2001
DOI: 10.1016/s0378-5173(00)00660-8
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Evaluation of chemical stability of St. John's wort commercial extract and some preparations

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Cited by 78 publications
(51 citation statements)
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“…The total yield of the method comprising extraction and both steps of Sephadex column was estimated to be approximately 53%. This could be attributed to loss of naphthodianthrones over Sephadex columns and their fast degradation in solution and under light [4,15,23]. Indeed, when injecting the same pseudohypericin sample to HPLC-DAD, after 4 days a loss of 21% was found (Fig.…”
Section: Resultsmentioning
confidence: 94%
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“…The total yield of the method comprising extraction and both steps of Sephadex column was estimated to be approximately 53%. This could be attributed to loss of naphthodianthrones over Sephadex columns and their fast degradation in solution and under light [4,15,23]. Indeed, when injecting the same pseudohypericin sample to HPLC-DAD, after 4 days a loss of 21% was found (Fig.…”
Section: Resultsmentioning
confidence: 94%
“…John's wort (Hypericum perforatum L.) (SJW) is a widely distributed herbaceous perennial plant, well-known as a medicinal plant since antiquity for a variety of ailments such as diuretics, in neuralgic conditions, in sciatica and in reptile bites [1], in inflammations of the bronchi and urogenital tract, treatment of biliary disorders, bladder irritation, cold, diabetes mellitus, migraine headaches and ulcer [2]. Herbal medicinal products (HMPs) based on hydroalcoholic extracts and standardized, using the naphthodianthrones of the hypericin group, calculated as 0.2 -1 mg of hypericin as a daily dose are prescribed in Europe for the treatment of mild to moderate depressions [3,4], particularly in Germany where it is approximately 20 times more often prescribed than fluoxetine [5]. However, in both Europe and the USA, SJW preparations are also marketed as dietary supplements [4].…”
Section: Introductionmentioning
confidence: 99%
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“…Как отмечается в работах [1,18] нет еди-ного мнения о конкретных компонентах зверобоя, ответственных за то или иное фармакологическое свойство. Предполагается, что эти свойства связа-ны с присутствием нелетучих и малолетучих БАС (гиперицин и его аналоги, гиперфорин и его анало-ги, флавоноиды и другие фенольные соединения) [18][19][20]. Согласно Государственной фармакопее Российской Федерации XIII издания подлинность ЛРС зверобоя определяют методом тонкослой-ной хроматографии путем обнаружения рутина, который широко встречается в растениях, а каче-ство -спектрофотометрическим методом по сумме флавоноидов в пересчете на рутин [21].…”
Section: Introductionunclassified
“…O ICH, americano, e o EMEA (The European Agency for the Evaluation of Medicinal Products), seu correspondente europeu, vêm sendo citados em vários artigos como, por exemplo, os de Bilia et al 3 e de Grimm, 4 como referências em estudo de estabilidade em diversas áreas, obviamente com maior ênfase na farmacêutica, por ser esse seu foco de estudo.…”
Section: Introductionunclassified