Evaluation of cervical lymph node metastasis of 1400 patients with cancer of the larynx

Tomik, Jerzy; Składzień, Jacek; Modrzejewski, M

doi:10.1016/s0385-8146(00)00116-4

Cited by 51 publications

(31 citation statements)

References 28 publications

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“…We and other authors have shown that overall advanced nodal disease leads to regional and distant metastatic disease 14–16 . However, data from the more abundant advanced supraglottic and pyriform cancers cannot be transposed to that of the glottic tumors 14,17–19 .…”

Section: Discussionmentioning

confidence: 94%

Management of Stage IV Glottic Carcinoma: Therapeutic Outcomes

et al. 2004

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The five treatment modalities had statistically similar survival, recurrence, and complication rates. The overall 5-year DSS for patients with stage IV glottic carcinoma was 45%, and the OS was 39%. The cumulative disease-specific survival (CDSS) was 0.4770 with a mean survival of 10.1 years and a median survival of 3.9 years. Patients younger than age 55 years had better survival (DSS) than patients 56 years of age or older (P =.0002). Patients with early T stage had better survival than patients with more advanced T stage (P =.04). Tumor recurrence at the primary site (P =.0001) and in the neck (P =.014) and distant metastasis (P =.0001) had a deleterious effect on survival. Tumor recurrence was not related to treatment modality. Patients with clear margins of resection had a statistically significant improved survival (DSS and CDSS) compared with patients with close or involved margins (P =.0001). Post-treatment quality of life was not significantly related to treatment modality. Patients whose N0 neck was treated with observation and appropriate treatment for subsequent neck disease had statistically similar survival compared with patients whose N0 neck was treated prophylactically at the time of treatment of the primary. A minimum of 7 years of follow-up is recommended for early identification of recurrent disease, second primary tumors, and distant metastasis. None of the standard treatment modalities currently employed has a statistical advantage regarding survival, recurrence, complications, or quality of life.

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Section: Discussionmentioning

confidence: 94%

Management of Stage IV Glottic Carcinoma: Therapeutic Outcomes

et al. 2004

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“…MRND and RND emerged as the preferred therapeutic procedures for clinically positive neck nodes, regardless of the clinical staging of N [7]. Tomik et al [14] analyzed the clinicopathological data of 1,400 patients with laryngeal carcinoma and cN0 or cN+ neck status submitted to 2,270 neck dissections of whom 2,147 underwent MRND and 123 RND, followed by RT in 639 (45.6%) cases. They found 460 (32.9%) pN+, which were unilateral in 75.6% of cases.…”

Section: Discussionmentioning

confidence: 99%

“…NRs occurred in 4 SND and 2 RND. With the exception of Tomik et al [14], most of the studies compare data of neck dissections in patients affected by H&N cancers of different primary site. This is the first study whose focus was confined to patients affected by laryngeal cancer with clinical evidence of cervical metastases treated by individualized therapeutic neck dissection.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Therapeutic Selective Neck Dissection in Laryngeal Cancer

Allegra

Franco²,

Domanico³

et al. 2014

ORL

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Background: The aim of this study was to evaluate the effectiveness of selective neck dissection (SND) in patients with laryngeal cancer and clinically positive cervical nodes. Subjects and Methods: A retrospective review of the clinical records of 58 consecutive untreated patients affected by laryngeal carcinoma and submitted to surgical treatment was performed. Results: Twenty-six (44.8%) patients received monolateral neck dissection and 32 (55.2%) bilateral neck dissection. A total of 90 hemineck dissections were performed. Histopathological examination revealed that 25 of the 58 patients had negative nodes (pN0) and 33 had positive nodes (pN+). Extracapsular spread was found in 12 of the 33 pN+ patients. Twenty-eight of the 58 (48.2%) patients were submitted to adjuvant radiotherapy. Six of the 58 patients submitted to neck dissection had neck recurrence (rate of 10.3%). The only independent prognostic factor for neck recurrence was extracapsular spread. For the 58 patients, the 5-year overall survival was 50% and the disease-specific survival 68.9%. The 5-year disease-specific survival was 76% for pN0 patients and 63.6% for pN+ patients. Conclusions: SND can represent a therapeutic procedure because it has shown oncological results comparable to those of comprehensive neck dissection, especially when SND is combined with adjuvant radiotherapy.

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“…Nonetheless the importance of evaluating the pre‐laryngeal and pre‐cricoid region for nodal metastasis have been emphasized from the 1960s, especially when operating on patients with transglottic and subglottic cancers, or dissecting the thyroid isthmus and pyramidal lobe 7, 8. Data from studies examining the incidence and significance of DN positivity in laryngeal and hypopharyngeal cancers are summarized in Table I 2, 3, 7, 9–18. Nine of these studies have examined an unselected group of patients undergoing laryngectomy for laryngeal and hypopharyngeal tumors 2, 3, 7, 9–14.…”

Section: The Delphian Node In Laryngeal and Hypopharyngeal Cancersmentioning

confidence: 99%

Delphian node metastasis in head and neck cancers—Oracle or myth?

Iyer

Shaha

Ferlito

et al. 2010

Journal of Surgical Oncology

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Delphian node (DN) refers to the pre-laryngeal or pre-cricoid nodal tissue often identified during laryngeal or thyroid surgery. The original nomenclature is based on the assumption that metastasis to this node was predictive of aggressive disease and poor outcome for patients. In this article, we review the existing literature on the topic to determine the significance of DN metastasis in laryngeal, hypopharyngeal and thyroid cancers.

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Evaluation of cervical lymph node metastasis of 1400 patients with cancer of the larynx

Cited by 51 publications

References 28 publications

Management of Stage IV Glottic Carcinoma: Therapeutic Outcomes

Management of Stage IV Glottic Carcinoma: Therapeutic Outcomes

Effectiveness of Therapeutic Selective Neck Dissection in Laryngeal Cancer

Delphian node metastasis in head and neck cancers—Oracle or myth?

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