Evaluation of Clinical Parameters and Levels of Proinflammatory Cytokines in the Crevicular Fluid Around Dental Implants in Patients with Type 2 Diabetes Mellitus

Doğan, Şeyma Bozkurt; KURTİŞ, Mazlum Bülent; Tüter, Gülay; Serdar, Muhittin; Watanabe, Keiko; Каракис, С. Г.

doi:10.11607/jomi.3787

Cited by 21 publications

(23 citation statements)

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“…After full text reading, the 10 studies were excluded due to following reasons: 1) focus on the comparison of PICF interleukin-1 beta (IL-1β) and plasma tumor necrosis factor-alpha (TNF-α) levels between systemically healthy and diabetic subjects [10], 2) directly compare the biomarkers and enzymes of PICF around implants with gingival crevicular fluid (GCF) around natural teeth [11-15], 3) cytokine evaluation with polymerase chain reaction instead of biomarker levels [16-18], 4) sample composed of only failing implants instead of peri-implant diseases [19]. …”

Section: Resultsmentioning

confidence: 99%

Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review

Dursun

Tözüm

2016

JOMR

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ObjectivesTo review the current understanding of the biomarkers and enzymes associated with different forms peri-implant diseases and how their level changes influence the pathogenesis of the inflammatory diseases around dental implants.Material and MethodsAn electronic search in two different databases was performed including MEDLINE (PubMed) and EMBASE between 1996 to 2016. Human studies analyse peri-implant crevicular fluid (PICF) biomarker and enzyme levels of implants having peri-implant mucositis and peri-implantitis published in English language, were evaluated. A systematic review was performed to assess which biomarkers and enzymes in PICF were used to identify the inflammatory conditions around dental implants.ResultsFifty-one articles were identified of which 41 were further evaluated and included in the analysis. Due to significant heterogeneity between included studies, a meta-analysis could not be performed. Instead, a systematic descriptive review was performed.ConclusionsBiomarkers and enzymes in peri-implant crevicular fluid have shown promising results in differentiating from peri-implant disease condition to health. However, due to inconsistent results and acquiring much evidence from cross-sectional studies, additional evidence supported by randomized-controlled trials is needed to validate the links reported.

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Section: Resultsmentioning

confidence: 99%

Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review

Dursun

Tözüm

2016

JOMR

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“…The role of hyperglycemia in the pathogenesis of peri‐implant diseases has been described by several authors . Animal studies have shown that hyperglycemia has negative effects not only on bone formation but also on bone strength osseointegration and fracture healing .…”

Section: Discussionmentioning

confidence: 99%

“…The role of hyperglycemia in the pathogenesis of peri-implant diseases has been described by several authors. [25][26][27][28][29] Animal studies have shown that hyperglycemia has negative effects not only on bone formation but also on bone strength osseointegration and fracture healing. [30][31][32][33] It has been reported that diabetes (regardless of the degree of glycemic control) represents a contraindication for implant treatment.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of biologic implant success parameters in type 2 diabetic glycemic control patients versus healthy patients: A meta‐analysis

Lagunov

Sun

George

2019

J of Invest & Clin Dent

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Aim The aim of the present systematic literature review was to evaluate bleeding on probing (BOP), pocket depth (PD), and marginal bone loss (MBL) in type 2 diabetes mellitus (T2DM) control patients. Methods An electronic literature search was conducted through PubMed, Web of Science, Cochrane, Embase, and ScienceDirect. The search included prospective human clinical studies that analyzed the success of dental implants in T2DM control patients. For inclusion, studies should have had a minimum of 1‐year follow up and should have assessed the following parameters: MBL, BOP and PD. Prior to meta‐analysis, all of the studies were assessed for quality, bias, and heterogeneity. Results Risk of bias analysis indicated that all studies were of moderate quality. After a full‐text evaluation, only seven studies met the inclusion criteria for this meta‐analysis, with a combined total of 443 patients and 530 dental implants. The meta‐analysis indicated a statistically significant difference between parameters of implants placed in the glycemic‐controlled group and healthy group in MBL (P < .001), BOP (P < .04), and PD (P < .001). Conclusion The results of the present study indicated that, despite being glycemic controlled, patients with T2DM were associated with a higher risk of peri‐implant disease.

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“…Once AGEs interact with their specific receptors, proinflammatory cytokines such as interleukin (IL)‐1β and tumor‐necrosis‐factor‐α (TNF‐α) are produced that accumulate in the blood and gingival crevicular fluid (GCF) . These proinflammatory cytokines worsen periodontal inflammation, which may lead to alveolar bone loss around dentition and implants . Long‐term follow‐up studies assessing the survival of adjacent dental implants (ADI) in prediabetic subjects are not yet reported.…”

Section: Introductionmentioning

confidence: 99%

“…[14][15][16][17] These proinflammatory cytokines worsen periodontal inflammation, which may lead to alveolar bone loss around dentition and implants. 18,19 Long-term follow-up studies assessing the survival of adjacent dental implants (ADI) in prediabetic subjects are not yet reported. We therefore hypothesize that inflammatory parameters (depth of probing [PD], plaque index [PI], and bleedingon-probing [BOP]) and mesial and distal CBL are higher around ADI placed in prediabetic subjects as compared to systemically healthy individuals (controls).…”

Section: Introductionmentioning

confidence: 99%

Survival of adjacent‐dental‐implants in prediabetic and systemically healthy subjects at 5‐years follow‐up

Alrabiah

Alrahlah

Al-Hamdan

et al. 2019

Clin Implant Dent Rel Res

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Background Long‐term survival of adjacent dental implants (ADI) in prediabetic patients remained uninvestigated. Purpose This 5 years' follow‐up clinical study compared the survival of adjacent implants in prediabetic and nondiabetic subjects. Materials and Methods Prediabetic (group‐A) and nondiabetic (group‐B) subjects having undergone dental rehabilitation using ADI were assessed. Data about sex, age treatment and period (in years) since diagnosis of prediabetes, and family history of diabetes was gathered and haemoglobin A1c (HbA1c) levels were recorded. Dental implant related data (dimensions, loading protocol, surface characteristics, restoration type, and duration in function) was recorded. Depth of probing (PD), bleeding‐on‐probing (BOP), and plaque index (PI) were measured and mesial and distal crestal bone loss (CBL) were recorded. P values less than .05 were contemplated as statistically‐significant. Results Seventy‐nine male individuals (39 in group‐A and 40 in group‐B) were included. Subjects in groups ‐A and ‐B were 54.3 ± 3.6 and 51.2 ± 2.4 years old, respectively. In group‐A, subjects were diagnosed with prediabetes 5.4 ± 0.2 years ago. Patients in group‐A more often had a family history of diabetes than group‐B. Thirty‐nine and 40 ADI were placed in patients in groups ‐A and ‐B, respectively. Tooth‐brushing once daily was reported by 79.5% and 82.5% individuals in groups ‐A and ‐B, respectively. Peri‐implant PI (P<.001), BOP (P<.001), PD (P<.001), mesial (P<.001), and distal (P<.001) CBL and HbA1c levels (P<.001) were higher in group‐A than group‐B. The implant survival rate in group‐A and group‐B was 100% and 100%, respectively. Conclusion Although ADI can survive in prediabetic patients in the long‐term; soft‐tissue inflammation and CBL are worse around adjacent implants in these patients compared with nondiabetic controls.

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Evaluation of Clinical Parameters and Levels of Proinflammatory Cytokines in the Crevicular Fluid Around Dental Implants in Patients with Type 2 Diabetes Mellitus

Abstract: The results suggest that dental implant therapy can be offered to patients with well-controlled T2DM, as there were no significant differences between control and diabetic patients in terms of clinical parameters or GCF and PICF cytokine levels.

Cited by 21 publications

References 0 publications

Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review

Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review

Evaluation of biologic implant success parameters in type 2 diabetic glycemic control patients versus healthy patients: A meta‐analysis

Survival of adjacent‐dental‐implants in prediabetic and systemically healthy subjects at 5‐years follow‐up

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