Evaluation of changes in cardiac biomarker concentrations and enzyme activities in serum after short- and long-duration transcutaneous cardiac pacing in dogs

Abstract

Results indicated that application of TCP for > 1 hour in dogs may cause myocardial and skeletal muscular injuries. Serum concentrations of creatine kinase-MB fraction and cardiac troponin I and activities of aspartate transaminase, creatine kinase, and lactate dehydrogenase should be more carefully monitored after TCP of > 1 hour's duration to evaluate potential myocardial damages.

Incidence of elevation of cardiac troponin I prior to and following routine general anaesthesia in dogs

“…Structural cTnI release leads to a second peak 2–4 days after injury (Wolfe Barry et al. 2008; Lee et al. 2009).…”

Cardiac troponin-I concentrations in dogs with bradyarrhythmias before and after artificial pacing

“…The electrical discharge generated by pacing may also induce cardiac injury. Lee et al 31 measured cTnI concentrations in 10 dogs following 3 h of pacing and reported modest elevations of both cTnI and skeletal muscle creatine kinase. However, this study employed transcutaneous pacing through the thoracic body wall, which typically requires application of greater amounts of electrical energy and increased potential for cardiac and skeletal muscle injury.…”

Potential cardiotoxicity induced by Euodiae Fructus: In vivo and in vitro experiments and untargeted metabolomics research

“…The ECG was foundational in assessing cardiac function in terms of rate and rhythm, and is universally available for the diagnosis of heart diseases (Klabunde, 2017;Teplitzky et al, 2020). Moreover, the determination of cardiac enzyme profiles, including CK, CK-MB, HBDH, LDH, and AST, as evidence of myocardial injury, has been confirmed by substantial research, such as those studies exploring myocardial ischemic necrosis or changes to membrane permeability in myocardial cells (Pappas, 1989;Lee et al, 2009). Despite some promising biomedical approaches in the cardiac research field, cardiac histology is still irreplaceable in the diagnosis of cardiac injuries, owning to the ability of cardiac tissue slices to provide details of the native multicellularity, architecture, and physiology of the heart (Watson et al, 2019;George et al, 2020;Perbellini and Thum, 2020).…”