Evaluation of Children with Malignancies for Blood and Marrow Transplantation: A Report from the ASTCT Committee on Practice Guidelines

Fraint, Ellen; Abdel‐Azim, Hisham; Bhatt, Neel S.; Broglie, Larisa; Chattha, Asma; Kohorst, Mira A.; Ktena, Yiouli P.; Lee, Michelle A.; Long, Susie; Qayed, Muna; Sharma, Akshay; Stefanski, Heather E.; Vatsayan, Anant; Wray, Lisa; Hamadani, Mehdi; Carpenter, Paul A.

doi:10.1016/j.jtct.2023.02.003

Transplantation and Cellular Therapy

2023

DOI: 10.1016/j.jtct.2023.02.003

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Evaluation of Children with Malignancies for Blood and Marrow Transplantation: A Report from the ASTCT Committee on Practice Guidelines

Ellen Fraint¹,

Hisham Abdel‐Azim²,

Neel S. Bhatt³

et al.

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Cited by 2 publications

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Biomarkers to predict and diagnose pulmonary complications in children post haematopoietic stem cell transplant

Walker,

Haeusler,

Cole

et al. 2024

Clin & Trans Imm

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Objectives. Haematopoietic cell transplant (HCT) is a cellular therapy for a group of high‐risk children with cancer, immunodeficiency and metabolic disorders. Whilst curative for a child's underlying condition, HCT has significant risks associated, including lung injury. These complications are associated with increased post HCT mortality and require improved methods of risk stratification, diagnosis and treatment. Methods. Biomarkers measured in bronchoalveolar fluid and peripheral blood have been identified for both acute and chronic lung injury post HCT.This review evaluates the current research available investigating the use of these biomarkers to improve clinical care, with a focus on the paediatric cohort. Results. Elevated levels of cytokines such as IL‐6, IL‐8, G‐CSF and TNF were identified as potential predictive biomarkers for the development of post HCT lung disease. The pulmonary microbiome was found to have strong potential as a biomarker pre and post HCT for the development of pulmonary complications. General limitations of the studies identified were study design, retrospective or single centre and not exclusively performed in the paediatric population. Conclusion. To translate biomarker discovery into clinical implementation further research is required, utilising larger cohorts of children in prospective trials to validate these biomarkers and determine how they can be translated into better outcomes for children post HCT.

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Biomarkers to predict and diagnose pulmonary complications in children post haematopoietic stem cell transplant

Walker,

Haeusler,

Cole

et al. 2024

Clin & Trans Imm

View full text Add to dashboard Cite

show abstract

Assessing Medicaid Coverage for Hematopoietic Cell Transplantation and Chimeric Antigen Receptor T Cell Therapy: A Project from the American Society for Transplantation and Cellular Therapy and the National Marrow Donor Program ACCESS Initiative

Auletta,

Khera,

DeMartino

et al. 2023

Transplantation and Cellular Therapy

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Evaluation of Children with Malignancies for Blood and Marrow Transplantation: A Report from the ASTCT Committee on Practice Guidelines

Cited by 2 publications

References 103 publications

Biomarkers to predict and diagnose pulmonary complications in children post haematopoietic stem cell transplant

Biomarkers to predict and diagnose pulmonary complications in children post haematopoietic stem cell transplant

Assessing Medicaid Coverage for Hematopoietic Cell Transplantation and Chimeric Antigen Receptor T Cell Therapy: A Project from the American Society for Transplantation and Cellular Therapy and the National Marrow Donor Program ACCESS Initiative

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