Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography

Dhoot, Dilsher S.; Huo, Siya; Yuan, Alex; Xu, David; Srivistava, Sunil; Ehlers, Justis P.; Traboulsi, Elias I.; Kaiser, Peter K.

doi:10.1136/bjophthalmol-2012-301917

Cited by 133 publications

(100 citation statements)

References 22 publications

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“…It may be related to the characteristic photoreceptor degeneration of CD, which could cause choroidal thinning. A similar thinning of the choroid has been reported in patients with other inherited retinal dystrophies and in animal models (4,5,10) . Destruction of the RPE cells has been reported in animal models of disease responsible for secondary choriocapillaris atrophy (5,11) .…”

Section: Discussionsupporting

confidence: 48%

“…Destruction of the RPE cells has been reported in animal models of disease responsible for secondary choriocapillaris atrophy (5,11) . A requirement for vascular endothelial growth factor, which is produced by RPE cells, has been demonstrated for choroidal maintenance; therefore, this growth factor may play a role in choroidal thinning (4,12) . The retinas, and especially the photoreceptor cells, are the most metabolically active tissues in the body, and their oxygen consumption is faster than that seen in other tissues (13) .…”

Section: Discussionmentioning

confidence: 99%

“…Images acquired with EDI-OCT not only have an improved ability to visualize the deeper ocular structures and the choroid; they also allow the thickness and contour of the choroid to be assessed (5) . (4,5) . The pathogenesis of photoreceptor cell deterioration and RPE dysfunction in CD remains unclear, and knowledge on the changes in the choroid in retinal dystrophies is limited.…”

Section: Introductionmentioning

confidence: 99%

“…Alterations in the retinal structure were previously demonstrated in patients with CD using spectral-domain optical coherence tomography (SD-OCT) (3) , and some investigators have observed reduced neuroretinal thickness in the fovea centralis and macula using SD-OCT (3) . Enhanced depth imaging (EDI) is a technique that can be utilized to examine both the retina and choroid using specific focusing techniques and an SD-OCT device (4) . Images acquired with EDI-OCT not only have an improved ability to visualize the deeper ocular structures and the choroid; they also allow the thickness and contour of the choroid to be assessed (5) .…”

Section: Introductionmentioning

confidence: 99%

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Is there a relationship between outer retinal destruction and choroidal changes in cone dystrophy?

Ayyıldız¹,

Özge²,

Küçükevcilioğlu³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Approved by the following research ethics committee: GATA Medical School (# 2015-KAEK-45). ABSTRACT Purpose:The aim of the present study was to use enhanced depth imaging optical coherence tomography (EDI-OCT) to investigate choroidal changes in patients with cone dystrophy (CD) and to correlate these findings with clinical and electroretinography (ERG) findings. Methods: This case-control study included 40 eyes of 20 patients with CD and 40 eyes of 40 age-and refraction-matched healthy individuals. Choroidal thickness (CT) measurements were obtained under the foveal center and at 500 and 1,500 µm from the nasal and temporal regions to the center of the fovea, respectively. EDI-OCT and ERG data were analyzed, and the correlations of CT with the best-corrected visual acuity (BCVA) and the central foveal thickness (CFT ) were evaluated. Results: The mean subfoveal CTs in the CD and control groups were 240.70 ± 70.78 and 356.18 ± 48.55 µm, respectively. The subfoveal CT was significantly thinner in patients with CD than in the controls (p<0.001). The patients with CD also had significantly thinner choroids than the controls at each measurement location relative to the fovea (p<0.001). The subfoveal CT in the CD group correlated with CFT (p=0.012), but no significant correlation was found between the subfoveal CT and BCVA or photopic ERG responses. Conclusions:The present study demonstrated a significant thinning of the choroid in patients with CD. EDI-OCT is a useful technique for describing the choroidal changes occurring in CD. Future studies investigating the association between choroidal changes and outer retinal destruction or the disease stage may provide a better understanding of the pathophysiology of CD.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is there a relationship between outer retinal destruction and choroidal changes in cone dystrophy?

Ayyıldız¹,

Özge²,

Küçükevcilioğlu³

et al. 2016

Arquivos Brasileiros De Oftalmologia

View full text Add to dashboard Cite

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“…19 Submacular choroidal thickness (CT) was measured manually from the inner border of the sclera to the outer border of the RPE vertically using the calipers of the Heidelberg reader software. 20 …”

Section: Methodsmentioning

confidence: 99%

Correlation of structure and function of the macula in patients with retinitis pigmentosa

Battu

Khanna

Hegde³

et al. 2015

Eye

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Purpose To correlate the structure of the macula, as measured by spectral-domain optical coherence tomography (SD-OCT) and function, as measured by microperimetry (MAIA) in patients with retinitis pigmentosa (RP) and relatively good visual acuity. Design Prospective, cross-sectional, nonintervention study. Subjects Patients with RP. Methods Thirty patients with RP and good central visual acuity were identified. Each patient underwent SD-OCT of the macula and microperimetry. The images were overlaid using the custom-designed software. The retinal sensitivity by microperimetry was correlated with corresponding retinal thickness, as measured by the SD-OCT. ELM, COST, and IS/OS junction were scored as intact, disrupted, or absent. Main outcome measures Comparing the retinal sensitivity on the MAIA with various measurements on the SD-OCT. Results The retinal sensitivity on the MAIA showed a significant correlation with total retinal thickness and outer retinal thickness on the SD-OCT. There was no association with either the inner retinal thickness or the choroidal thickness. ORT showed a statistically significant correlation with the anatomical classification of ELM (r = − 0.76, Po0.001), IS/OS (r = − 0.800, Po0.001), and COST (r = − 0.733, Po0.001). Conclusion This study determined that there was a high correlation of the structure and function of the central macula in patients with RP. These studies are important to establish surrogate markers that can be used as end points for various tests in future therapeutic clinical trials.

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N‐methyl‐N‐nitrosourea induces retinal degeneration in the rat via the inhibition of NF‐κB activation

Xiong

Song

et al. 2016

Cell Biochemistry & Function

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Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized by the loss of photoreceptor cells through apoptosis. N-methyl-N-nitrosourea (MNU) is an alkylating toxicant that induces photoreceptor cell death resembling hereditary RP. This study aimed to investigate the role of nuclear factor κB (NF-κB) in MNU-induced photoreceptor degeneration. Adult rats received a single intraperitoneal injection of MNU (60 mg/kg bodyweight). Hematoxylin and eosin staining demonstrated progressive outer nuclear layer (ONL) loss after MNU treatment. Transmission electron microscopy revealed nuclear pyknosis, chromatin margination in the photoreceptors, increased secondary lysosomes, and lobulated retinal-pigmented epithelial cells in MNU-treated rats. Numerous photoreceptor cells in the ONL showed positive TUNEL staining and apoptosis rate peaked at 24 hours. Enhanced depth imaging spectral-domain optical coherence tomography showed ONL thinning and decreased choroid thickness. Electroretinograms showed decreased A wave amplitude that predominated in scotopic conditions. Western blot analysis showed that nuclear IκBα level increased, whereas nuclear NF-κB p65 decreased significantly in the retinas of MNU-treated rats. These findings indicate that MNU leads to selective photoreceptor degradation, and this is associated with the inhibition of NF-κB activation.

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Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography

Cited by 133 publications

References 22 publications

Is there a relationship between outer retinal destruction and choroidal changes in cone dystrophy?

Is there a relationship between outer retinal destruction and choroidal changes in cone dystrophy?

Correlation of structure and function of the macula in patients with retinitis pigmentosa

N‐methyl‐N‐nitrosourea induces retinal degeneration in the rat via the inhibition of NF‐κB activation

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