Evaluation of cellular antioxidant components of honeys using UPLC-MS/MS and HPLC-FLD based on the quantitative composition-activity relationship

Shen, Shun-Qing; Wang, Jingbo; Chen, Xi; Liu, Tingting; Zhuo, Qin; Zhang, Shuang‐Qing

doi:10.1016/j.foodchem.2019.04.105

Cited by 43 publications

(29 citation statements)

References 33 publications

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“…Furthermore, our very recent study, although on blossom honeys, showed that overall antibacterial activity of honeys correlated with the level of total H 2 O 2 as well as with total polyphenol content . Dark honeys such as honeydew, buckwheat, chestnut or eucalyptus honeys appeared to be the richest in polyphenols and consequently showed higher biological activities …”

Section: Discussionmentioning

confidence: 75%

Antibacterial potential of Swiss honeys and characterisation of their bee‐derived bioactive compounds

et al. 2019

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BACKGROUND: Antibacterial activity of honey is not only crucial characteristic in selection of honey for medical usage but also an important honey quality marker. The aim of the study was to characterise the antibacterial potential of 29 honey samples representing the main types of multi-floral blossom and honeydew honeys produced in Switzerland. Antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa was expressed as a minimum inhibitory and bactericidal concentrations (MIC and MBC). Furthermore, the content of bee-derived glucose oxidase (GOX) and its enzymatic product, H 2 O 2 , were also evaluated.RESULTS: All honey samples successfully met basic defined criteria (moisture and hydroxymethylfurfural (HMF)) tested in this study. Honeydew honeys were the most effective honey samples and generated the highest levels of H 2 O 2 . A strong significant correlation was found between the overall antibacterial activity and the level of H 2 O 2 among all honey samples. Interestingly, the content of GOX in honey samples did not correlate with their antibacterial activity as well as H 2 O 2 production capacity. A weak antibacterial activity was determined in five floral honeys, most likely due to increased enzymatic activity of pollen-derived catalase.CONCLUSION: This study showed that antibacterial effect of Swiss honey samples is associated mainly with H 2 O 2 .

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Section: Discussionmentioning

confidence: 75%

Antibacterial potential of Swiss honeys and characterisation of their bee‐derived bioactive compounds

et al. 2019

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“…Due to their health-promoting effects, these plants were used in folk medicine in the form of herbal supplements, for the treatment of diabetes, inflammatory diseases, allergies and cancer. Furthermore, sakuranetin is a phytochemical abundantly present in many plant extracts [36,37] and the honey of different floral and geographic origins [38] well known for their various biological activities. According to the latest reports, the content of sakuranetin in linden honey was the highest among seven types of honey (Table 2) [38].…”

Section: Sources Of Sakuranetinmentioning

confidence: 99%

A Review on Sources and Pharmacological Aspects of Sakuranetin

Stompor

2020

Nutrients

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Sakuranetin belongs to the group of methoxylated flavanones. It is widely distributed in Polyomnia fruticosa and rice, where it acts as a phytoalexin. Other natural sources of this compound are, among others, grass trees, shrubs, flowering plants, cheery, and some herbal drugs, where it has been found in the form of glycosides (mainly sakuranin). Sakuranetin has antiproliferative activity against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320). Moreover, sakuranetin shows antiviral activity towards human rhinovirus 3 and influenza B virus and was reported to have antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties. The aim of this review is to present the current status of knowledge of pro-health properties of sakuranetin.

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“…Taking compound 7 as an example, the deprotonated molecular ion m/z 447.15176 was detected in the spectrum. were phenylpropanoids, which were considered to be isoferulic acid, ferulic acid, p-coumaric acid, and (E)-4-Methoxycinnamic acid [30,31]. There were four flavonoid glycosides and five flavonoids, which were identified as quercetin-3β-d-glucoside (45) [34], cirsimarin (49) [35], astragalin (50) [36], kaempferol-7-O-glucoside (56) [37], desmethylxanthohumol (59) [38], isorhamnetin (61) [39], naringenin chalcone (63) [40], equol (65) [41], and galangin (82) [42], respectively.…”

Section: Phenolic Acid Derivativesmentioning

confidence: 99%

Rapid Characterizaiton of Chemical Constituents of the Tubers of Gymnadenia conopsea by UPLC–Orbitrap–MS/MS Analysis

et al. 2020

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Gymnadenia conopsea R. Br. is a traditional Tibetan medicinal plant that grows at altitudes above 3000 m, which is used to treat neurasthenia, asthma, coughs, and chronic hepatitis. However, a comprehensive configuration of the chemical profile of this plant has not been reported because of the complexity of its chemical constituents. In this study, a rapid and precise method based on ultra-high performance liquid chromatography (UPLC) combined with an Orbitrap mass spectrometer (UPLC–Orbitrap–MS/MS) was established in both positive- and negative-ion modes to rapidly identify various chemical components in the tubers of G. conopsea for the first time. Finally, a total of 91 compounds, including 17 succinic acid ester glycosides, 9 stilbenes, 6 phenanthrenes, 19 alkaloids, 11 terpenoids and steroids, 20 phenolic acid derivatives, and 9 others, were identified in the tubers of G. conopsea based on the accurate mass within 3 ppm error. Furthermore, many alkaloids, phenolic acid derivates, and terpenes were reported from G. conopsea for the first time. This rapid method provides an important scientific basis for further study on the cultivation, clinical application, and functional food of G. conopsea.

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Evaluation of cellular antioxidant components of honeys using UPLC-MS/MS and HPLC-FLD based on the quantitative composition-activity relationship

Cited by 43 publications

References 33 publications

Antibacterial potential of Swiss honeys and characterisation of their bee‐derived bioactive compounds

Antibacterial potential of Swiss honeys and characterisation of their bee‐derived bioactive compounds

A Review on Sources and Pharmacological Aspects of Sakuranetin

Rapid Characterizaiton of Chemical Constituents of the Tubers of Gymnadenia conopsea by UPLC–Orbitrap–MS/MS Analysis

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