Evaluation of choroidal parameters in eyes at the first onset of acute anterior uveitis

Abstract

Background Little is known about choroidal involvement in anterior uveitis. The aim of our study was to evaluate changes in choroidal thickness and volume in eyes with acute anterior uveitis (AAU) using enhanced depth imaging-optical coherence tomography (EDI-OCT) at baseline and after treatment, which were compared with healthy fellow eyes. Methods For the study, 35 individuals with unilateral acute AAU at the first onset were enrolled. Subfoveal thickness and choroidal volume were measured with EDI-OCT in nine Early Treatment of Diabetic Retinopathy Study (ETDRS) subfields before and after the completion of treatment. Moreover, axial length measurements of both eye bulbs were determined by optical biometry. Results No statistically significant differences in choroidal thickness or choroidal volume were detected between AAU eyes at baseline and after treatment and fellow eyes. Positive correlations between the values of anterior chamber flare and absolute CT changes in both temporal and inferior ETDRS fields, as well as in superior outer ring were detected. Negative correlations between age and both choroidal thickness and choroidal volume were detected in AAU eyes at baseline and after treatment, as well as in fellow eyes. Conclusions Evaluation of the choroid with EDI-OCT does not appear to be a reliable tool for the treatment monitoring of eyes with anterior uveitis.

The state of the choroid in children with anterior uveitis assessed by optical coherence tomography

“…Попытки оценить роль этого параметра при передних увеитах [7][8][9][10][11][12][13][14] дали противоречивые результаты. В ряде работ обнаружено увеличение толщины сосудистой оболочки в субфовеолярной и парафовеолярной зонах в период активности воспаления [8,10,[12][13][14], а H. Yan и соавт.…”

Commentary: Role of choroidal thickness assessment in acute anterior uveitis

“…Although by definition, anterior uveitis (AU) denotes involvement of the anterior segment of the eye, a limited number of studies have also reported changes in the CT in patients with acute anterior uveitis (AAU) suggesting possible choroidal involvement in AU. [ 1 2 3 4 5 6 7 8 9 10 ] Recent advances in spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging (EDI) mode and swept-source OCT (SS-OCT) have led to better imaging of the choroid providing further insight to pathogenesis of such entities.…”

“…Majority of the studies assessing CT in AAU have evaluated unilateral nongranulomatous AAU or selective HLA-B27-associated AAU patients and compared the CT with either healthy fellow eye or a separate group of age-matched healthy control additionally. [ 1 2 3 4 6 7 8 9 ] Few of these studies are retrospective,[ 1 3 7 8 ] while others are prospective;[ 2 4 5 6 9 ] the sample size varied between 16 and 120 patients of AAU across these studies. [ 1 2 3 4 5 6 7 8 9 ] Measurement of the CT in these studies was derived either from single point subfoveal CT or from multiple Early treatment of Diabetic Retinopathy Study (ETDRS) subfields with the help of in-built caliper-based manual measurement or automated integrated software-based segmentation of the sclero-choroidal interface (SCI).…”

“…[ 1 2 3 4 6 7 8 9 ] Few of these studies are retrospective,[ 1 3 7 8 ] while others are prospective;[ 2 4 5 6 9 ] the sample size varied between 16 and 120 patients of AAU across these studies. [ 1 2 3 4 5 6 7 8 9 ] Measurement of the CT in these studies was derived either from single point subfoveal CT or from multiple Early treatment of Diabetic Retinopathy Study (ETDRS) subfields with the help of in-built caliper-based manual measurement or automated integrated software-based segmentation of the sclero-choroidal interface (SCI). [ 1 2 3 4 5 6 7 8 9 ] Most of the authors have reported increased CT in the active inflammatory phase of AAU[ 1 2 3 4 6 7 ] and few of them further demonstrated subsequent decrease in CT with successful treatment.…”

“…[ 1 2 3 4 5 6 7 8 9 ] Measurement of the CT in these studies was derived either from single point subfoveal CT or from multiple Early treatment of Diabetic Retinopathy Study (ETDRS) subfields with the help of in-built caliper-based manual measurement or automated integrated software-based segmentation of the sclero-choroidal interface (SCI). [ 1 2 3 4 5 6 7 8 9 ] Most of the authors have reported increased CT in the active inflammatory phase of AAU[ 1 2 3 4 6 7 ] and few of them further demonstrated subsequent decrease in CT with successful treatment. [ 2 3 4 5 ] The findings in the present study are consistent with the above reports.…”