasma and memory B cells. Moreover, numerous T-cell abnormalities have been reported and include decreased T-cell count and proliferative response, increased T-cell activation and apoptosis, and abnormalities in cytokine production. The aims of this review are to describe phenotypic and functional defects in T cells in CVID patients and to review the literature with respect to the effects of immunoglobulin replacement on the T-cell component in CVID patients. Key words: Common variable immunodeficiency. T cell. Helper T cells. Regulatory T cells. ResumenLa inmunodeficiencia común variable (CVID) es la inmunodeficiencia primaria más frecuente. Se caracteriza por un defecto en la diferenciación de linfocitos B hacia células plasmáticas y linfocitos B memoria. Se han descrito numerosas alteraciones en los linfocitos T de estos pacientes, tales como disminución en el número de linfocitos T y en sus respuestas proliferativas, aumento en la activación de células T y en la apoptosis, así como alteraciones en la producción de citokinas. El objetivo de esta revisión es describir las alteraciones funcionales y fenotípicas de los linfocitos T en los pacientes con CVID y revisar la bibliografía en relación a los efectos que la administración de inmunoglobulinas produce en los linfocitos T de los pacientes con CVID. Palabras clave: Inmunodeficiencia común variable. Células T. Células T helper. Células T reguladoras.

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Section: Regulatory T-cell Defectsmentioning

confidence: 89%

Section: Cd4 + T-cell Defects In Cvidmentioning

confidence: 99%

Section: Regulatory T-cell Defectsmentioning

confidence: 99%

Section: Regulatory T-cell Defectsmentioning

confidence: 99%

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T-Cell Abnormalities in Common Variable Immunodeficiency

Azizi

Rezaei

Kiaee

et al. 2016

J Investig Allergol Clin Immunol

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“…There is evidence to show that defects in the development, function, and number of Tregs are among the main factors that account for autoimmune complications in patients with PADs [38,39]. On the other hand, the high similarity of Treg defect features with organ-specific autoimmune diseases confirms an obligatory role of these cells in maintaining tolerance to epithelial and endocrine tissues [40,41].…”

Section: Mechanisms Of Tolerance and Autoimmunity In Padsmentioning

confidence: 99%

Autoimmunity in Primary Antibody Deficiencies

Azizi¹,

Ahmadi²,

Abolhassani³

et al. 2016

Int Arch Allergy Immunol

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Primary antibody deficiencies (PADs) are the most common inherited primary immunodeficiencies in humans, characterized by hypogammaglobulinemia, an inability to produce specific antibodies, and recurrent infections mainly caused by encapsulated bacteria. However, it has been shown that inflammatory disorders, granulomatous lesions, lymphoproliferative diseases, cancer, and autoimmunity are associated with the various types of PAD. Both systemic and organ-specific autoimmune diseases could be attributed to B-cell defects in PAD patients. Immune thrombocytopenic purpura and autoimmune hemolytic anemia are the most common autoimmune disorders in this group of patients. The aim of this review is to describe the proposed mechanisms for autoimmunity and to review the literature with respect to the reported autoimmune disorders in each type of PAD.

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