Evaluation of CdZnTe spectrometer performance in measuring energy spectra during interventional radiology procedure

Chai, Lu; Chen, Lian; Yang, Cuiping; Zhou, Dong‐Dong; Qu, Weiwei; Zhang, Gaolong; Hei, Daqian; Xu, Shouping; Chen, Xinjian

doi:10.1007/s41365-019-0661-8

Cited by 4 publications

(6 citation statements)

References 19 publications

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“…Also, temperature uncertainty of irradiated PAA-APF nanogels defined as × (2 stability)/ 3 was 0.1%. 10 To evaluate the fading effect, I 515 was read after irradiation for several weeks (Figure 3b). The specimens were stored in darkness at room temperature.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Temporal uncertainty of irradiated PAA-APF nanogels defined as × (2 stability)/ 3 was 1.9%. 10 Taken together, we found that the temperature and storage period showed negligible negative effects on the performance of our dosimeters, which potentially facilitate their clinical applications.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Importantly, FL signals can be easily obtained without any postionizing radiation waiting time, which facilitates their application in practical radiotherapy. The PAA-APF nanogel batch uniformity was estimated by measuring different gel batches under 1 Gy and statically analyzing the data by the eq where n is the number of PAA-APF dosimeters and σ is the standard deviations, and it showed an uncertainty of 10%.…”

Section: Resultsmentioning

confidence: 99%

“…The maximum decay was 94.7 ± 5.1% at 65 °C compared to FL 25 , which enables accurate radiation dosimetry over a wide temperature range. Also, temperature uncertainty of irradiated PAA-APF nanogels defined as was 0.1% . To evaluate the fading effect, I 515 was read after irradiation for several weeks (Figure b).…”

Section: Resultsmentioning

confidence: 99%

“…Excessive or insufficient doses of X-rays potentially threaten patients, so monitoring the delivered doses is of vital significance. To reach this goal, a variety of sensors (or dosimeters) have been developed to measure the dose of ionizing radiation. − For instance, thermoluminescent dosimeters are widely used for personal dosimetry. The pretreatment and readout procedure of thermoluminescent dosimeters are complicated and time-consuming .…”

mentioning

confidence: 99%

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Fluorescent Nanogel Sensors for X-ray Dosimetry

Jiang

Nie

et al. 2021

ACS Sens.

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X-ray dosimeters are of significance for detecting the levels of ionizing radiation exposure in cells and phantoms; thus, they can further optimize X-ray radiotherapy in the clinic. In this paper, we designed a polyacrylamide-based nanogel sensor that is capable of measuring X-ray doses. The dosimeters were prepared by anchoring an X-ray-responsive probe (aminophenyl fluorescein, APF) to poly(acrylamide-co-N-(3-aminopropyl) methyl acrylamide) nanogels. The premise behind the dose measurement is the transition of APF to fluorescence in the presence of hydroxyl radicals that are caused by the radiolysis of water molecules under X-rays. Therefore, the dose of X-rays can be readily detected by measuring the fluorescence intensity of the resultant nanogel immediately after irradiation using fluorescence spectroscopy principles. Using an RS2000 Xray biological irradiator, our dosimeters showed good linearity responsivity at X-ray doses ranging from 0 to 15 Gy, with a limit of detection (LOD) of 0.5 Gy. Additionally, the signals showed temperature stability (25−65 °C), durability (5 weeks), and dose−rate (1.177 and 6 Gy/min) and energy independence (160 kVp and 6 MV). As a proof-of-concept, we used our sensors to fluorescently detect X-ray doses in A549 tumor cells and 3D-printed eye phantoms. The results showed that our dosimeters were able to accurately predict doses similar to those used by treatment plan systems.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%