Evaluation of clinical and pathological characteristics of 155 canines with mammary tumours: a retrospective study

Sontas, BH; Özyoğurtçu, Hande; Gürel, Aydın; Ekici, Hayri

doi:10.4067/s0301-732x2009000100007

Cited by 20 publications

(27 citation statements)

References 22 publications

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“…One clinical study on dogs treated with medroxyprogesterone acetate for oestrus prevention reported a greater risk of developing mammary tumours, the majority being malignant. (16) In our study as well as in other studies (17,18) dogs were admitted in the clinic for examination and treatment, roughly a year after the fi rst detection of the mass. In our study 6 patients (66%) were with multiple mammary tumours.…”

Section: Discussionmentioning

confidence: 71%

Canine Mammary Tumours - Clinical Survey

Petrov

Ilievska

Trojačanec

et al. 2014

Macedonian Veterinary Review

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Original Scientific Article INTRODUCTIONThe mammary gland is a compound tubuloalveolar gland, divided into lobules by interlobular connective tissue. The mammary gland consists of parenchyma (alveoli), stroma (connective tissue), ducts, vessels and nerves. Bitches usually have fi ve pairs of glands. The cranial two pairs are referred to as cranial and caudal thoracic mammary Mammary tumours are the second most frequent neoplasia in dogs, mainly affecting older female patients. Approximately 50% of the mammary tumours are malignant with high percentage of mortality, if not treated in time. The aim of this study was to analyze the data of canine patients with mammary tumours, to evaluate the type of tumours, as well as the relationship between tumour incidence and dogs' age, reproductive cycle and sterilization. The survey was used to retrieve the information in the period of two years from the patient data base of the University Veterinary Hospital at the Faculty of veterinary medicine in Skopje. Patients included in this survey were subjected to routine clinical investigation and additional laboratory tests (cytological examination, x-rays imaging, CBC and biochemical profile, histopathology of the tumor samples). Aged female patients (12 -13 years) are the most susceptible category for development of mammary tumours. The reproductive history showed that five of the patients with malignant mammary tumours have never whelped and were not treated with any exogenous hormones. Malignant tumours (adenocarcinoma) were diagnosed in 90% of the patients. Three patients died due to lung metastasis. Late diagnosis is one of the major problems that results in lethal outcome due to lung metastases. Since ovarian steroids play an important role in the aetiology, the most effective prevention of mammary tumours is elective ovariectomy of the bitch at an early age.

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Section: Discussionmentioning

confidence: 71%

Canine Mammary Tumours - Clinical Survey

Petrov

Ilievska

Trojačanec

et al. 2014

Macedonian Veterinary Review

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“…The histological tumor type is an important factor for the survival of affected animals (Sontas et al, 2009). Mammary carcinomas in dogs have similarities with breast cancer in humans, including the high prevalence of adenocarcinoma, frequency of metastasis and progressive disease (Sartin et al, 1992).…”

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confidence: 99%

Detection of mutations within exons 4 to 8 of the p53 tumor suppressor gene in canine mammary glands

Souza¹,

Barros²,

Silva³

et al. 2012

Arq. Bras. Med. Vet. Zootec.

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Fifteen female canines with mammary tumors and 6 normal females were used to study mutations in exons 4 to 8 of the p53 gene. DNA samples from the tumors, respective adjacent normal mammary tissue and mammary glands from healthy animals were sequenced and analyzed for the presence of mutations. Mutations were found in 71.8% of the samples and the most frequent were missense mutations. The most attacked exons in the mammary tumor were 5, 7 and 8, with 23.4, 31.6 and 23.4% mutations, respectively. Canine mammary tumors are related to mutations in gene p53 and mutations mostly occur in the region of the protein that is linked to the DNA in the cell nucleus, which can change the functionality of the cell and propitiate tumor growth. Despite being macroscopically normal, the mammary tissue adjacent to the tumors has mutations that can lead to recurrence if not removed together with the tumor.

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“…No entanto, o valor por eles encontrado para animais de pequeno porte, divergiu do estudo, que obteve resultado superior e apresentouse de acordo com Sontas et al (2009), os quais afirmam que tumores mamários malignos ocorrem comumente em fêmeas de pequeno porte, acometendo principalmente as glândulas mamárias inguinais, como ocorreu, neste estudo, em 61,53% dos casos avaliados de estádio IV e V. Ainda em relação às fêmeas de pequeno porte, observou-se, neste estudo, que 53,33% delas desenvolveram tumores menores que 3 cm, sendo que 75% eram de natureza invasiva, classificados em estádio IV, ao Ribas et al (2012) Archives of Veterinary Science, v.17, n.1, p.60-68, 2012.…”

Section: Methodsunclassified

Alterações Clínicas, Epidemiológicas, Citológicas, Histológicas e Estadiamento de Cães com Neoplasias Mamárias

Ribas¹,

Dornbusch²,

Faria

et al. 2012

AVS

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RESUMO:As neoplasias de glândulas mamárias são comumente encontradas na rotina da clínica cirúrgica de pequenos animais, sendo superadas em número de casos apenas por neoplasias de pele. As neoplasias mamárias acometem principalmente cadelas não castradas ou castradas após vários cios, na faixa etária geriátrica, sem qualquer predisposição racial. Etiologicamente desenvolve-se a partir da produção de estrógeno e progesterona em progressão geométrica a cada ciclo estral apresentado durante a vida da cadela. O objetivo deste estudo foi analisar as alterações clínicas relevantes em 36 cadelas com neoplasias mamárias estadiadas. Neste estudo, observou-se que 88,88% das cadelas avaliadas não eram castradas e que a média de idade total foi equivalente à 9,9 anos, independentemente do porte do animal. O maior acometimento envolveu cadelas obesas, sem raça definida, as quais compreendem o maior número de animais atendidos na unidade hospitalar estudada. Foi encontrado um maior número de adenocarcinomas em pacientes com estadiamento de grau IV. Conclui-se que a incidência de neoplasias mamárias, neste estudo, foi equivalente a 51%, de todos os pacientes portadores de neoplasias atendidos no Serviço de Oncologia, com 89% dos animais acometidos acima do peso desejado e estando o adenocarcinoma presente em quase metade das massas tumorais avaliadas. Palavras-chave: alterações clínicas; neoplasias mamárias; cadelas RELEVANT CLINICAL ALTERATIONS IN FEMALE DOGS WITH MAMMARY NEOPLASIAS STAGEDABSTRACT: The mammary gland neoplasias are commonly found in surgical clinic routine of small animals, being overcome in number of cases just for skin neoplasias. The mammary neoplasias bases mainly on the attack of female dogs no castrated or castrated after several ruts, in the geriatric age group, without any racial predisposition. Etiologically develops from the production of estrogen and progesterone in geometric progression with each estrous cycle presented during the life of the dog. The objective of this study was to analyze relevant clinical alterations in 36 female dogs with mammary neoplasias staged. In this study, it was observed that 88,88% of the appraised female dogs were not castrated and that the average of total age was equivalent to 9,9 years, without difference between load and age, attacking obese animals, and with larger attack of female dogs without defined race, which understand the largest number of animals assisted in the Hospitalar Unit studied. It was found a larger adenocarcinomas number in patients with estadiamento of IV degree. It is ended that the incidence of mammary neoplasias, in this study, was equivalent to 51%, of all the patients neoplasias bearers assisted in the Service of Oncologia, with 89% of the animals attacked above the wanted weight and being the present adenocarcinoma in almost half of the masses appraised tumorais.

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Evaluation of clinical and pathological characteristics of 155 canines with mammary tumours: a retrospective study

Cited by 20 publications

References 22 publications

Canine Mammary Tumours - Clinical Survey

Canine Mammary Tumours - Clinical Survey

Detection of mutations within exons 4 to 8 of the p53 tumor suppressor gene in canine mammary glands

Alterações Clínicas, Epidemiológicas, Citológicas, Histológicas e Estadiamento de Cães com Neoplasias Mamárias

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