Evaluation of chronic inflammation in the aetiology of venous insufficiency by investigating cytomegalovirus DNA

Beyaz, Metin Onur; Bozkurt, Emre; Önalan, Mehmet Akif; Öztaş, Didem Melis; Meriç, Murat; Ulukan, Mustafa Özer; Coşkun, Uğur; Uğurlucan, Murat

doi:10.5114/aoms.2019.85232

Cited by 3 publications

(4 citation statements)

References 13 publications

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“…It is known that chronic venous insufficiency affects social life and may cause serious socio-economic loss (16). Clinically, the patients suffer from swollen legs, general edema, repeating phlebitis attacks and ulcers (6). Pain was present in all of our patients; it is the most common symptom.…”

Section: Discussionmentioning

confidence: 63%

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Thermal Ablation, Nonthermal Ablation And Surgical Striping Applications: 1-Year Single Center Early Results

Beyaz

Urfalı

Koyuncu

et al. 2022

mkutfd

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ABSTRACT: Objectives : Starting from the 1900's minimally invasive methods such as endovenous laser ablation (EVLA), radiofrequency ablation (RFA), and ultrasound-guided foam sclerotherapy (UGFS) developed. Methods: This study includes a total of 136 patients (81 women/55 men), of whom 22 (10 women/12 men) were treated with classic surgical stripping, 54 (32 women/22 men) with thermal ablation and 60 (39 women/55 men) with non-thermal ablation. Results: Twenty-two patients (10 women/12 men) were treated with surgical stripping. In one female patient a hematoma arose in the medial crural region postoperatively. A radiofrequency catheter (ThermoBLOCK TM) was used in the thermal ablation procedures in 54 patients (32 female/22 male). It is believed that permanent paresthesia occured in one female patient after the procedure. In 3 male patients temporary paresthesia occured postoperatively. Non- thermal ablation was performed in 60 patients(39 female/55 male). Even through a severe burning sensation was present in 6 patients (5 female/1 male) during the procedure, this symptom was only transient. In one of the patients, deep venous thrombosis (DVT) occured at the level of the popliteal vein postoperatively at the sixth day. Conclusion: Even if thermal and non-thermal ablation and surgical procedures have the same pain decreasing rates, hematomas and a longer hospital stay are more frequent in surgical procedures.

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Section: Discussionmentioning

confidence: 63%

“…Pain is the most common symptom in patients with chronic venous insufficiency, but in some untreated patient groups, chronic venous insufficiency causes ulcers that are triggered by chronic inflammation and are difficult to treat (6).…”

Section: Introductionmentioning

confidence: 99%

Thermal Ablation, Nonthermal Ablation And Surgical Striping Applications: 1-Year Single Center Early Results

Beyaz

Urfalı

Koyuncu

et al. 2022

mkutfd

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“…6 Also, in the literature, there are some studies that have shown infectious agents such as cytomegalovirus, chlamidia pneumonia, Helicobacter pylori, and some herpesvirus subtypes may be responsible in the triggering of vascular infl ammatory cascade. 16 CRP and serum albumin are two of the infl ammation markers and widely used in clinical practice. While CRP is lack of immediate postoperative and postoperative long--term blood samples and correlation analysis; however, early postoperative period is an infl ammatory state and blood samples drawn at that period would not reveal reliable correlation analysis.…”

Section: Discussionmentioning

confidence: 99%

Increased CRP/albumin ratio is associated with superficial venous reflux disease and varicose vein formation

Ünal¹,

Öztaş²,

Beyaz³

et al. 2021

Cor Vasa

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Nedávno byl publikován názor, že kromě zvýšeného žilního tlaku může vznik a progresi křečových žil ovlivňovat i zánět. Poměr C-reaktivního proteinu (CRP) a albuminu (CRP/albumin ratio, CAR) představuje nový marker zánětu spojený s nepříznivou prognózou u různých skupin pacientů. Cílem naší studie bylo zjistit vztah mezi průměrem varikózní velké safény (varicose greater saphenous vein, VSM) a parametrem CAR. Metody: Do studie bylo zařazeno celkem 150 pacientů s nedostatečností VSM (skupina 1, n = 114) a nepostiženými VSM (n = 36). Průměr VSM se měřil B-mode ultrazvukem a refl ux se kvantifi koval délkou uzavírání chlopně měřenou spektrální dopplerovskou křivkou. Krevní vzorky se odebíraly při zařazování pacientů do studie. Hodnota CAR se stanovuje vydělením hodnoty CRP hodnotou albuminu v séru. Výsledky: Skupinu 1 tvořilo 21 (18,4 %) mužů a 93 (81,5 %) žen; ve skupině 2 bylo 7 mužů a 29 žen. Průměrný věk pacientů v obou skupinách byl podobný (48,02 ± 12,20 roku ve skupině 1 vs. 44,9 ± 8,92 roku ve skupině 2; p = 0,44). Průměrná hodnota indexu tělesné hmotnosti (BMI) pacientů se významně nelišila (skupina 1: 26,4 ± 3,7 kg/m 2 vs. skupina 2: 25,7 ± 4,2 kg/m 2 ; p = 0,13). Průměrné hodnoty průměru VSM byly 5,70 ± 0,29 mm ve skupině 1 a 3,21 ± 0,34 mm ve skupině 2 (p = 0,0023). Průměrné hodnoty CRP a albuminu ve skupině 1 byly 6,18 ± 4,99 mg/l, resp. 4,45 ± 0,27 g/dl; ve skupině 2 to bylo 4,25 ± 2,46 mg/l, resp. 6,18 ± 1,14 g/dl (hodnota p pro CRP = 0,049, hodnota p pro albumin = 0,074). Poměr CRP/albumin ve skupině 1 činil 1,28 ± 1,34; ve skupině 2 byla naměřena hodnota 1,11 ± 1,21, tedy statisticky nevýznamný rozdíl (p = 0,58). Byla nalezena středně těsná korelace mezi průměrem VSM a poměrem CRP/albumin i refl uxem povrchových žil (r: 0,48). Závěr: Zvýšený poměr CRP/albumin je spojen se zvýšenou incidencí varixů a větším průměrem velké safény, a tedy i vyšší incidencí refl uxu povrchových žil. Zjištění podporují hypotézu, že ve vzniku křečových žil může hrát jistou úlohu systémový zánět.

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“…Lower limb varicose veins (VVs) are the most common vascular condition and may cause hyperpigmentation, eczema, and active ulcers, resulting in a significant decrease in quality of life (QoL) [1]. The therapeutic procedures for VVs include conventional surgery, endovenous thermal ablation, foam sclerotherapy, and mechanochemical ablation, whereas endovenous laser ablation (EVLA) and radiofrequency ablation (RFA) are the most widely used and guideline-recommended procedures (IB recommendations) [2][3][4][5][6][7][8][9][10]. EVLA and RFA procedures typically involve thermal ablation of the great saphenous vein (GSV) above the knee or foam sclerotherapy and pin stripping for VVs below the knee.…”

Section: Introductionmentioning

confidence: 99%

Hybrid endovenous laser ablation reduces the recurrence of varicose veins below the knee compared with radiofrequency ablation: A real-world study

et al. 2023

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IntroductionThis study aimed to investigate the outcome of hybrid endovenous laser ablation (EVLA, 1470 nm) and radiofrequency ablation (RFA) procedures for varicose veins (VVs).Material and methodsWe retrospectively analyzed the clinical data of patients from July 2019 to December 2020. Eighty-four patients (121 limbs) underwent hybrid EVLA procedure, and 108 patients (151 limbs) underwent RFA procedure. The outcomes, venous clinical severity score (VCSS), chronic venous disease quality-of-life questionnaire (CIVIQ-20) score and recurrence at 1, 6, and 12 months were collected.ResultsNo differences in complications or 24-h pain scores were noted between the two procedures, but a lower dosage of foam sclerosant was used in EVLA procedure than in RFA procedure (P<0.02). The postoperative VCSS and CIVIQ-20 scores in two groups were significantly decreased compared with the scores before the procedure, and no differences in scores were noted between the two procedures at 1 month. However, the VCSS and CIVIQ-20 scores for EVLA procedure were significantly better than those for RFA procedure at 6 and 12 months (P<0.05). Both procedures showed a similar great saphenous vein closure rate at 12 months. The EVLA procedure showed lower rates of overall recurrence (4.96% vs. 14.57%, OR: 3.27, 95% CI: 1.33-8.00, P=0.01) and recurrence below the knee (4.13% vs. 11.92%, OR: 3.14; 95% CI: 1.18-8.35, P=0.02). Moreover, the patient satisfaction score was greater for EVLA procedure than RFA procedure (P<0.02).ConclusionsThe hybrid EVLA (1470 nm) procedure reduces VV recurrence below the knee and results in better quality-of-life scores.

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Evaluation of chronic inflammation in the aetiology of venous insufficiency by investigating cytomegalovirus DNA

Cited by 3 publications

References 13 publications

Thermal Ablation, Nonthermal Ablation And Surgical Striping Applications: 1-Year Single Center Early Results

Thermal Ablation, Nonthermal Ablation And Surgical Striping Applications: 1-Year Single Center Early Results

Increased CRP/albumin ratio is associated with superficial venous reflux disease and varicose vein formation

Hybrid endovenous laser ablation reduces the recurrence of varicose veins below the knee compared with radiofrequency ablation: A real-world study

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