2020
DOI: 10.1016/j.ijid.2020.01.023
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Evaluation of cerebrospinal fluid CXCL13 concentrations and lymphocyte subsets in tick-borne encephalitis

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Cited by 17 publications
(13 citation statements)
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“…In addition, several biomarkers for TBE have been identified in serum or CSF samples (reviewed in [15]), which may be useful for potential application in the diagnosis, prognosis, monitoring, or treatment of TBE [15]. For example, high-mobility group box 1 or chemokine (C-X-C motif) ligand (CXCL) 13 can be used to distinguish TBE meningitis from meningoencephalitis [15][16][17]. The levels of λ-free light chains, matrix metalloproteinase-9, or CXCL1 can be used as indicators of blood-brain barrier disruption [15,18,19].…”
Section: Introductionmentioning
confidence: 99%
“…In addition, several biomarkers for TBE have been identified in serum or CSF samples (reviewed in [15]), which may be useful for potential application in the diagnosis, prognosis, monitoring, or treatment of TBE [15]. For example, high-mobility group box 1 or chemokine (C-X-C motif) ligand (CXCL) 13 can be used to distinguish TBE meningitis from meningoencephalitis [15][16][17]. The levels of λ-free light chains, matrix metalloproteinase-9, or CXCL1 can be used as indicators of blood-brain barrier disruption [15,18,19].…”
Section: Introductionmentioning
confidence: 99%
“…It has been revealed that CXCL13 demonstrates a lower but still high performance in discriminating between meningitis and meningoencephalitis in comparison to the total lymphocyte and total cell count in the CFS. Furthermore, correlations between the lymphocyte count, total protein, and albumin concentration in the CSF and CXCL13 suggest its involvement in the movement of lymphocytes expressing CXCR5 from serum to the cerebrospinal fluid [ 32 ].…”
Section: Resultsmentioning
confidence: 99%
“…Though comparably modest in numbers, the knowledge gain obtainable through flow cytometry of CSF cells is increasingly recognized and applied in order to investigate other neurological diseases. These diseases include paraneoplastic disorders [ 30 , 79 , 83 ], cerebral vasculitis [ 84 ], non-paraneoplastic cerebellar ataxia [ 85 ], paediatric onset neuromyelitis optica [ 86 ] and anti-NMDAR-encephalitis [ 87 ], neurosarcoidosis [ 60 ], stroke [ 88 ], dementia [ 89 ], temporal lobe epilepsy [ 90 ], Susac syndrome [ 62 ], inflammatory neuropathies [ 60 ], tick-borne encephalitis [ 91 ], and HTLV-1-associated myelopathy/tropical spastic paraparesis [ 61 ], amongst others.…”
Section: Perspectives For Translation Into Csf Diagnosticsmentioning
confidence: 99%