Evaluation of chitosan nano dressing for wound healing: Characterization, in vitro and in vivo studies

Archana, D.; Dutta, Joydeep; Dutta, Pradip Kumar

doi:10.1016/j.ijbiomac.2013.03.002

Cited by 416 publications

(213 citation statements)

References 36 publications

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“…Photographs were taken immediately after wounding and on days 6, 9, 12, 15, 18 and 21 post-operation by a digital camera while a ruler was placed near the wounds. The wound areas were analyzed by Measuring Tool of Adobe Acrobat 9 Pro Extended software (Adobe Systems Inc, San Jose, CA, USA) and wound contraction percentage was calculated using the following formula: Percentage of wound contraction=(A 0 -A t )/A 0 ×100 Where A 0 is the original wound area and A t is the wound area at the time of imaging [30]. The animals were left in separate cages for four days at room conditions for acclimatization.…”

Section: Excision Wound Model and Planimetric Studiesmentioning

confidence: 99%

Effects of Aloe Vera and Chitosan Nanoparticle Thin-Film Membranes on Wound Healing in Full Thickness Infected Wounds with Methicillin Resistant Staphylococcus Aureus

Ranjbar

Yousefi

2018

BEAT

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Objective: To assess effect of Aleo vera with chitosan nanoparticle biofilm on wound healing in full thickness infected wounds with antibiotic resistant gram positive bacteria. Method: Thirty rats were randomized into five groups of six rats each. Group I: Animals with uninfected wounds treated with 0.9% saline solution. Group II: Animals with infected wounds treated with saline. Group III: Animals with infected wounds were dressed with chitosan nanoparticle thin-film membranes. Group IV: Animals with infected wounds were treated topically with Aloe vera and Group V: Animals with infected wounds were treated topically with Aloe vera and dressed with chitosan nanoparticle thin-film membranes. Wound size was measured on 6, 9, 12, 15, 18 and 21days after surgery. Results: Microbiology, reduction in wound area and hydroxyproline contents indicated that there was significant difference (p<0.05) between group V and other groups. Quantitative histological studies and mean rank of the qualitative studies demonstrated that there was significant difference (p<0.05) between group V and other groups. Conclusion: The Aloe vera with chitosan nanoparticle thin-film membranes had a reproducible wound healing potential and hereby justified its use in practice.

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Section: Excision Wound Model and Planimetric Studiesmentioning

confidence: 99%

Effects of Aloe Vera and Chitosan Nanoparticle Thin-Film Membranes on Wound Healing in Full Thickness Infected Wounds with Methicillin Resistant Staphylococcus Aureus

Ranjbar

Yousefi

2018

BEAT

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“…In addition, carbon allotrope nanomaterials have been applied successfully to enhance wound healing in at least pilot studies in rodent models, including AgNPloaded graphene hydrogel dressings (Fan et al, 2014), graphene quantum dots that enhance bactericidal effects of hydrogen peroxide ) and a graphene-chitosan nanofiber material that possessed both antibacterial as well as enhanced wound-healing properties with minimal scarring in both mice and rabbits (Lu et al, 2012a). Finally, titanium oxide NPs in combination with chitosan and pectin enhanced antibacterial activity in vitro as well as enhanced wound closure and epithelial regeneration in a mouse model (Archana et al, 2013).…”

Section: Other Nanomaterials For Skin Tissue Regenerationmentioning

confidence: 99%

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

et al. 2016

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Nanomaterials have attracted the interest of tissue engineers for the last two decades. Their unique properties make them promising for de novo fabrication of bio-inspired hybrid/composite materials with improved regenerative properties, including, for example, the capacity for electric conductivity and the provision of antimicrobial properties. However, to this day, the use of such materials in medical applications is rather limited and most of the studies have only reached the archetypical proof-of-concept stage. Herein, we present a review on the use of nanomaterials in tissue engineering for regenerative therapies of heart, skin, eye, skeletal muscle, and nervous system. The advantages and limitations of nano-engineering materials are presented in this review alongside with the future challenges and milestones nanotechnology must overcome to make an impact in biomedical applications.

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“…Chitosan has been used in treating burn injuries in rats and for skin grafting and bone wound repair in dogs [63]. Chitosan can be made into membranes, nanofibers, scaffolds and has excellent swelling, biodegradable and hydrophilic properties [64]. Various types of delivery formats have been made with chitosan and chitosan derivatives, such as chitosan mesh membrane, to study wound healing [65].…”

Section: Chitosan In Wound Healingmentioning

confidence: 99%

Chitosan Nanoparticles for Generating Novel Systems for Better Applications: A Review

G¹,

KS²

2015

J Mol Genet Med

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The environmental sustainability and use of environmentally acceptable biomaterials are major areas of scientific and industrial research. In recent times, identification and application of suitable biopolymers instead of petroleum derived conventional polymers are gaining more attention. Chitosan and chitosan derived nanoparticles and nanocomposites are very promising due to their versatile properties and have found applications in various areas such as biomedical, foods, food packaging and personal care. Many studies suggest that chitosan nanoparticles and their derivatives are one of the best barrier and film coating materials for preserving the quality of foods and for delivering skin care products, mainly due to their biodegradability and anti-microbial properties. The present review gives insight on the progress made in the application of chitosan nanoparticles specifically in foods and food packaging, personal care products and in biomedical industry. Future studies shall address establishment of industrial scale up of chitosan nanoparticles, safety and quality aspects of these chitosan derived products for human use.

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Evaluation of chitosan nano dressing for wound healing: Characterization, in vitro and in vivo studies

Cited by 416 publications

References 36 publications

Effects of Aloe Vera and Chitosan Nanoparticle Thin-Film Membranes on Wound Healing in Full Thickness Infected Wounds with Methicillin Resistant Staphylococcus Aureus

Effects of Aloe Vera and Chitosan Nanoparticle Thin-Film Membranes on Wound Healing in Full Thickness Infected Wounds with Methicillin Resistant Staphylococcus Aureus

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

Chitosan Nanoparticles for Generating Novel Systems for Better Applications: A Review

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